TCONS_00013174-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00013174-protein
Unique Name	TCONS_00013174-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1232

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00013174-protein ID=TCONS_00013174-protein|Name=TCONS_00013174-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1232bp
MSKQMKGKFKSMFGKKPSGAPFDKESCKSIITREILKDIDRSQPILQRIR
NLKELSEVVTVKVMEEHEIEALLFTVNDLLDKSISGDGRQAALQFLIAIT
NGQNERLGILRSHIFRVIVEHDVQEDLQFRIALLKVLTDDGKKLDYCEQI
GPFLDGLMEEALDSPNAVAFLEYLVKIVHYHSSFLDKSIVCSIVSKTCDF
CNNANGEQDIESSLLLLDATVRYGGLPAEGLLPLIETLCRTVNIERFCQS
SWKLMRNLIGTKLGHTAVFIMCQILEDNHHILDVILLRGAVFFIGMSIWG
SKRVASLRYSPLHVLSSFKVCLQCNHHLVAXPLHVLSSFKVCLQCNHHLV
AHEVVLSLQRLVKKFGEEQEIITWDILMDIVENILHMIDRGDADKTSILF
KQTHELLTNTEALYVEEKFYGSAERFFKILTNCAKDRPEESISTILGYYE
DRIDPNTVEWSDIFEQILITNLKQETRSGVKVRVLETIKNIYSRYRHRHE
DDILSYILHGHVSDMVYDNDKDIRKSVGYLLSYILKHCCADKYPEVLKVV
AEFLSYISLGKDVTRFNVMEDISIVVDALINTFESRLFEPSNIYIVGMLE
ILIKHLNDHFTINITSIAAGKIRRKIFELLLALRSNEYHFLGIKLKENGV
KFSTHAIFKPLDSEIFNNSASRPYFVDFDFQQAFEGLLKCLKNELDWNVL
ELVLKSIVKQLEDKNLYVYCQCNMNKLCAVLCTIINDKTFFNKMKNVPTT
MTMSELRNLIFPILSTLSTYHSYLVKDRQVELLTSIEFGLQTRSALTCVS
CLTVCVLEMQGIMKRILPSMLVKLSQIASSEMMSNAILKFLSTLKEIPSL
YSNFVEEQYMSIFAMALPYTDCLKYTRYIVTLAHQVIADWFTRCKLMFRK
DFVSIIVAALKSHTTEKDERDSMELQKDMTDVCLDMMARYSFSLHRGQPK
RSALVDFLLSQGSSQTWLVGNMLVTVTTSNTENEQCDCYKWKNKKYSMDL
DSSGNGFKFDHRHQRPHYHHEVNEDSRAESSTKPINLTKLTQKIVEQNNS
FSPSEKLLFSRQGSKAVDGIIEDDEESESGSEHAEDEHQHFILNDQSNEE
EHQPIFYPDNPPLQKENSENTQNLPLNGRDDVMKKQHDKEASPTLRPPRS
SNVSLTPPSPTKIDCYCVCSGWAEIVIQRPTGKISWLMKLENRELMNLED
FSDLLLLRKSLERENTXGRFFGFVVVEKKFRT

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_007355	XLOC_007355	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00013174	TCONS_00013174	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR003913	Tuberin
IPR011989	ARM-like
IPR024584	Tuberin_N
IPR018515	Tuberin-type_domain
IPR016024	ARM-type_fold

Vocabulary: **Molecular Function**
Term	Definition
GO:0005096	GTPase activator activity
GO:0005488	binding

Vocabulary: **Biological Process**
Term	Definition
GO:0032007	negative regulation of TOR signaling
GO:0043547	positive regulation of GTPase activity

Vocabulary: **Cellular Component**
Term	Definition
GO:0033596	TSC1-TSC2 complex

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0032007	negative regulation of TOR signaling
biological_process	GO:0043547	positive regulation of GTPase activity
cellular_component	GO:0033596	TSC1-TSC2 complex
molecular_function	GO:0005488	binding
molecular_function	GO:0005096	GTPase activator activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR003913	Tuberin	PRINTS	PR01431	TUBERIN	coord: 697..718 score: 40.91 coord: 878..898 score: 71.43 coord: 832..852 score: 47.62 coord: 284..302 score: 63.16 coord: 204..223 score: 50.0 coord: 672..692 score: 28.57
IPR011989	Armadillo-like helical	GENE3D	1.25.10.10		coord: 45..399 e-value: 0.0022 score: 15.2 coord: 400..983 e-value: 2.3E-12 score: 44.9
IPR024584	Tuberin, N-terminal	PFAM	PF11864	DUF3384	coord: 47..489 e-value: 1.5E-66 score: 225.2
IPR018515	Tuberin-type domain	PFAM	PF03542	Tuberin	coord: 568..896 e-value: 4.2E-88 score: 295.7
IPR016024	Armadillo-type fold	SUPERFAMILY	48371	ARM repeat	coord: 69..241 coord: 321..608
IPR016024	Armadillo-type fold	SUPERFAMILY	48371	ARM repeat	coord: 675..920 coord: 503..639

Blast

[Close]

BLAST of TCONS_00013174-protein vs. Swiss-Prot (Human)
Match: TSC2 (Tuberin OS=Homo sapiens GN=TSC2 PE=1 SV=2)

HSP 1 Score: 569.311 bits (1466), Expect = 4.461e-177
Identity = 326/951 (34.28%), Postives = 525/951 (55.21%), Query Frame = 0

Query:    5 MKGKFKSMFG---KKPSGAPFDKESCKSIITREILKDIDRSQPILQRIRNLKELSEVVTVKVMEEHEIEALLFTVNDLLDKSISGDGRQAALQFLIAITNGQNERLGILRSHIFRVIVEHDVQEDLQFRIALLKVLTDDGKKLDYCEQ-IGPFLDGLMEEALDSPNAVAFLEYLVKIVHYHSSFLDKSIVCSIVSKTCDFCNNANGEQDIESSLLLLDATVRYGGLPAEGLLPLIETLCRTVNIERFCQSSWKLMRNLIGTKLGHTAVFIMCQILEDNHHILDVILLRGAVFFIGMSIWGSKRVASLRYSPLHVLSSFKVCLQCNHHLVAXPLHVLSSFKVCLQCNHHLVAHEVVLSLQRLVKKFGEEQEIITWDILMDIVENILHMIDRGDADKTSILFKQTHELLTNTEALYVEEKFYGSAERFFKILTNCAKDRPEESISTILGYYEDRIDPNTVEWSDIFEQILITNLKQETRSGVKVRVLETIKNIYSRYRHRHEDDILSYILHGHVSDMVYDNDKDIRKSVGYLLSYILKHCCADKYPEVLKVVAEFLSYISLG-------KDVTRFNV-MEDISIVVDALINTFESRLFEPSNIYIVGMLEILIKHLNDHFTINITSIAAGKIRRKIFELLLALRSNEYHFLGIKLKENGVKFSTHAIFKPLDSEIFN-NSASRPY-----------------FVDFDFQQAFEGLLKCLKNELDWNVLELVLKSIVKQLEDKNLYVYCQCNMNKLCAVLCTIINDKTFFNKMKNVPTTMTMSELRNLIFPILSTLSTYHSYLVKDRQVELLTSIEFGLQTRSALTCVSCLTVCVLEMQGIMKRILPSMLVKLSQIASSEMMSNAILKFLSTLKEIPSLYSNFVEEQYMSIFAMALPYTDCLKYTRYIVTLAHQVIADWFTRCKLMFRKDFVSIIVAALKSH-------TTEKD 918
            +K KFK + G    +P+    + +  + IIT EIL+++     +  RIR + ++ EV   K  EEH +EAL   V DLL      + R A L  L AI  GQ ERLG+LR+  F+VI ++   EDL  R+ + K LTD+G+ + Y E+ +  F+   M+  L S     FL  LV +V ++S +LD+ I   +V   C  C       DIE SL +LDA V Y  LPAE L   I TLCRT+N++  C+  WKLMRNL+GT LGH+A++ MC ++ED  ++ D  LLRGAVFF+GM++WG+ R+ SLR SP                       VL SF   + C + +V++E+VLS+ RL+KK+ +E +++ WDIL++I+E +L  +   D+ +   +    H+LLT  E L  + +F+GS ER+F+++  CA  RPE S+  ++ Y    I P    W    + ++    + E+R  V+++VL+ +  +    R  +E+++++ ++   +S +  D D  +RK    LL  + + C    +  +L ++ + ++  SL        +DV  ++  +ED+   V  L+   +++L+     +   + E+L+ H+  H+  + T   A  IR + F+ LL LR++  H LG+  K+  V+FS + +   ++ E  +    S P                       +   F  LL+CLK E DW VL+LVL  + + L  K L     C++++LC+ LC++++      +++  P   + ++L   + P+L+ L +YH+YL K +Q E++  +E GL  R A  CV  L++C +EM  I+ + LP ++VKL+ I+++  M+  +L+FLSTL  +P LY NF  EQY S+FA++LPYT+  K+ +YIV LAH VIA WF RC+L FRKDFV  I   L+S+       T EKD
Sbjct:   11 LKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSS----EFLLVLVNLVKFNSCYLDEYIA-RMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSP---------------------TSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTI---VHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMAR-SLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKD 931

The following BLAST results are available for this feature:

BLAST of TCONS_00013174-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00013174-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
TSC2	4.461e-177	34.28	Tuberin OS=Homo sapiens GN=TSC2 PE=1 SV=2	[more]

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TCONS_00013174-protein (polypeptide) - C. hemisphaerica