TCONS_00020302-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00020302-protein
Unique Name	TCONS_00020302-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	634

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00020302-protein ID=TCONS_00020302-protein|Name=TCONS_00020302-protein|organism=Clytia hemisphaerica|type=polypeptide|length=634bp
MKLNVKVNELQILHLAVLAKNFPTKCGYLEKKSGKKVVDQTSVRWQRRWC
AVYYNFMFYYETESSPKPQGVILLDGVRTDELEVTELPCFGIRVARDEGR
EYLFGCESDAEREEWVQVINSSSANAIWERNDNLVHQVQALENDLQSLKE
EKERLNQELNDNYQQVTRLKLELSSVREQAMSFKNRRASAGSLITLRNEE
ESSSNSVVTASDFDIDPSDIPKIIKLQNAIRSWLLRRRWKGLIQSYISTF
TADKLKQRNQLLWQFITSEEDYVHQLNVLVGVFLHPIKQRSFNSQIISST
EVTKIFANSESILVLHKIFVEGMAMRMKDWPAVQIDDLLFSLVAAVPIYI
EYIKNHPEALKTLCECKKRPEFVKMLSWCEAKEECHGQTIEQFLLYPVRV
MPTYVRNIFEILEMTPEEHNERKALESILHKLQEAQTYNHYLDEGESIRH
TLEIERLIDGGCIDLLDGEQTFIRHGILKQIGLHEPRFPSGRREKTRHCF
LFSKHLIIASRTIDGRLRLSKNAGVVPLHHTSLAEEDIGSDFPEYMKNRA
FKLLVEIPMEEDKVHRNDIVLMANKLNEKTLWATDITQCIYNLALEDNPS
SDEEDKKSDDPDITESGKSGKXTRLIVSDLIKCW

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_011395	XLOC_011395	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00020302	TCONS_00020302	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR001849	PH_domain
IPR000219	DH-domain
IPR011993	PH_dom-like
IPR000048	IQ_motif_EF-hand-BS

Vocabulary: **Biological Process**
Term	Definition
GO:0035023	regulation of Rho protein signal transduction

Vocabulary: **Molecular Function**
Term	Definition
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0035023	regulation of Rho protein signal transduction
molecular_function	GO:0005515	protein binding
molecular_function	GO:0005089	Rho guanyl-nucleotide exchange factor activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 131..172
None	No IPR available	GENE3D	1.20.900.10		coord: 252..459 e-value: 6.2E-41 score: 139.7
None	No IPR available	GENE3D	1.20.120.330		coord: 120..230 e-value: 4.8E-5 score: 22.5
None	No IPR available	CDD	cd00160	RhoGEF	coord: 258..438 e-value: 1.31178E-24 score: 100.45
IPR001849	Pleckstrin homology domain	SMART	SM00233	PH_update	coord: 472..593 e-value: 0.0013 score: 28.0 coord: 23..126 e-value: 5.6E-18 score: 75.7
IPR001849	Pleckstrin homology domain	PFAM	PF00169	PH	coord: 24..123 e-value: 5.4E-14 score: 52.5
IPR001849	Pleckstrin homology domain	PROSITE	PS50003	PH_DOMAIN	coord: 471..591 score: 7.808
IPR001849	Pleckstrin homology domain	PROSITE	PS50003	PH_DOMAIN	coord: 22..124 score: 13.778
IPR000219	Dbl homology (DH) domain	SMART	SM00325	RhoGEF_3	coord: 261..441 e-value: 5.7E-28 score: 108.9
IPR000219	Dbl homology (DH) domain	PFAM	PF00621	RhoGEF	coord: 262..437 e-value: 1.3E-30 score: 106.9
IPR000219	Dbl homology (DH) domain	PROSITE	PS50010	DH_2	coord: 257..434 score: 23.211
IPR000219	Dbl homology (DH) domain	SUPERFAMILY	48065	DBL homology domain (DH-domain)	coord: 239..460
IPR011993	PH domain-like	GENE3D	2.30.29.30		coord: 18..119 e-value: 3.5E-21 score: 74.7
IPR011993	PH domain-like	GENE3D	2.30.29.30		coord: 460..617 e-value: 1.3E-17 score: 63.1
IPR011993	PH domain-like	SUPERFAMILY	50729	PH domain-like	coord: 21..122
IPR011993	PH domain-like	SUPERFAMILY	50729	PH domain-like	coord: 464..598
IPR000048	IQ motif, EF-hand binding site	PROSITE	PS50096	IQ	coord: 222..248 score: 6.98

Blast

[Close]

BLAST of TCONS_00020302-protein vs. Swiss-Prot (Human)
Match: RGRF2 (Ras-specific guanine nucleotide-releasing factor 2 OS=Homo sapiens GN=RASGRF2 PE=1 SV=2)

HSP 1 Score: 331.643 bits (849), Expect = 3.333e-100
Identity = 218/626 (34.82%), Postives = 337/626 (53.83%), Query Frame = 0

Query:    1 MKLNVKVNELQILHLAVLAKNFPTKCGYLEKKSGKKVVDQTSVRWQRRWCAVYYNFMFYYETESSPKPQGVILLDGV---RTDELEVTELPCFGIRVARDEGREY--LFG----------CESDAEREEWVQVINSSS-ANAIWERN---DNLVHQVQALENDLQSLKEEKERLNQELNDNYQQVTRLKLE---LSSVREQAMSFKNRRASAGSLITLRNEEESSSNSVVTASDFDIDPSDIPKIIKLQNAIRSWLLRRRWKGLIQSYISTFTADKLKQRNQLLWQFITSEEDYVHQLNVLVGVFLHPIKQRSFNSQI-ISSTEVTKIFANSESILVLHKIFVEGMAMRMKDWPAVQIDDLLFSLVAAVPIYIEYIKNHPEALKTLCECKKRPEFVKMLSWCEAKEECHGQTIEQFLLYPVRVMPTYVRNIFEILEMTPEEHNERKALESILHKLQEAQTYNH-YLDEGESIRHTLEIERLIDGGCIDLLDGEQTFIRHGILKQIG------LHEPRFP--SGRREKTRHCFLFSKHLIIASRTIDGRLRLSKNAGVVPLHHTSLAEEDIGSDFPEYMKNRAFKLL-VEIPMEEDKVHRNDIVLMANKLNEKTLWATDITQCIYNL 593
            M+ +V+ NE   L+LA LA+   TK G+L KK+ +      + RW  +W A+Y N +FY+E E S +P G+ LL+G    RT           G+R A D+   +  LFG          CE + + +EW++ I+ +S A+ + ER       +H VQ +E +    K    +L  +L D   ++ RLK E   L+  +E+   +++            N+E             D DP DI KI K+Q+ +R WL RR+WK ++Q YI +  A+ +++RNQ+++  + +E +YVHQL +LV  FL P++  + + +  IS  +V+ IF NSE+I+ LH+IF +G+  R+ +WP + + DL   L+  + IY E+++NH  +L+ L  CK+  +F K+L   EA   C G+ +E FL YP+  +P Y+  + E+L  TP EH ERK+LE    KL+E     H  + + E+IR  L IER+I  GC  LLD  QTFIR G L Q+       L + R    S ++E  R CFLF+KH +I +R+  G+L L K  GV+ L   +L EE   SD       + F  L  +I +E        +VL+A    EK  W +DI+QC+ N+
Sbjct:    1 MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAE------ASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETE----KIAANQLRHQLEDQDTEIERLKSEIIALNKTKERMRPYQS------------NQE-------------DEDP-DIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNI 590

The following BLAST results are available for this feature:

BLAST of TCONS_00020302-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00020302-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
RGRF2	3.333e-100	34.82	Ras-specific guanine nucleotide-releasing factor 2...	[more]

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TCONS_00020302-protein (polypeptide) - C. hemisphaerica