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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00017444-protein ID=TCONS_00017444-protein|Name=TCONS_00017444-protein|organism=Clytia hemisphaerica|type=polypeptide|length=721bp
MFKFFHNSNSSSSSSVQNSTAGGGGDSNNSNMGSLRQLEQALLQKDNEIK
KRDSRIAILEQELKKKDETIRNLNRELDKYRSVLNPGQKDGAVAASKTRQ
RMQGISAEPQSLSKTQALAAAPLKRHSKSSKAKEVIRAAIKDNDFLKNLE
SQQVSELVEVMYQKEFKKGEYIIREGEPGSHLYVIEDGQCEVTKDGKQLG
TMGAKKAFGELAILYNCTRTATVRATSTGKLWSIDRQNFQTIMMNTGIKR
QQEHMDFLLSVPVLKDIPEDSLSKIADVLEETFYEEGEYIIRQGARGDTF
FILKKGTVDVTQRASVHSDPQFVRSLGKGAYFGEKALLGEDLRTANVIAG
KGGCTCLVVDREGFSMFIESDIKKDDDKYSDQPKKLSTGPKSPTAIAKEA
DEFADVKLTDLNVIATLGVGGFGRVELVQFSKDNKRTFALKQLKKKHIVE
TRQQDHIMSEKKIMYESHCQFIVRLYKTFKDRKYLYMLLEVCLGGELWTI
LRDRGSFDDNTTRFNVACVIEAFSYLHSKGIVYRDLKPENLLLDEKGYCK
LVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDFAADYWSLGILMY
ELLTGSPPFSGSDPMKTYNIILKGIDMIEFPRKITRNAHNLIKKLCKDNP
SERLGYQKNGLKDIQKHKWFDGFNWDGLRNRKLQPPIIPKIKSNTDASNF
DDYPKDDEIPPDDHTGWDKDF Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0005524 | ATP binding |
| GO:0004692 | cGMP-dependent protein kinase activity |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0004672 | protein kinase activity |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0006468 | protein phosphorylation |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0006468 |
protein phosphorylation |
| molecular_function |
GO:0005524 |
ATP binding |
| molecular_function |
GO:0004692 |
cGMP-dependent protein kinase activity |
| molecular_function |
GO:0004672 |
protein kinase activity |
| molecular_function |
GO:0004674 |
protein serine/threonine kinase activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| None | No IPR available | COILS | Coil | Coil | coord: 35..83 |
| None | No IPR available | GENE3D | 3.30.200.20 | | coord: 373..482
e-value: 4.7E-17
score: 61.5 |
| None | No IPR available | GENE3D | 1.10.510.10 | | coord: 483..690
e-value: 1.8E-61
score: 206.2 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1..37 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 686..721 |
| None | No IPR available | CDD | cd12086 | DD_cGKI-beta | coord: 35..86
e-value: 8.27953E-16
score: 71.9896 |
| None | No IPR available | CDD | cd00038 | CAP_ED | coord: 145..252
e-value: 8.70349E-29
score: 110.879 |
| None | No IPR available | CDD | cd00038 | CAP_ED | coord: 263..371
e-value: 1.06055E-24
score: 99.3225 |
| IPR002374 | cGMP-dependent kinase | PRINTS | PR00104 | CGMPKINASE | coord: 354..363
score: 56.36
coord: 340..349
score: 79.09
coord: 322..329
score: 68.18
coord: 304..313
score: 50.91
coord: 269..283
score: 72.12 |
| IPR002374 | cGMP-dependent kinase | PIRSF | PIRSF000559 | cGMP-dep_kinase | coord: 13..721
e-value: 0.0
score: 1094.4 |
| IPR000961 | AGC-kinase, C-terminal | SMART | SM00133 | pkinase_C_6 | coord: 671..721
e-value: 1.2E-13
score: 61.3 |
| IPR000961 | AGC-kinase, C-terminal | PROSITE | PS51285 | AGC_KINASE_CTER | coord: 671..721
score: 13.485 |
| IPR000719 | Protein kinase domain | SMART | SM00220 | serkin_6 | coord: 411..670
e-value: 2.4E-86
score: 302.8 |
| IPR000719 | Protein kinase domain | PFAM | PF00069 | Pkinase | coord: 413..670
e-value: 3.1E-69
score: 233.2 |
| IPR000719 | Protein kinase domain | PROSITE | PS50011 | PROTEIN_KINASE_DOM | coord: 411..670
score: 46.506 |
| IPR000595 | Cyclic nucleotide-binding domain | SMART | SM00100 | cnmp_10 | coord: 145..258
e-value: 3.8E-26
score: 102.8
coord: 263..386
e-value: 1.6E-21
score: 87.5 |
| IPR000595 | Cyclic nucleotide-binding domain | PFAM | PF00027 | cNMP_binding | coord: 164..245
e-value: 4.4E-21
score: 74.6
coord: 283..370
e-value: 2.4E-17
score: 62.6 |
| IPR000595 | Cyclic nucleotide-binding domain | PROSITE | PS50042 | CNMP_BINDING_3 | coord: 263..385
score: 31.089 |
| IPR000595 | Cyclic nucleotide-binding domain | PROSITE | PS50042 | CNMP_BINDING_3 | coord: 145..260
score: 36.54 |
| IPR014710 | RmlC-like jelly roll fold | GENE3D | 2.60.120.10 | | coord: 248..372
e-value: 1.6E-27
score: 95.5 |
| IPR014710 | RmlC-like jelly roll fold | GENE3D | 2.60.120.10 | | coord: 100..247
e-value: 1.2E-36
score: 125.3 |
| IPR018488 | Cyclic nucleotide-binding, conserved site | PROSITE | PS00889 | CNMP_BINDING_2 | coord: 332..349 |
| IPR018488 | Cyclic nucleotide-binding, conserved site | PROSITE | PS00888 | CNMP_BINDING_1 | coord: 290..306 |
| IPR018488 | Cyclic nucleotide-binding, conserved site | PROSITE | PS00888 | CNMP_BINDING_1 | coord: 172..188 |
| IPR018488 | Cyclic nucleotide-binding, conserved site | PROSITE | PS00889 | CNMP_BINDING_2 | coord: 208..225 |
| IPR008271 | Serine/threonine-protein kinase, active site | PROSITE | PS00108 | PROTEIN_KINASE_ST | coord: 531..543 |
| IPR017441 | Protein kinase, ATP binding site | PROSITE | PS00107 | PROTEIN_KINASE_ATP | coord: 417..441 |
| IPR035014 | cGMP-dependent protein kinase, catalytic domain | CDD | cd05572 | STKc_cGK | coord: 417..677
e-value: 1.82991E-178
score: 512.156 |
| IPR018490 | Cyclic nucleotide-binding-like | SUPERFAMILY | 51206 | cAMP-binding domain-like | coord: 252..370 |
| IPR018490 | Cyclic nucleotide-binding-like | SUPERFAMILY | 51206 | cAMP-binding domain-like | coord: 125..245 |
| IPR011009 | Protein kinase-like domain | SUPERFAMILY | 56112 | Protein kinase-like (PK-like) | coord: 405..709 |
Blast
BLAST of TCONS_00017444-protein vs. Swiss-Prot (Human)
Match: KGP1 (cGMP-dependent protein kinase 1 OS=Homo sapiens GN=PRKG1 PE=1 SV=3) HSP 1 Score: 867.455 bits (2240), Expect = 0.000e+0 Identity = 429/672 (63.84%), Postives = 516/672 (76.79%), Query Frame = 0
Query: 52 RDSRIAILEQELKKKDETIRNLNRELDKYRSVLN-PGQKDGAVAASKTRQRMQGISAEPQSLSKTQALAAAPLKRHSKSSKAKEVIRAAIKDNDFLKNLESQQVSELVEVMYQKEFKKGEYIIREGEPGSHLYVIEDGQCEVTKDGKQLGTMGAKKAFGELAILYNCTRTATVRATSTGKLWSIDRQNFQTIMMNTGIKRQQEHMDFLLSVPVLKDIPEDSLSKIADVLEETFYEEGEYIIRQGARGDTFFILKKGTVDVTQRASVHSDPQFVRSLGKGAYFGEKALLGEDLRTANVIAGKGGCTCLVVDREGFSMFIESDIKKDDDKYSDQPKKLSTGPKSPTAIAKEADEFADVKLTDLNVIATLGVGGFGRVELVQFSKDNKRTFALKQLKKKHIVETRQQDHIMSEKKIMYESHCQFIVRLYKTFKDRKYLYMLLEVCLGGELWTILRDRGSFDDNTTRFNVACVIEAFSYLHSKGIVYRDLKPENLLLDEKGYCKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDFAADYWSLGILMYELLTGSPPFSGSDPMKTYNIILKGIDMIEFPRKITRNAHNLIKKLCKDNPSERLGYQKNGLKDIQKHKWFDGFNWDGLRNRKLQPPIIPKIKSNTDASNFDDYPKD-DEIPPDDHTGWDKDF 721
++ RI LE+ L +K+E I+ L R+L K +SVL P G R QGISAEPQ+ L A ++ +KS ++K++I+ AI DNDF+KNLE Q+ E+V+ MY E+ K II+EG+ GS +YV+EDG+ EVTK+G +L TMG K FGELAILYNCTRTATV+ KLW+IDRQ FQTIMM TG+ + E+M+FL SVP + +PE+ LSK+ADVLEET YE GEYIIRQGARGDTFFI+ KGTV+VT+ S DP F+R+LGKG +FGEKAL GED+RTANVIA + TCLV+DR+ F I + Y D ++ EA FA++KL+D N+I TLGVGGFGRVELVQ + +TFA+K LKK+HIV+TRQQ+HI SEK+IM +H FIVRLY+TFKD KYLYML+E CLGGELWTILRDRGSF+D+TTRF ACV+EAF+YLHSKGI+YRDLKPENL+LD +GY KLVDFGFAKKIGFG+KTWTFCGTPEYVAPEIILNKGHD +ADYWSLGILMYELLTGSPPFSG DPMKTYNIIL+GIDMIEFP+KI +NA NLIKKLC+DNPSERLG KNG+KDIQKHKWF+GFNW+GLR L PPIIP + S TD SNFD +P+D DE PPDD++GWD DF
Sbjct: 15 KEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTT-----RAQGISAEPQTYRSFHDLRQA-FRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSFKHLIGGLDDVSNKAYEDA--------EAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671
The following BLAST results are available for this feature:
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