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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00046196-protein ID=TCONS_00046196-protein|Name=TCONS_00046196-protein|organism=Clytia hemisphaerica|type=polypeptide|length=944bp
MYCWQIFLFLFLCFCFCFDSISPAQAVDRYHNPCKAGCKQKDIVKITTSR
TKRAATNVKEKLWSNGIIPYTVSSNFTGNEQVTIRKAITHWESHTCIQFI
LKTQQSSYVHFQNQNNCGCSSFVGRVDENAGQGINLEAGCLTYGTVLHEL
GHVIGFWHEHMRSDSNKHLTIFRHNIQPHALKNFERKNSKEIDSLGVDYD
LGSVMHYSMDMFTKNVGSFSFVPKQPFKGVIGQREQLSQKDKLQANLLYK
CASCGKTLHQRTGEIQFPSQEMKYPSSKTSNPRSCEWRISLPHGQRLFLK
FQNVKFASKSCDESYLLLHSINKRNSSSYKLKYCHTNPPPTHLKVRNNLM
VLTIHDIGNQQSTFRMKYQDLCGGKLTTTSDIMESPNFPDNYSPGDYCEW
KIEVPRGQRILFNFNVLKLKKSPDCKKDHVEIIDTHNAEILGHFCRLRQI
GRSLLTSGSTAIVRFRSNSKKTRSGFSLQYSAEMNECLTGNGGCQHQCHD
VISRHYCSCNHGYILQSDGRSCESDCKDQIIDLSPGHQYYLRSLNYPSNY
PSRSNCRWKINALSSDSIVFQFQQIHLAGENNETCDSLSFVSTDDHGKEQ
VVQKLCGSHLTVKELTVAANHVIVHFESNNNQIPFMKRFLISVIADKNEC
LVDNGGCSHLCTNTPISYRCQCPFGFELSSDNHTCIFGSCTTTKYAHEGT
VTSPGFPNKYFGGQNCVWNIFSVPGHRVQAKVEVKKKTFNALECPLMING
DGLCNGILMKNQTYITKDNQMRIVSKFQHRHPLFKITFRSICGGKLEAKR
TWQYIHSHLEYNSRVKYGPNIDCHWTIKTKADNNVNKRVLIVFETFHIES
EPCQFDFVEIFDGVGPKAPLIAKKCGGYLRGKRIHSTGDSLKIHFKTDSS
IHKKGFRMKYKEINVRDISIKPKTTLSPIFDRRRDYFVFDLDEI Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0004222 | metalloendopeptidase activity |
| GO:0005509 | calcium ion binding |
| GO:0008237 | metallopeptidase activity |
| GO:0008270 | zinc ion binding |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0006508 | proteolysis |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0006508 |
proteolysis |
| molecular_function |
GO:0005509 |
calcium ion binding |
| molecular_function |
GO:0004222 |
metalloendopeptidase activity |
| molecular_function |
GO:0008237 |
metallopeptidase activity |
| molecular_function |
GO:0008270 |
zinc ion binding |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| IPR001506 | Peptidase M12A | PRINTS | PR00480 | ASTACIN | coord: 140..158
score: 53.77
coord: 159..176
score: 38.06
coord: 198..213
score: 47.08
coord: 84..102
score: 36.32
coord: 237..250
score: 42.62 |
| IPR001506 | Peptidase M12A | PFAM | PF01400 | Astacin | coord: 62..252
e-value: 1.1E-57
score: 194.6 |
| IPR001881 | EGF-like calcium-binding domain | SMART | SM00179 | egfca_6 | coord: 483..523
e-value: 7.3E-5
score: 32.2
coord: 646..686
e-value: 1.8E-7
score: 40.8 |
| IPR006026 | Peptidase, metallopeptidase | SMART | SM00235 | col_5 | coord: 59..203
e-value: 9.4E-38
score: 141.4 |
| IPR000742 | EGF-like domain | SMART | SM00181 | egf_5 | coord: 486..523
e-value: 0.0012
score: 28.1
coord: 649..686
e-value: 2.5E-5
score: 33.7 |
| IPR000742 | EGF-like domain | PROSITE | PS50026 | EGF_3 | coord: 483..523
score: 7.628 |
| IPR000742 | EGF-like domain | PROSITE | PS50026 | EGF_3 | coord: 646..686
score: 8.768 |
| IPR000859 | CUB domain | SMART | SM00042 | CUB_2 | coord: 690..791
e-value: 0.0055
score: 16.3
coord: 792..913
e-value: 1.4E-22
score: 91.0
coord: 526..646
e-value: 9.4E-7
score: 38.4
coord: 372..483
e-value: 1.3E-30
score: 117.7
coord: 254..371
e-value: 6.5E-4
score: 26.5 |
| IPR000859 | CUB domain | PFAM | PF00431 | CUB | coord: 690..732
e-value: 1.6E-4
score: 21.9
coord: 538..631
e-value: 5.5E-13
score: 49.1
coord: 792..910
e-value: 2.6E-18
score: 66.3
coord: 372..480
e-value: 5.8E-23
score: 81.2
coord: 254..368
e-value: 1.6E-9
score: 38.0 |
| IPR000859 | CUB domain | GENE3D | 2.60.120.290 | | coord: 371..485
e-value: 7.9E-27
score: 93.3
coord: 789..916
e-value: 1.4E-25
score: 89.2
coord: 522..644
e-value: 5.8E-17
score: 61.4 |
| IPR000859 | CUB domain | GENE3D | 2.60.120.290 | | coord: 690..788
e-value: 2.3E-7
score: 30.4 |
| IPR000859 | CUB domain | GENE3D | 2.60.120.290 | | coord: 249..370
e-value: 1.5E-16
score: 60.3 |
| IPR000859 | CUB domain | PROSITE | PS01180 | CUB | coord: 372..483
score: 23.351 |
| IPR000859 | CUB domain | PROSITE | PS01180 | CUB | coord: 792..913
score: 20.681 |
| IPR000859 | CUB domain | PROSITE | PS01180 | CUB | coord: 526..646
score: 13.293 |
| IPR000859 | CUB domain | PROSITE | PS01180 | CUB | coord: 254..371
score: 14.437 |
| IPR000859 | CUB domain | PROSITE | PS01180 | CUB | coord: 690..744
score: 9.79 |
| IPR000859 | CUB domain | CDD | cd00041 | CUB | coord: 526..631
e-value: 1.63308E-11
score: 61.6594 |
| IPR000859 | CUB domain | CDD | cd00041 | CUB | coord: 372..482
e-value: 4.85092E-26
score: 103.646 |
| IPR000859 | CUB domain | CDD | cd00041 | CUB | coord: 792..910
e-value: 4.43772E-23
score: 95.1718 |
| IPR000859 | CUB domain | CDD | cd00041 | CUB | coord: 254..369
e-value: 1.30632E-9
score: 55.8814 |
| IPR000859 | CUB domain | SUPERFAMILY | 49854 | Spermadhesin, CUB domain | coord: 536..642 |
| IPR000859 | CUB domain | SUPERFAMILY | 49854 | Spermadhesin, CUB domain | coord: 372..482 |
| IPR000859 | CUB domain | SUPERFAMILY | 49854 | Spermadhesin, CUB domain | coord: 788..912 |
| IPR000859 | CUB domain | SUPERFAMILY | 49854 | Spermadhesin, CUB domain | coord: 248..373 |
| IPR000859 | CUB domain | SUPERFAMILY | 49854 | Spermadhesin, CUB domain | coord: 689..774 |
| None | No IPR available | GENE3D | 2.10.25.10 | | coord: 645..687
e-value: 1.0E-16
score: 60.4 |
| None | No IPR available | GENE3D | 2.10.25.10 | | coord: 486..521
e-value: 8.7E-11
score: 41.6 |
| None | No IPR available | PFAM | PF14670 | FXa_inhibition | coord: 650..685
e-value: 5.1E-13
score: 49.0
coord: 487..522
e-value: 1.2E-8
score: 35.0 |
| None | No IPR available | CDD | cd00054 | EGF_CA | coord: 485..523
e-value: 0.00785474
score: 34.5346 |
| None | No IPR available | SUPERFAMILY | 55486 | Metalloproteases ("zincins"), catalytic domain | coord: 57..251 |
| None | No IPR available | SUPERFAMILY | 57196 | EGF/Laminin | coord: 483..524 |
| None | No IPR available | SUPERFAMILY | 57196 | EGF/Laminin | coord: 645..686 |
| IPR024079 | Metallopeptidase, catalytic domain | GENE3D | 3.40.390.10 | | coord: 54..248
e-value: 7.7E-55
score: 185.4 |
| IPR015446 | Bone morphogenetic protein 1/tolloid-like protein | PIRSF | PIRSF001199 | BMP1 | coord: 21..935
e-value: 2.8E-201
score: 669.0 |
| IPR013032 | EGF-like, conserved site | PROSITE | PS01186 | EGF_2 | coord: 507..522 |
| IPR013032 | EGF-like, conserved site | PROSITE | PS01186 | EGF_2 | coord: 670..685 |
| IPR000152 | EGF-type aspartate/asparagine hydroxylation site | PROSITE | PS00010 | ASX_HYDROXYL | coord: 661..672 |
Blast
BLAST of TCONS_00046196-protein vs. Swiss-Prot (Human)
Match: TLL2 (Tolloid-like protein 2 OS=Homo sapiens GN=TLL2 PE=1 SV=1) HSP 1 Score: 491.5 bits (1264), Expect = 2.776e-158 Identity = 297/900 (33.00%), Postives = 461/900 (51.22%), Query Frame = 0
Query: 44 VKITTSRTKRAATNVKEKLWSNGIIPYTVSSNFTGNEQVTIRKAITHWESHTCIQFILKTQQSSYVHFQNQNNCGCSSFVGRVDENAGQGINLEAGCLTYGTVLHELGHVIGFWHEHMRSDSNKHLTIFRHNIQPHALKNFERKNSKEIDSLGVDYDLGSVMHYSMDMFTKNVGSFSFVPKQPFKGV---IGQREQLSQKDKLQANLLYKCASCGKTLHQRTGEIQFPSQEMKYPSSKTSNPRSCEWRISLPHGQRLFLKFQNVK-FASKSCDESYLLLHSINKRNSSSYKLKYCHTNPPPTHLKVRNNLMVLTIHDIGNQQSTFRMKYQDLCGGKLTTTSDIMESPNFPDNYSPGDYCEWKIEVPRGQRILFNFNVLKLKKSPDCKKDHVEIID--THNAEILGHFCRLRQIGRSLLTSGSTAIVRFRSNSKKTRSGFSLQYSAEMNEC-LTGNGGCQHQCHDVISRHYCSCNHGYILQSDGRSCESDCKDQIIDLSPGHQYYLRSLNYPSNYPSRSNCRWKINALSSDSIVFQFQQIHLAGENNETC-----DSLSFVSTDDHGKEQVVQKLCGSHLTVKELTVAANHVIVHFESNNNQIPFMKR-FLISVIADKNECLVDNGGCSHLCTNTPISYRCQCPFGFELSSDNHTCIFGSCTTTKYAHEGTVTSPGFPNKYFGGQNCVWNIFSVPGHRVQA---KVEVKKKTFNALECPLMINGDGLCNGIL------MKNQTYITKDNQM--RIVSKFQHRHPLFKITFRSICGGKLEAKRTWQYIHSHLEYNSRVKYGPNIDCHWTIKTKADNNVNKRVLIVFETFHIESEP-CQFDFVEIFDGVGPKAPLIAKKCG-GYLRGKRIHSTGDSLKIHFKTDSSIHKKGFRMKYKEINVRD 917
K + R +RA T+ E++W G+IPY + NFTG+++ ++A+ HWE HTC+ FI +T + S++ F + CGC S+VGR Q I++ C +G V HELGHV+GFWHEH R D ++H+TI R NIQP NF + + E+ SLG YD S+MHY+ + F++ V + +P+Q GV IGQR +LSQ D QA LYKC +CG+TL TG P YPS C WRIS+ G+++ L F ++ F S+ C Y+ + R + ++C P + + L V F Y+ CGG + + ++SPN+PD+Y P C W+I V G + F ++++ C D++E+ D T + ++GHFC + + +S + ++F S+ ++GF+ + E++EC +GGC+H+C + + + C+C+ GY L +D + CE C I L+ + S +P YP+ NC W++ A + I QF+ L E N+ C + S +S D ++ + CGS T + +T +N++ V F+S+N KR F +DK+EC DNGGC H C NT SY C+C G+ L + H C C + EGT+ SP +P+KY + C WNI S GHRV+ + E+++ A + M +G IL K + + M R S + F+ + CGG+L+A+ + ++SH ++ Y C W I + V + F TF +E E C +D++E +DG AP + + CG G L + I+S GDSL I F+TD +I+KKGF +Y +D
Sbjct: 140 AKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVF-SYRTCGCCSYVGRRG-GGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYS-----HCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLG-RFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKP-EDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNG----TITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFEL--EGNDVCKYDFVEVRSGLSPD----AKLHGRFCGSE-TPEVITSQSNNMRVEFKSDNT---VSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDN-NYPSEARCDWVIVAEDGYGVE----LTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPL--EEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQD 1009
The following BLAST results are available for this feature:
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