TCONS_00040616-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00040616-protein
Unique NameTCONS_00040616-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length700

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00040616-protein ID=TCONS_00040616-protein|Name=TCONS_00040616-protein|organism=Clytia hemisphaerica|type=polypeptide|length=700bp
MADLEAVLADVSYLMAMEKSKSTPAARASKKIVLPDASVYSVMHKYLNER
DEVTFDHIFNQRLGFLLFQEYCEQLCDEPVPQIKFYEAIKEYERLQSFDD
RLVRAREIFDTYIMKELLSCSHSFTLNAIEHVRKLLAVGEVPVALFEPYD
KEIKDSLRGRIFSKFLKSEKYVRYLQWKNLELNIHLTMNDFSVHRIIGRG
GFGEVYGCRKADTGKMYALKSLDKKRIKMKQGETLSLNERIMLSLVDCPF
IVCMTYAFHTPDKLCFILDLMNGGDLHYHLTQHGVFDEKSVLFYASEVIL
GLEHMHNRFICYRDLKPANILLDESGHVRISDLGLACDFSKKRPHACVGT
HGYMAPEVLQKSVAYDSSADWFSLGCMLYKLLRGHSPFRQQKTKDKHEID
KLTLTMDVKFPDEFSDVMKSLLGGLLQRNVPKRLGCQGKGSLEVKGHEYF
KDLEWKQVELLKLTPPLIPPRGEVNAADAFDIGSFDEDDVKGVKLTEEDQ
SLYKNFNYMNSERWQYEIAETVFDVVNQETEKLEAKKRGKQYMSILDINA
QNGDCLLHGFLHKLGGPFQSVWTKKYFFLYPNRLEYRGEQAVSIFNSQKI
LLPLEDIRFVDEINYKNFRCIKIVLKDNRETLVLRAESETEFTEWFKEIC
KSYEEAQVQIKAGAKILKSNSSKTLMSYNSREEVESNHSQSTHSITAIIP
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_024731XLOC_024731Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00040616TCONS_00040616Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR000239GPCR_kinase
IPR000961AGC-kinase_C
IPR016137RGS
IPR001849PH_domain
IPR000719Prot_kinase_dom
IPR011993PH_dom-like
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom
Vocabulary: Molecular Function
TermDefinition
GO:0004703G-protein coupled receptor kinase activity
GO:0005524ATP binding
GO:0004674protein serine/threonine kinase activity
GO:0004672protein kinase activity
Vocabulary: Biological Process
TermDefinition
GO:0006468protein phosphorylation
GO:0007165signal transduction
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006468 protein phosphorylation
biological_process GO:0007165 signal transduction
molecular_function GO:0005524 ATP binding
molecular_function GO:0004703 G-protein coupled receptor kinase activity
molecular_function GO:0004672 protein kinase activity
molecular_function GO:0004674 protein serine/threonine kinase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000239GPCR kinasePRINTSPR00717GPCRKINASEcoord: 171..183
score: 53.85
coord: 490..503
score: 49.66
coord: 465..482
score: 50.79
coord: 504..521
score: 38.89
coord: 230..248
score: 44.36
IPR000961AGC-kinase, C-terminalSMARTSM00133pkinase_C_6coord: 451..510
e-value: 2.7E-8
score: 43.5
IPR000961AGC-kinase, C-terminalPROSITEPS51285AGC_KINASE_CTERcoord: 451..518
score: 11.342
IPR016137RGS domainSMARTSM00315RGS_3coord: 54..175
e-value: 9.4E-25
score: 98.2
IPR016137RGS domainPFAMPF00615RGScoord: 55..173
e-value: 2.0E-15
score: 57.0
IPR016137RGS domainPROSITEPS50132RGScoord: 54..175
score: 34.604
IPR016137RGS domainSUPERFAMILY48097Regulator of G-protein signaling, RGScoord: 30..184
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 555..656
e-value: 2.3E-11
score: 53.8
IPR001849Pleckstrin homology domainPFAMPF00169PHcoord: 557..651
e-value: 4.9E-8
score: 33.3
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 554..654
score: 14.278
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 191..450
e-value: 1.8E-81
score: 286.6
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 192..437
e-value: 4.7E-68
score: 229.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 191..450
score: 42.817
NoneNo IPR availableGENE3D1.10.167.10coord: 80..158
e-value: 6.8E-28
score: 96.7
NoneNo IPR availableGENE3D1.10.510.10coord: 286..470
e-value: 6.3E-51
score: 171.8
NoneNo IPR availableGENE3D3.30.200.20coord: 163..285
e-value: 8.8E-24
score: 83.2
IPR011993PH domain-likeGENE3D2.30.29.30coord: 500..664
e-value: 4.6E-14
score: 51.8
IPR011993PH domain-likeSUPERFAMILY50729PH domain-likecoord: 551..657
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 310..322
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 197..220
IPR011009Protein kinase-like domainSUPERFAMILY56112Protein kinase-like (PK-like)coord: 187..519

Blast
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BLAST of TCONS_00040616-protein vs. Swiss-Prot (Human)
Match: ARBK2 (Beta-adrenergic receptor kinase 2 OS=Homo sapiens GN=GRK3 PE=1 SV=2)

HSP 1 Score: 944.495 bits (2440), Expect = 0.000e+0
Identity = 453/679 (66.72%), Postives = 551/679 (81.15%), Query Frame = 0 
Query:    1 MADLEAVLADVSYLMAMEKSKSTPAARASKKIVLPDASVYSVMHKYLNERDEVTFDHIFNQRLGFLLFQEYCEQLCDEPVPQIKFYEAIKEYERLQSFDDRLVRAREIFDTYIMKELLSCSHSFTLNAIEHVRKLLAVGEVPVALFEPYDKEIKDSLRGRIFSKFLKSEKYVRYLQWKNLELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYALKSLDKKRIKMKQGETLSLNERIMLSLV---DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLTQHGVFDEKSVLFYASEVILGLEHMHNRFICYRDLKPANILLDESGHVRISDLGLACDFSKKRPHACVGTHGYMAPEVLQKSVAYDSSADWFSLGCMLYKLLRGHSPFRQQKTKDKHEIDKLTLTMDVKFPDEFSDVMKSLLGGLLQRNVPKRLGCQGKGSLEVKGHEYFKDLEWKQVELLKLTPPLIPPRGEVNAADAFDIGSFDEDDVKGVKLTEEDQSLYKNFNYMNSERWQYEIAETVFDVVNQETEKLEAKKRGK-QYMSILDINAQNGDCLLHGFLHKLGGPFQSVWTKKYFFLYPNRLEYRGEQAVSIFNSQKILLPLEDIRFVDEINYKNFRCIKIVLKDNRETLVLRAESETEFTEWFKEICKSYEEAQVQIKAGAKILKSNSSKTL 675
            MADLEAVLADVSYLMAMEKSK+TPAARASK+IVLP+ S+ SVM KYL ER+E+TFD IFNQ++GFLLF+++C    +E VPQ+KFYE IKEYE+L + +DRL R+R+I+D YIMKELLSCSH F+  A+EHV+  L+  +V   LF+PY +EI +SLRG IF KF++S+K+ R+ QWKN+ELNIHLTMN+FSVHRIIGRGGFGEVYGCRKADTGKMYA+K LDKKRIKMKQGETL+LNERIMLSLV   DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL+QHGVF EK + FYA+E+ILGLEHMHNRF+ YRDLKPANILLDE GH RISDLGLACDFSKK+PHA VGTHGYMAPEVLQK  AYDSSADWFSLGCML+KLLRGHSPFRQ KTKDKHEID++TLT++V+ PD FS  +KSLL GLLQR+V KRLGC G GS EVK H +FK ++W+ V L K  PPLIPPRGEVNAADAFDIGSFDE+D KG+KL + DQ LYKNF  + SERWQ E+ ETV++ VN +T+K+EA+KR K + +   +  A   DC++HG++ KLG PF + W ++YF+L+PNRLE+RGE       S++ LL +E I  V+E   K+ +CI   +K  ++  VL+ ES+ EF +W KE+ ++++EAQ  ++   K L    S T+
Sbjct:    1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEG-----ESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQ-FVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTV 673
The following BLAST results are available for this feature:
BLAST of TCONS_00040616-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
ARBK20.000e+066.72Beta-adrenergic receptor kinase 2 OS=Homo sapiens ... [more]
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