Putative secreted metalloproteinase (polypeptide) - C. hemisphaerica

Overview
NamePutative secreted metalloproteinase
Unique NameTCONS_00071436-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length377

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00071436-protein ID=TCONS_00071436-protein|Name=Putative secreted metalloproteinase|organism=Clytia hemisphaerica|type=polypeptide|length=377bp
MKILVLAVVLFAFAWCKKKDGNNHDDILDTNQKMFERAKKGTSGFSGKKK
LIKEEDMLEGDIVLTPKLRKYLNNQRDGKAISAFDAAVSKAWPKSGPYAR
VPYTFARGFSYKSVVGQAIAEYNAKTCIRFVPRRSSDRSYVEFMHGGGCY
SMIGRVGGKQQISLGNGCGTKGVAIHEMMHALGFFHEQSRRDRDSYITIN
WNNIPGRVRYNFEKYRHGQAQTLGQPYDKKSVMHYGNYAFSTNRQKTIVS
KSNPNEVLGQRRGLSTIDIRQLKTMYKCGGVKPIPTQRPPTTGDCKDKYS
LCSTLAGQGFCRVTFTSWMKNNCKKSCKKCPTKPSLPRCKPHKNSRHCAS
WARSGYCTNRRYASFMAGHCSSCKKCI
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_044369XLOC_044369Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00071436TCONS_00071436Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001506Peptidase_M12A
IPR003582ShKT_dom
IPR006026Peptidase_Metallo
IPR024079MetalloPept_cat_dom
IPR034035Astacin-like_dom
Vocabulary: Molecular Function
TermDefinition
GO:0004222metalloendopeptidase activity
GO:0008237metallopeptidase activity
GO:0008270zinc ion binding
Vocabulary: Biological Process
TermDefinition
GO:0006508proteolysis
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006508 proteolysis
molecular_function GO:0004222 metalloendopeptidase activity
molecular_function GO:0008237 metallopeptidase activity
molecular_function GO:0008270 zinc ion binding
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001506Peptidase M12APRINTSPR00480ASTACINcoord: 226..241
score: 54.48
coord: 187..204
score: 52.87
coord: 264..277
score: 35.6
coord: 168..186
score: 49.82
coord: 115..133
score: 37.54
IPR001506Peptidase M12APFAMPF01400Astacincoord: 97..279
e-value: 2.5E-66
score: 222.8
IPR003582ShKT domainSMARTSM00254ShkT_1coord: 338..377
e-value: 3.3
score: 15.6
coord: 294..331
e-value: 7.7E-6
score: 35.4
IPR003582ShKT domainPFAMPF01549ShKcoord: 346..376
e-value: 0.015
score: 15.7
coord: 295..330
e-value: 1.8E-6
score: 28.3
IPR003582ShKT domainPROSITEPS51670SHKTcoord: 295..330
score: 13.19
IPR006026Peptidase, metallopeptidaseSMARTSM00235col_5coord: 88..231
e-value: 1.9E-43
score: 160.3
IPR024079Metallopeptidase, catalytic domainGENE3D3.40.390.10coord: 85..280
e-value: 3.9E-58
score: 196.2
IPR034035Astacin-like metallopeptidase domainCDDcd04280ZnMc_astacin_likecoord: 99..276
e-value: 6.93333E-91
score: 272.522
NoneNo IPR availableSUPERFAMILY55486Metalloproteases ("zincins"), catalytic domaincoord: 89..278

Blast
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BLAST of Putative secreted metalloproteinase vs. Swiss-Prot (Human)
Match: ASTL (Astacin-like metalloendopeptidase OS=Homo sapiens GN=ASTL PE=1 SV=4)

HSP 1 Score: 145.976 bits (367), Expect = 1.032e-39
Identity = 91/250 (36.40%), Postives = 122/250 (48.80%), Query Frame = 0 
Query:   49 KKLIKEED-----MLEGDIVLTPKLRKYLNNQRDGKAISAFDAAVSKAWPKSGP-YARVPYTFARGFSYKS--VVGQAIAEYNAKTCIRFVPRRSSDRSYVEFMHGGGCYSMIGRVGGKQQISLGNGCGTKG--VAIHEMMHALGFFHEQSRRDRDSYITINWNNIPGRVRYNFEKYRHGQAQTLGQPYDKKSVMHYGNYAFSTNRQKTIVSKSNPNEVLGQRRGLSTIDIRQLKTMYKCGGVKPIPTQR 288
            + LI EE      ++EGDI+     R                +A S  WP  G     VP+  +  +   S  V+ +A+AE+   TCIRFV      R ++  +   GC+S +GR GG Q +SL   C  KG  + +HE+MH LGF+HE +R DRD YI +NWN I      NF K    Q+  +  PYD  SVMHYG  AFS     TI     P+  +GQR  LS  DI ++  +Y C    P P  R
Sbjct:   60 QGLILEETPESSFLIEGDIIRPSPFR--------------LLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALAEFERSTCIRFV-TYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIK---SQSSNMLTPYDYSSVMHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGR 291
The following BLAST results are available for this feature:
BLAST of Putative secreted metalloproteinase vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
ASTL1.032e-3936.40Astacin-like metalloendopeptidase OS=Homo sapiens ... [more]
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