TCONS_00012245-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00012245-protein
Unique Name	TCONS_00012245-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1437

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00012245-protein ID=TCONS_00012245-protein|Name=TCONS_00012245-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1437bp
MKYICNFLSLASRRSSRQSSERKSSRKKALEKIKKNRETGEKIEYEFEDE
KDIYDVVDEDKYAKIVQERQEEDFIVDDDGTGYADDGREIFDDDPNEIPD
KEFEKLKKTKKESSKGGKTMKNNTITTMFSAIGNKKKKEKNVTLEGDQVL
EDILNNMSTSKKASTGASKTPKRLAKHPPRRLQDEEGKKKKIMLKKTAGV
TPTNKFKIKKEPEQKDFNRNDIEMPENDDIIEDFSQDPQPYDQAQDEDVK
PKPKEEIEDFDDDFDDEALMELDESNLQNDSGINSQSQDSEETKTSQEWK
TFAEEEEVIPNIDLSGSSLPLQDCNGEKVLRFFWLDAYEDRYNQPGTIFL
FGKVFIESSKTHVSCCVTVRNIDRQVFILPRKTRHDKHGRDLGTPVEFKD
VYEEFDQKVTNKYNIQEFKCKKVEKKYSFDKVDVPKTEDYLQVIYANNKE
AQQLPADLKGETFSHVFGTNTSSLELLFLNQKIQGPGWLNIKYPQPPKTQ
LSWCKIEAVVEKPSFVTLVEETVPAPPLTVLSLSLVATTQGKSHSHEIIS
ISGLVHNEIHLEKGAPKQQFKQSFCFVTKTSDQLLPYDFQSTLKKKNANI
QVSPNERAMLGLFLAKIQQIDPDVLVGHDIHGFDLDVLLGRFTATKVPFW
SKIGRLKRNQVPKSSGKFGTSDKSPACGRLVCDIKISAKELIRCKSYDLK
ELVSVILNKERNDLLPEDIPVKLRKTDTLMSMIWENRMDAIYNLQIMYEL
NILPLAYQITCICGNVMSRTLLGGRSERNEFLLLHAFSKKNYILPDKSYN
QKHIHATEHEEENDEIAPTQTQATQSTQKQGASKKRSKGRKKPAYAGGLV
LEPKKGFYDKFILLLDFNSLYPSIIQEYNICFTTIAREMKKSVIEGEELL
PDVPESGLEFGILPTEIKRLVERRRQVKKLLKTVSEGSELYLQYDIRQKA
LKLTANSMYGCLGFSHSRFYAKPLAALVTGKGREILMKTKDLASNLGLDV
IYGDTDSIMINTNCDDWNEVRKIGTKVKQEVNKLYKMIEIDIDGIFKSML
LLKKKKYAAVMILDRKPDGTFVEKREMKGLDIVRRDWSDLAKDAGNYVLG
EILSAKSRDVIVENIHDYLRNLKDQIDNDQVDQAKYEIHKSLTKNPEEYP
DKKSLPHVTVALRLKTQGRRVAVGDTISYVICDDSSKLAATQRAYHLEEL
TKSTSLKIDKQYYLSSQIHPVVSRLCDPIEGTDATFIAESLGLDPTQYKS
AANHHGGDDPNVSVLMTDEERFKDVDKFYIKCSNKACTESLSEFKGSQDT
KEDPLNCSQCKQDYKMNHVRNALRLFIREKQHKYYNCWLQCDDQTCGHLS
RHISVKNFKNAHICQQCHRGNLRIEYTDSALYNQFLYLSIIFDISKSNEH
RQSRASGKGEEWITLHKEVEKVLHNNAYRNVNMSNLF

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_006898	XLOC_006898	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00012245	TCONS_00012245	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR006172	DNA-dir_DNA_pol_B
IPR012337	RNaseH-like_dom
IPR023211	DNA_pol_palm_dom
IPR024647	DNA_pol_a_cat_su_N
IPR015088	Znf_DNA-dir_DNA_pol_B_alpha
IPR006134	DNA-dir_DNA_pol_B_multi_dom
IPR006133	DNA-dir_DNA_pol_B_exonuc
IPR017964	DNA-dir_DNA_pol_B_CS

Vocabulary: **Molecular Function**
Term	Definition
GO:0003676	nucleic acid binding
GO:0000166	nucleotide binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0001882	nucleoside binding
GO:0003677	DNA binding
GO:0008408	3'-5' exonuclease activity

Vocabulary: **Biological Process**
Term	Definition
GO:0006260	DNA replication

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006260	DNA replication
molecular_function	GO:0008408	3'-5' exonuclease activity
molecular_function	GO:0003677	DNA binding
molecular_function	GO:0003887	DNA-directed DNA polymerase activity
molecular_function	GO:0003676	nucleic acid binding
molecular_function	GO:0001882	nucleoside binding
molecular_function	GO:0000166	nucleotide binding

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR006172	DNA-directed DNA polymerase, family B	PRINTS	PR00106	DNAPOLB	coord: 862..875 score: 60.18 coord: 1000..1008 score: 75.87 coord: 948..960 score: 56.49
IPR006172	DNA-directed DNA polymerase, family B	SMART	SM00486	polmehr3	coord: 526..1014 e-value: 6.5E-122 score: 421.0
IPR012337	Ribonuclease H-like domain	GENE3D	3.30.420.10		coord: 526..751 e-value: 1.1E-40 score: 138.6
IPR012337	Ribonuclease H-like domain	SUPERFAMILY	53098	Ribonuclease H-like	coord: 413..787
IPR023211	DNA polymerase, palm domain	GENE3D	3.90.1600.10		coord: 850..1082 e-value: 1.9E-63 score: 213.6
IPR024647	DNA polymerase alpha catalytic subunit, N-terminal domain	PFAM	PF12254	DNA_pol_alpha_N	coord: 30..92 e-value: 2.2E-19 score: 69.2
IPR015088	Zinc finger, DNA-directed DNA polymerase, family B, alpha	PFAM	PF08996	zf-DNA_Pol	coord: 1266..1437 e-value: 3.9E-33 score: 114.7
IPR006134	DNA-directed DNA polymerase, family B, multifunctional domain	PFAM	PF00136	DNA_pol_B	coord: 760..1229 e-value: 3.3E-125 score: 418.3
None	No IPR available	TIGRFAM	TIGR00592	TIGR00592	coord: 46..1226 e-value: 0.0 score: 1221.8
None	No IPR available	GENE3D	3.30.342.10		coord: 333..500 e-value: 0.02 score: 14.2
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 155..253
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 274..297
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 808..841
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 75..122
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 14..35
None	No IPR available	CDD	cd05532	POLBc_alpha	coord: 843..1244 e-value: 0.0 score: 666.974
None	No IPR available	CDD	cd05776	DNA_polB_alpha_exo	coord: 526..758 e-value: 1.84329E-84 score: 275.645
None	No IPR available	SUPERFAMILY	90234	Zinc finger domain of DNA polymerase-alpha	coord: 1338..1373
None	No IPR available	SUPERFAMILY	56672	DNA/RNA polymerases	coord: 838..1243 coord: 790..797
IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain	PFAM	PF03104	DNA_pol_B_exo1	coord: 360..701 e-value: 4.3E-51 score: 173.9
IPR017964	DNA-directed DNA polymerase, family B, conserved site	PROSITE	PS00116	DNA_POLYMERASE_B	coord: 1002..1010

Blast

[Close]

BLAST of TCONS_00012245-protein vs. Swiss-Prot (Human)
Match: DPOLA (DNA polymerase alpha catalytic subunit OS=Homo sapiens GN=POLA1 PE=1 SV=2)

HSP 1 Score: 1229.54 bits (3180), Expect = 0.000e+0
Identity = 700/1489 (47.01%), Postives = 950/1489 (63.80%), Query Frame = 0

Query:    9 SLASRRSSRQSSERKSSRKKALEKIKKNRETGEKIEYEFEDEKDIYDVVDEDKYAKIVQERQEEDFIVDDDGTGYADDGREIFDDDPNEIPDKEFEKLKKTK-----KESSKGGKTMKNNTITTMFSAIGNKKKKEKNVTLEGDQVLEDILNNMSTS-------------KKASTGASKTPKRLAKHPPRRLQDEEGKKKKIMLKKTAGVTPT---------NKFKIKKEPEQKDFNRNDIEMPENDDIIEDFSQDPQPYDQAQDEDVKPKPKEEIEDFDDDFDDEALMELDESNLQNDSGINSQSQDSEETKTSQEWKTFAEEEEV--IPNIDLSGSSLPL-QDCNGEKVLRFFWLDAYEDRYNQPGTIFLFGKVFIESSKTHVSCCVTVRNIDRQVFILPRKTRHDKH-GRDLGTPVEFKDVYEEFDQKVTNKYNIQEFKCKKVEKKYSFDKVDVPKTEDYLQVIYANNKEAQQLPADLKGETFSHVFGTNTSSLELLFLNQKIQGPGWLNIKYPQPPKTQLSWCKIEAVVEKPSFVTLVEETVPAPPLTVLSLSLVATTQGKSHSHEIISISGLVHNEIHLEKGAPKQQFKQSFCFVTKTSDQLLPYDFQSTLKKKNANIQVSPNERAMLGLFLAKIQQIDPDVLVGHDIHGFDLDVLLGRFTATKVPFWSKIGRLKRNQVPKSSGKFGTSDKSPACGRLVCDIKISAKELIRCKSYDLKELVSVILNKERNDLLPEDIPVKLRKTDTLMSMIWENRMDAIYNLQIMYELNILPLAYQITCICGNVMSRTLLGGRSERNEFLLLHAFSKKNYILPDKSYNQKHIHATEHEEENDEIAPTQTQATQSTQKQGASKKRSKGRKKPAYAGGLVLEPKKGFYDKFILLLDFNSLYPSIIQEYNICFTTIAR---EMKKSVIEGE-ELLPDVPESGLEFGILPTEIKRLVERRRQVKKLLKTVSEGSELYLQYDIRQKALKLTANSMYGCLGFSHSRFYAKPLAALVTGKGREILMKTKDLASNLGLDVIYGDTDSIMINTNCDDWNEVRKIGTKVKQEVNKLYKMIEIDIDGIFKSMLLLKKKKYAAVMILDRKPDGTFVEKREMKGLDIVRRDWSDLAKDAGNYVLGEILSAKSRDVIVENIHDYLRNLKDQIDNDQVDQAKYEIHKSLTKNPEEYPDKKSLPHVTVALRLKTQ-GRRVAVGDTISYVICDDSSKLAATQRAYHLEELTKSTSLKIDKQYYLSSQIHPVVSRLCDPIEGTDATFIAESLGLDPTQYKSAANHHGGDDPNVSVL-----MTDEERFKDVDKFYIKCSNKAC-TESLSE--FKGSQDTKEDPL-NCSQ--CKQDYKMNHVR--NALRLFIREKQHKYYNCWLQCDDQTCGHLSRHISVKNFKNAHICQQCHRGNLRIEYTDSALYNQFLYLSIIFDISKSNE-----------HRQSRASGKGEEWITLHKEVEKVLHNNAYRNVNMSNLF 1437
            S  S R+ R+   +K  R++ALE++KK +  GEK +YE ED   +Y+ VDE++Y+K+VQ RQ++D+IVDDDG GY +DGREIFDDD  +      EK K  K     K + K     K N I +MF A   KK  +K V L  D +L DIL +++T              KK S GAS  P   + H    +    GK    + +K   +TP          +  +++   E+++    + E  + D+ +E    D +P   A+  D + +P EE++                   + DSG  + S           W    E +    +  + +  S LPL +  + E+V  F+WLDAYED+YNQPG +FLFGKV+IES++THVSCCV V+NI+R ++ LPR+ + D + G++ GTP+  KDVYEEFD+K+  KY I +FK K VEK Y+F+  DVP+  +YL+V Y+   E  QLP DLKGETFSHVFGTNTSSLEL  +N+KI+GP WL +K PQ     +SWCK+EA+  KP  V ++++  P PPL V++ S+      K+H +EII+++ LVH+   L+K APK  F+  FC V+K  D + PY F+  ++KKN  ++V+  ER +LG FLAK+ +IDPD++VGH+I+GF+L+VLL R    K P WSKIGRLKR+ +PK  G+ G  +++  CGR++CD++ISAKELIRCKSY L ELV  IL  ER  +  E+I     ++  L+ ++     DA + LQIM ELN+LPLA QIT I GN+MSRTL+GGRSERNEFLLLHAF + NYI+PDK   +K               P Q    +  +  G + K  KGRKK AYAGGLVL+PK GFYDKFILLLDFNSLYPSIIQE+NICFTT+ R   E +K   +GE E +P++P+  LE GILP EI++LVERR+QVK+L+K      +L LQYDIRQKALKLTANSMYGCLGFS+SRFYAKPLAALVT KGREILM TK++   + L+VIYGDTDSIMINTN  +  EV K+G KVK EVNKLYK++EIDIDG+FKS+LLLKKKKYAA ++++   DG +V K+E+KGLDIVRRDW DLAKD GN+V+G+ILS +SRD IVENI   L  + + + N  V  +++EI+K+LTK+P++YPDKKSLPHV VAL + +Q GR+V  GDT+SYVIC D S L A+QRAY  E+L K  +L ID QYYL+ QIHPVV+R+C+PI+G DA  IA  LGLDPTQ++   +H+  D+ N ++L     +TDEE+++D ++F  KC    C TE++ +  F GS    E  L  CS   CK       V+  N L + IR    KYY+ WL C++ TC + +RH+ ++  +   +C  C +  L+ EY+D +LY Q  +   IFD   + E            +Q       +++  L    E+ L  + Y  VN+S LF
Sbjct:   15 SFVSSRARREKKSKKG-RQEALERLKKAK-AGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNP--FSVHTATAVPS--GKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPM-AAKAWDKESEPAEEVKQ------------------EADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYS--AEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSP-PPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRK---------------PQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAA-LVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFR--VHHYHKDEENDALLGGPAQLTDEEKYRDCERF--KCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLF 1455

The following BLAST results are available for this feature:

BLAST of TCONS_00012245-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00012245-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
DPOLA	0.000e+0	47.01	DNA polymerase alpha catalytic subunit OS=Homo sap...	[more]

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TCONS_00012245-protein (polypeptide) - C. hemisphaerica