Puratrophin protein (polypeptide) - C. hemisphaerica

Overview
NamePuratrophin protein
Unique NameTCONS_00016596-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1563

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00016596-protein ID=TCONS_00016596-protein|Name=Puratrophin protein|organism=Clytia hemisphaerica|type=polypeptide|length=1563bp
MFKRLKTGVKKDTEDDQKETKKHQLPELDSGKIEGSEASLPLKSDENEEE
EDWQVICEQSLFANRLHQLEEICLQVYNGKSTDFINHFLRPVVELLDTIR
SKCEDYYELKNRKETPPWTERFENIVKYAIHPSCLRNTPLHKGDFYIHIS
ESKPRTLELKYLHGDKTQTRNLSMTDSILMCSENWAELLRSDTHDRFVFT
SCILWTSRGFEKSSWSNVLMGRLPTMMDTKDLDKPSTSTMNNNNNRRESI
INMEELAAKPILILDLNFELLHNQVAYLPGAHDRRGGPVIFFETNKSCWE
NTDMDSGELARLLIYYFKIPRESSSSLGCSLVIDARNAKQTRDILQCIGE
AILIFQEQIPGAVNMAHVLTKKDSLMLLLKASKIKENLNFEFQFISSLEK
LTREISIDELPTDFGGNLSYEHERWIKFRTKVEPFMTGCRSAAKHALHYI
KELSRTDMGSTVEECEKLLDEHRLKVNEVLEDPRLQGLRTEGRSILERIS
FEEFNAYHLTDDYKHTIECLNRLHNQMTKVFDRLQSISDRRLQSLELCLK
VRTFEEHSSQVIAWISEEGLPPLRKELIISDSLDSAEKQINEFETFTADA
EKHLDNGQQYIELGTQLTTIEDLESDRQLINEKLDELRHLCSEYSAKYAE
RSKKLTQCVNFHQLLKAAEQWWMSAMQFIANMNLEDIQTQGGIDRLKGSF
DEFTQTHPEFEESRVIKMTELAHHLGHNQVTKAEQMNKKCSDIKNMLEAK
KNQILGAEKRIQDNRNSFLYSDNDENSSGFKEDDLSTESGDHERYYDCVD
RSRGESVGSAELDDSVIIYRWRNDDELYDPNDANLVMYDSTMSPRLRERL
QHIMNELISTEIDYVGSLEYILEHYLPEMQGENVPSFLLGKKNVLFGNIE
RIYDFHKRYFSQEVESYRHQPLHIGQCFLKWERQFYLYALYNKNKPKSDE
LWNDYANAHFMKKMRELKDKLDLASYLIKPVQRLGKYSLLLEDMIKCCVE
QDPRLVELKKAHDLVKFQLRHGNDLLAMDSIRSSDVSMKDQGCLIRQADF
TIVSGRRKQERRVFLFEDLLVFAKTKKTKGKGDEFIYKQSIKMVDLGLTE
NIGESGLRFEVWYRRWKKGKATESYILQAPSASEKNDWTLAISQILWKQA
TKNKEYGLTEQSTGISVESTPSSVFYEPSTPTQHVYTRRTPVDVGKPTIM
DAPHNKRLSWISAAESSGSSGVHDLGSLPEESYGAPSPRAHENGFFFRGD
VDPKYSSLPRKKGSLGQVNQATSRSQILSDPYATANVNLRKNGSSNSGYD
GSFIRNNVYRKTFQPDGVTVNGASTPIRPPRTKKGARRRDASANGRYATQ
PVILPSNYDLGGYGPPTSHWPQKMMDVRSPAQSEMNSPLVEKKYPSSPTS
KTIQIARMSKSITDSDLSAAAIEMNKTRSNSSKSEGSGDETIKRTLSKSY
TDHNLLGRQYSKSVNDSYDSLPRDFTKRRSSFNKAMNSPDARSISVDERD
KHRRASRQLSLTNIHCSPTSPTTEKSNLELSQQSLVSPRSERKTNNSPLY
NLKARFSKSLSEM
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_009276XLOC_009276Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00016596TCONS_00016596Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR018159Spectrin/alpha-actinin
IPR001849PH_domain
IPR000219DH-domain
IPR011993PH_dom-like
IPR001251CRAL-TRIO_dom
Vocabulary: Biological Process
TermDefinition
GO:0035023regulation of Rho protein signal transduction
Vocabulary: Molecular Function
TermDefinition
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0035023 regulation of Rho protein signal transduction
molecular_function GO:0005089 Rho guanyl-nucleotide exchange factor activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 733..767
NoneNo IPR availableCOILSCoilCoilcoord: 620..640
NoneNo IPR availableCOILSCoilCoilcoord: 462..482
NoneNo IPR availableGENE3D1.20.58.60coord: 436..558
e-value: 1.0E-5
score: 25.0
NoneNo IPR availableGENE3D1.20.900.10coord: 849..1024
e-value: 6.3E-43
score: 146.1
NoneNo IPR availableGENE3D1.20.58.60coord: 559..658
e-value: 3.4E-9
score: 36.4
NoneNo IPR availableGENE3D1.20.58.60coord: 659..848
e-value: 0.44
score: 10.1
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1424..1446
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1315..1343
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..47
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1379..1401
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1479..1549
NoneNo IPR availableCDDcd00176SPECcoord: 441..659
e-value: 2.74802E-12
score: 65.93
NoneNo IPR availableCDDcd00160RhoGEFcoord: 850..1016
e-value: 3.89116E-36
score: 136.274
NoneNo IPR availableSUPERFAMILY46966Spectrin repeatcoord: 539..660
IPR018159Spectrin/alpha-actininSMARTSM00150SPEC_4coord: 552..656
e-value: 0.0041
score: 26.3
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 1038..1149
e-value: 7.2E-9
score: 45.5
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 1037..1147
score: 11.644
IPR000219Dbl homology (DH) domainSMARTSM00325RhoGEF_3coord: 853..1024
e-value: 2.3E-40
score: 150.1
IPR000219Dbl homology (DH) domainPFAMPF00621RhoGEFcoord: 853..1019
e-value: 2.1E-33
score: 116.0
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 849..1025
score: 28.931
IPR000219Dbl homology (DH) domainSUPERFAMILY48065DBL homology domain (DH-domain)coord: 849..1025
IPR011993PH domain-likeGENE3D2.30.29.30coord: 1036..1154
e-value: 1.9E-24
score: 85.6
IPR011993PH domain-likeSUPERFAMILY50729PH domain-likecoord: 1035..1153
IPR001251CRAL-TRIO lipid binding domainGENE3D3.40.525.10coord: 266..435
e-value: 1.6E-15
score: 56.7
IPR001251CRAL-TRIO lipid binding domainPROSITEPS50191CRAL_TRIOcoord: 259..422
score: 8.103
IPR001251CRAL-TRIO lipid binding domainSUPERFAMILY52087CRAL/TRIO domaincoord: 269..430

Blast
[Close]
BLAST of Puratrophin protein vs. Swiss-Prot (Human)
Match: PKHG4 (Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1)

HSP 1 Score: 445.662 bits (1145), Expect = 7.150e-134
Identity = 292/912 (32.02%), Postives = 458/912 (50.22%), Query Frame = 0 
Query:  261 ILILDLNFELLHNQVAYLPGAHDRRGGPVIFFETNKSCWENTDMDSGELARLLIYYFKIPRESSSSLGCSLVIDARNAKQTRDILQCIGEAILIFQEQIPGAVNMAHVLTKKDSLMLLLKASKIKENLNFEFQFISSLEKLTREISIDELPTDFGGNLSYEHERWIKFRTKVEPFMTGCRSAAKHALHYIKELSRTDMGSTVEECEKLLDEHRLKVNEVLEDPRLQGLRTEGRSILERISFEEFNAYHLTDDYKHTIECLNRLHNQMTKVFDRLQSISDRRLQSLELCLKVRTFEEHSSQVIAWISEEGLPPLRKELIISDSLDSAEKQINEFETFTADAEKHLDNGQQYIELGTQLTTIEDLESDRQLINEKLDELRHLCSEYSAKYAERSKKLTQCVNFHQLLKAAEQWWMSAMQFIANMNLEDIQTQGGIDRLKGSFDEFTQTHPEFEESRVIKMTELAHHLGHNQVTK-AEQMNKKCSDIKNMLEAKKNQILGAEKRIQDNRNSFLYSDNDENSSGFKEDDLSTESGDHERYYDCVDRSRGESVG--SAELDDSVIIYRWRNDDELYD--PNDANLVMYDSTMSPRLRERLQHIMNELISTEIDYVGSLEYILEHYLPEMQGENVPSFLLGKKNVLFGNIERIYDFHKRYFSQEVESYRHQPLHIGQCFLKWERQFYLYALYNKNKPKSDELWNDYANAHFMKKMRELKDKLDLASYLIKPVQRLGKYSLLLEDMIKCCVEQDPRLVELKKAHDLVKFQLRHGNDLLAMDSIRSSDVSMKDQGCLIRQADFTIVSGRRKQERRVFLFEDLLVFAKTKKTKGKGDEFIYKQSIKMVDLGLTENIGESGLRFEVWYRRWKKGKATESYILQAPSASEKNDWTLAISQILWKQATKNKEYGLTEQ-STGIS 1166
            +L  DL +ELL + +A LPG  D +G  V+    +   W  ++  S EL RLL+Y   IPR    +LG ++++DAR    +  +   + +     QE  PGAV    VL    +L+      ++   L  E Q  S  + L   I    LPT  GG L Y H+ W+ FR ++E  +  C++A       I+ +          E  +LL +  + + +VL+ P L  L+ +G   L  +  +E     L+ DY+  ++  + L++++  +  +L   S++R+Q+LEL   +   E    Q+  W+ + G P L  E     SLD   +    F+     A++ +  G+++++    LT  E  E D      +   LR   +E+S   A+R ++L       QL + A  W     + +A +     Q + G+  +          HP+   +   KM  LA  LG   + +       +C D    L+ K    L             L       S    +   +       + Y   DR+ G+S+   +     +  I   R  +      P  +  V    +  PR   RLQ ++ E+++TE +YV +LEY +E+Y PE+   +VP  L G++  LFGN+E++ DFH  +F +E+E+    P  +   FL+   QF +YALY+KNKP+SD L + Y +  F  K + L D LDLASYL+KP+QR+GKY+LLL+++ + C      L  L++A  LV FQLRHGNDLLAMD+I+  DV++K+QG L+RQ +F + +GR K  RR+FLFE+LL+F+K +      D F YK+S KM DLGLTE  G S LRFE+W+RR    KA ++++LQA S + K  WT  IS +LW+QA  NKE  + E  S G+ 
Sbjct:  180 LLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQ----LQEAAPGAVY--QVLLVGSTLL-----KEVPSGLQLE-QLPS--QSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLK-QEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPAL--EEAGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQ---PLTGWEAAELDPP--GARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELE----QERPGV--VLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLK------------LPPVGSTASLCVSQVPAAPAHPPLRKAYS-FDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRR---RKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVG 1047
The following BLAST results are available for this feature:
BLAST of Puratrophin protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
PKHG47.150e-13432.02Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1[more]
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