TCONS_00012724-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00012724-protein
Unique NameTCONS_00012724-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length554

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00012724-protein ID=TCONS_00012724-protein|Name=TCONS_00012724-protein|organism=Clytia hemisphaerica|type=polypeptide|length=554bp
MEEKTDERTYEDAIQRLNNLQTNASVLANMKKEKEIGKKHLESLPAMRKF
LERSKIDVNKLDRLNIIHVSGTKGKGSVCAFCESILRQYGLKTGFYSSPH
LVEVGERIRINGKPLDRDLFTKYFFQLYDRLSETAVEHDGVMPGYFRFLT
LMAFHVYLQENVDVAVLEVGLGGTYDCTNVINTPIVCGITKLEIDHAAVL
GKEIHQIAAHKAGIMKPDRPAITIEQVKEAEDVLFEKSKEIKTPLYRIPR
LKDFQENIEDFGIKGHHQEVNAVMAIQLARVWCYEKQDILQQRCPEKVEE
LRSIITKSPYENADDESRLDAFNLPPSFIQGLAEAKWLGRCQYHRKDDNF
SYFLDGAHTKSSVEAFISWYLEVSGKYCEGFENISKILVFFITGERDSDI
ILKKLSVIDFEYVVFCPTIFDEKLTNANSDLTNYNRSRDGRLRKCFELEQ
KWLLMNVEGEEEQMETTTGLVNSTQKNSQGVSSSKTGVFPSITSAMKWIK
YSKEQRDEKPPMNDEYNPDYPIELQHSDHVQVLVTGSLHLVGGILKFLGP
GSYQ
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_007136XLOC_007136Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00012724TCONS_00012724Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR023600Folylpolyglutamate_synth_euk
IPR001645Folylpolyglutamate_synth
IPR013221Mur_ligase_cen
IPR018109Folylpolyglutamate_synth_CS
IPR004101Mur_ligase_C
Vocabulary: Molecular Function
TermDefinition
GO:0004326tetrahydrofolylpolyglutamate synthase activity
GO:0005524ATP binding
GO:0016874ligase activity
Vocabulary: Biological Process
TermDefinition
GO:0009396folic acid-containing compound biosynthetic process
GO:0009058biosynthetic process
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0009058 biosynthetic process
biological_process GO:0009396 folic acid-containing compound biosynthetic process
molecular_function GO:0005524 ATP binding
molecular_function GO:0016874 ligase activity
molecular_function GO:0004326 tetrahydrofolylpolyglutamate synthase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 10..30
NoneNo IPR availableGENE3D3.90.190.20coord: 339..554
e-value: 5.1E-27
score: 94.4
IPR023600Folylpolyglutamate synthase, eukaryotaPIRSFPIRSF038895FPGScoord: 1..552
e-value: 8.2E-148
score: 490.9
IPR001645Folylpolyglutamate synthetaseTIGRFAMTIGR01499TIGR01499coord: 46..547
e-value: 1.2E-94
score: 315.9
IPR013221Mur ligase, centralGENE3D3.40.1190.10coord: 9..337
e-value: 1.7E-74
score: 250.0
IPR013221Mur ligase, centralSUPERFAMILY53623MurD-like peptide ligases, catalytic domaincoord: 44..285
IPR018109Folylpolyglutamate synthetase, conserved sitePROSITEPS01012FOLYLPOLYGLU_SYNT_2coord: 166..181
IPR018109Folylpolyglutamate synthetase, conserved sitePROSITEPS01011FOLYLPOLYGLU_SYNT_1coord: 67..90
IPR004101Mur ligase, C-terminalSUPERFAMILY53244MurD-like peptide ligases, peptide-binding domaincoord: 486..548
coord: 337..433

Blast
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BLAST of TCONS_00012724-protein vs. Swiss-Prot (Human)
Match: FOLC (Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens GN=FPGS PE=1 SV=3)

HSP 1 Score: 404.445 bits (1038), Expect = 5.225e-135
Identity = 235/571 (41.16%), Postives = 323/571 (56.57%), Query Frame = 0 
Query:   10 YEDAIQRLNNLQTNASVLANMKKEKEIGKKHLESLPAMRKFLERSKIDVNKLDRLNIIHVSGTKGKGSVCAFCESILRQYGLKTGFYSSPHLVEVGERIRINGKPLDRDLFTKYFFQLYDRLSETAVEHDGVMPGYFRFLTLMAFHVYLQENVDVAVLEVGLGGTYDCTNVINTPIVCGITKLEIDHAAVLGKEIHQIAAHKAGIMKPDRPAITIEQVKEAEDVLFEKSKEIKTPLYRIPRLKDFQENIED--FGIKGHHQEVNAVMAIQLARVWCYEKQDILQQRCPEKVEE-LRSIITKSPYENADDESRLDAFNLPPSFIQGLAEAKWLGRCQYHRKDDNFSYFLDGAHTKSSVEAFISWYLEVSGKYCEGFENIS-----KILVFFITGERDSDIILKKLSVIDFEYVVFCPTIFDEKLTNANSDLTNYNRSRDGRLRKCFELEQKWLLMNVEGEEEQMETTTGLVNSTQKNSQG----------VSSSKTGVFPSITSAMKWIKYSKEQRDE--KPPMNDEYNPDYPIE------LQHSDHVQVLVTGSLHLVGGILKFLGPGSYQ 554
            Y+DA++ LN LQTNA  L  +K+++   +  LE   AM  +L RS + V  LDRLNIIHV+GTKGKGS CAF E ILR YGLKTGF+SSPHLV+V ERIRING+P+  +LFTKYF++LY RL ET       MP YFRFLTLMAFHV+LQE VD+AV+EVG+GG YDCTN+I  P+VCG++ L IDH ++LG  + +IA  K GI K   PA T+ Q +    VL +++++I  PLY  P L+  +E       G++G HQ  NA +A+QLA  W  ++QD      P+     L   +  +P        RL           GL   +W GR Q  R+    +++LDGAHT SS +A + W+ +      +G E  S     ++L+F  TG+RD   +LK L    F+Y VFCP +  E  +  N+D  N+  + D  L +C E +Q W  ++    EEQ         S +                 S+ + VF  I+ A++WI    + RD   +PP   +    +P+       L+ +  + VLVTGSLHLVGG+LK L P   Q
Sbjct:   45 YQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLE---AMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCW-LQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRL-----------GLRNTEWPGRTQVLRRGP-LTWYLDGAHTASSAQACVRWFRQA----LQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNL-TEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLD----EEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWI---SQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ 587
The following BLAST results are available for this feature:
BLAST of TCONS_00012724-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
FOLC5.225e-13541.16Folylpolyglutamate synthase, mitochondrial OS=Homo... [more]
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