prolyl 4-hydroxylase (polypeptide) - C. hemisphaerica

Overview
Nameprolyl 4-hydroxylase
Unique NameTCONS_00009213-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length542

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00009213-protein ID=TCONS_00009213-protein|Name=prolyl 4-hydroxylase|organism=Clytia hemisphaerica|type=polypeptide|length=542bp
KKDKEKMRIILQILFLVILLFETEAKSKSEEYQKPKHDFFTSASDMEVLL
NVEKKLSKKFLRYVRKEEERLDKLEDEIRNIEDGWPQPGRSKAQWLSHVT
NSYTILKRFSTFWPKIGDFSKSNTTKDHMLRLFSDLSRIKESLPAEEDMK
GALNAVFRLQDTYDLPAADFIDGLGGDRAHKLSVEEIFEIGFLCVGINDH
YHAQQWLNEALNRFPVGIQQVGFLDRISLLEYLAWSEYHLGHLEQAVNLT
AQIVHIDPTHKSAPINLELYQHDLKASQFNPNIRKKVFRREKDWQTRHNN
LCNGKEVMEQEIIDKLYCEFDNKRHPRFILKPLKVEHLYNEPGLTMYHDL
LRDWEIDAVKEKARPLLKRATVHDPKTGELVFADYRISKSAWLKPEMDQI
ANHVINKVGDVINLDMRYSESLQVQNYGLAGQYEPHFDHSTVRTPKQFKE
LGGNRIATMLLYMSEVERGGATIFVNTGPGVAIWPEKGAGVFWYNLLRNG
DGDKKTRHAGCPVLVGHKWVSNLWIHEHGQEFRRQCSLNMHE
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_005173XLOC_005173Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00009213TCONS_00009213Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR006620Pro_4_hyd_alph
IPR013547Pro_4_hyd_alph_N
IPR005123Oxoglu/Fe-dep_dioxygenase
IPR011990TPR-like_helical_dom
Vocabulary: Molecular Function
TermDefinition
GO:0005506iron ion binding
GO:0031418L-ascorbic acid binding
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0004656procollagen-proline 4-dioxygenase activity
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016491oxidoreductase activity
GO:0005515protein binding
Vocabulary: Biological Process
TermDefinition
GO:0055114oxidation-reduction process
Vocabulary: Cellular Component
TermDefinition
GO:0005783endoplasmic reticulum
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0055114 oxidation-reduction process
cellular_component GO:0005783 endoplasmic reticulum
molecular_function GO:0005506 iron ion binding
molecular_function GO:0031418 L-ascorbic acid binding
molecular_function GO:0016491 oxidoreductase activity
molecular_function GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
molecular_function GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
molecular_function GO:0004656 procollagen-proline 4-dioxygenase activity
molecular_function GO:0005515 protein binding
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 57..84
NoneNo IPR availableGENE3D2.60.120.620coord: 334..533
e-value: 4.6E-33
score: 114.2
IPR006620Prolyl 4-hydroxylase, alpha subunitSMARTSM00702p4hccoord: 342..526
e-value: 1.8E-52
score: 190.3
IPR013547Prolyl 4-hydroxylase alpha-subunit, N-terminalPFAMPF08336P4Ha_Ncoord: 42..173
e-value: 2.2E-26
score: 92.4
IPR005123Oxoglutarate/iron-dependent dioxygenasePFAMPF136402OG-FeII_Oxy_3coord: 422..526
e-value: 2.9E-14
score: 53.6
IPR005123Oxoglutarate/iron-dependent dioxygenasePROSITEPS51471FE2OG_OXYcoord: 418..527
score: 10.98
IPR011990Tetratricopeptide-like helical domainGENE3D1.25.40.10coord: 146..275
e-value: 7.8E-9
score: 35.0
IPR011990Tetratricopeptide-like helical domainSUPERFAMILY48452TPR-likecoord: 182..270

Blast
[Close]
BLAST of prolyl 4-hydroxylase vs. Swiss-Prot (Human)
Match: P4HA1 (Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens GN=P4HA1 PE=1 SV=2)

HSP 1 Score: 350.517 bits (898), Expect = 8.506e-115
Identity = 203/549 (36.98%), Postives = 319/549 (58.11%), Query Frame = 0 
Query:    9 IILQILFLVILLFETEAKSKSEEYQKPKHDFFTSASDMEVLLNVEKKLSKKFLRYVRKEEERLDKLEDEIRNIEDGWPQPGRSKAQWLSHVTNSYTILKRFSTFWPKIGDFSKSNTTKDHMLRLFSDLSRIKESLPAEEDMKGALNAVFRLQDTYDLPAADFIDGLGGDRAHK--LSVEEIFEIGFLCVGINDHYHAQQWLNEALNRFPVGIQQVGFLDRISLLEYLAWSEYHLGHLEQAVNLTAQIVHIDPTHKSAPINLELYQH------DLKASQFNPNIRKKVFRREK----DW---QTRHNNLCNGKEV-MEQEIIDKLYCEF-DNKRHPRFILKPLKVEHLYNEPGLTMYHDLLRDWEIDAVKEKARPLLKRATVHDPKTGELVFADYRISKSAWLKPEMDQIANHVINKVGDVINLDMRYSESLQVQNYGLAGQYEPHFDHSTVRTPKQFKELG-GNRIATMLLYMSEVERGGATIFVNTGPGVAIWPEKGAGVFWYNLLRNGDGDKKTRHAGCPVLVGHKWVSNLWIHEHGQEFRRQCSLN 539
            +I  IL + ILL ++ A             FFTS   M  L++ EK L      Y++ EE++L++++     ++       +    ++ H  N++ ++KR +T W ++ +       KD      S+L+  ++  P +ED  GA  A+ RLQDTY+L       G      HK  L+ E+ FE+G +     D+YH + W+ +AL +   G  ++  +D++S+L+YL+++ Y  G L++A+ LT +++ +DP H+ A  NL+ +++      D+  S  +    +K   ++K    D+   + ++  LC G+ + M      KL+C + D  R+P+FIL P K E  +++P +  +HD++ D EI+ VK+ A+P L+RAT+ +P TG+L    YRISKSAWL    + + + +  ++ D+  LD+  +E LQV NYG+ GQYEPHFD +    P  FKELG GNRIAT L YMS+V  GGAT+F     G ++WP+KG  VFWYNL  +G+GD  TRHA CPVLVG+KWVSN W+HE GQEFRR C+L+
Sbjct:    1 MIWYILIIGILLPQSLAHP----------GFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENL----VLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEG--EISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEV--GASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLS 531
The following BLAST results are available for this feature:
BLAST of prolyl 4-hydroxylase vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
P4HA18.506e-11536.98Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapie... [more]
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