Secreted protease (polypeptide) - C. hemisphaerica

Overview


Name	Secreted protease
Unique Name	TCONS_00045555-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	627

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00045555-protein ID=TCONS_00045555-protein|Name=Secreted protease|organism=Clytia hemisphaerica|type=polypeptide|length=627bp
MRTIWTFSFILTSLYITIFATLHHHGTGKYTNTWVVEVIDDHPDTVRKVT
EELDLHYHGPVGSLKNIHVVQHKTLESGLNRTSDEHHKKIVVHDKVLYAR
QEQILNRKKRGYIRSDPDYKKQWFLKNTGQTRHLCNGELYDINVEPVWRE
GITGRGVVVAILDDGLEYTHPDLKRNFNNVSSFNFNSRPYSRDPIPRATP
DDLNKHGTRCAGEVAAERDNGVCGRGVAYNAQVAGIRMLDGEVSDAIEAG
SLSYRRDLIDIYSSSWGPDDDGYTVDGPGRLTRRALSEGISKGRNGLGSI
FVWATGNGGGLFDYCSCDGYINSPYTISIGAVNNCGHKPWYSEPCPGTLA
VTFSSGETSRERRDLQIVTTDLHKKCTDLHTGTSAAAPLAAGIFALVLEA
NPKLTWRDLQHLIVHTSRKVHPSDSGWKENGAGLIVNENFGFGSLDAKAL
VDAARDPNWKTADTRKVYETPVKYVGLHRVPRSQSEIISKIPFSQSTNGV
CINKLEHVHAIVSLRLSKQGYRGNRGKHSIKLISPQGTESNLLLQRPRDY
FHGRGRHYAFREWEFMTVFNWDENPEGIWTLKMKDHTPYSYSSWAEKTHL
SWKLRLSGTCKQIKWPYWNFFDSHGHK

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_029131	XLOC_029131	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00045555	TCONS_00045555	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR015500	Peptidase_S8_subtilisin-rel
IPR000209	Peptidase_S8/S53_dom
IPR002884	PrprotnconvertsP
IPR032815	S8_pro-domain
IPR008979	Galactose-bd-like
IPR022398	Peptidase_S8_His-AS
IPR023828	Peptidase_S8_Ser-AS
IPR023827	Peptidase_S8_Asp-AS
IPR034182	Kexin/furin
IPR009020	Peptidase/Inhibitor_I9

Vocabulary: **Biological Process**
Term	Definition
GO:0006508	proteolysis

Vocabulary: **Molecular Function**
Term	Definition
GO:0004252	serine-type endopeptidase activity

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006508	proteolysis
molecular_function	GO:0004252	serine-type endopeptidase activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR015500	Peptidase S8, subtilisin-related	PRINTS	PR00723	SUBTILISIN	coord: 154..173 score: 48.55 coord: 381..397 score: 59.75 coord: 202..215 score: 58.18
IPR000209	Peptidase S8/S53 domain	GENE3D	3.40.50.200		coord: 108..456 e-value: 1.0E-73 score: 247.6
IPR000209	Peptidase S8/S53 domain	PFAM	PF00082	Peptidase_S8	coord: 154..443 e-value: 2.3E-47 score: 161.6
IPR000209	Peptidase S8/S53 domain	SUPERFAMILY	52743	Subtilisin-like	coord: 114..454
IPR002884	Proprotein convertase, P	PFAM	PF01483	P_proprotein	coord: 523..590 e-value: 3.6E-12 score: 46.1
IPR032815	Peptidase S8, pro-domain	PFAM	PF16470	S8_pro-domain	coord: 33..110 e-value: 2.9E-10 score: 40.8
IPR008979	Galactose-binding domain-like	GENE3D	2.60.120.260		coord: 457..614 e-value: 1.3E-21 score: 76.2
IPR008979	Galactose-binding domain-like	SUPERFAMILY	49785	Galactose-binding domain-like	coord: 464..609
None	No IPR available	GENE3D	3.30.70.850		coord: 21..107 e-value: 9.4E-16 score: 57.6
IPR022398	Peptidase S8, subtilisin, His-active site	PROSITE	PS00137	SUBTILASE_HIS	coord: 206..216
IPR023828	Peptidase S8, subtilisin, Ser-active site	PROSITE	PS00138	SUBTILASE_SER	coord: 382..392
IPR023827	Peptidase S8, subtilisin, Asp-active site	PROSITE	PS00136	SUBTILASE_ASP	coord: 159..170
IPR034182	Kexin/furin catalytic domain	CDD	cd04059	Peptidases_S8_Protein_convertases_Kexins_Furin-like	coord: 115..418 e-value: 5.95095E-164 score: 472.815
IPR009020	Protease propeptides/proteinase inhibitor I9	SUPERFAMILY	54897	Protease propeptides/inhibitors	coord: 30..102

Blast

[Close]

BLAST of Secreted protease vs. Swiss-Prot (Human)
Match: NEC1 (Neuroendocrine convertase 1 OS=Homo sapiens GN=PCSK1 PE=1 SV=2)

HSP 1 Score: 478.789 bits (1231), Expect = 1.173e-160
Identity = 269/622 (43.25%), Postives = 372/622 (59.81%), Query Frame = 0

Query:    2 RTIWTFSFILTSLYITIFATLHHHGTGKYTNTWVVEVIDDHPDTVRKVTEELDLHYHGPVGSLKNIHVVQHKTLESGLNRTSDEHHKKIVVHDKVLYARQEQILNRKKRGYIR-------SDPDYKKQWFLKNTGQTRHLCNGELYDINVEPVWREGITGRGVVVAILDDGLEYTHPDLKRNFNNVSSFNFNSRPYSRDPIPRATPDDLNKHGTRCAGEVAAERDNGVCGRGVAYNAQVAGIRMLDGEVSDAIEAGSLSYRRDLIDIYSSSWGPDDDGYTVDGPGRLTRRALSEGISKGRNGLGSIFVWATGNGGGLFDYCSCDGYINSPYTISIGAVNNCGHKPWYSEPCPGTLAVTFSSGETSRERRDLQIVTTDLHKKCTDLHTGTSAAAPLAAGIFALVLEANPKLTWRDLQHLIVHTSR-KVHPSDSGWKENGAGLIVNENFGFGSLDAKALVDAARDPNWKTADTRKVYETPVKYVGLH-RVPRSQSEIISKIPFSQSTNGV--CINKLEHVHAIVSLRLSKQGYRGNRGKHSIKLISPQGTESNLLLQRPRDYFHGRGRHYAFREWEFMTVFNWDENPEGIWTLKMKDHTPYSYSSWAEKTHLSWKLRLSGTCKQ 612
            R  W+       L+    A        ++ N W  E I   P+    + EEL     G +GSL+N ++ +HK       R++    K++   D+V++A Q+    R KR  +R       +DP + +QW+L++T  T  L      D++V PVW++GITG+GVV+ +LDDGLE+ H D+  N++  +S++FN   +  DP PR  P + NKHGTRCAGE+A + +N  CG GVAYN++V GIRMLDG V+DAIEA S+ +    +DIYS+SWGP+DDG TV+GPGRL ++A   G+ +GR G GSIFVWA+GNGG   D C CDGY +S YTISI + +  G  PWY+E C  TLA ++SSG+ + +R    I + DLH  CT+ HTGTSA+APLAAGIFAL LEANP LTWRD+QHL+V TS      ++ GWK+NGAGL+VN  FGFG L+AKALVD A    W++   +K  E  VK      R  ++  E+I +IP +++  G    I  LEHV    ++  S+      RG   + L S  GT + LL +R RD          F+ W+FM+V  W ENP G WTL++ D +    +   E   ++WKL L GT  Q
Sbjct:    3 RRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAE-IPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPK---LDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDH--DPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQR----ITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKK--ECVVKDNDFEPRALKANGEVIIEIP-TRACEGQENAIKSLEHVQFEATIEYSR------RGDLHVTLTSAAGTSTVLLAERERDTSPN-----GFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQN---EGRIVNWKLILHGTSSQ 597

The following BLAST results are available for this feature:

BLAST of Secreted protease vs. Swiss-Prot (Human)

BLAST of Secreted protease vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
NEC1	1.173e-160	43.25	Neuroendocrine convertase 1 OS=Homo sapiens GN=PCS...	[more]

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Secreted protease (polypeptide) - C. hemisphaerica