Putative FGF receptor (polypeptide) - C. hemisphaerica

Overview
NamePutative FGF receptor
Unique NameTCONS_00041988-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length680

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00041988-protein ID=TCONS_00041988-protein|Name=Putative FGF receptor|organism=Clytia hemisphaerica|type=polypeptide|length=680bp
FTSFVYIFSDNKNDKTAPRVISQVTSLPEIVLNDVEVDCSIEGALPVNVS
WEKDGIPLSRVHRPGGFQYDNQRTILKLNKILPEDRGNYTCFIQNKYGST
SHSAEIEPLEKALTAPHFIGHNDAVIYGSIGESLNVTAQAVVFNTAHFQL
ILHHNHTNSTTNTTEQRLTVLSTPREIHLLGPETARESNDAYRYKLIFMF
KNLNASDFAIYSIMAGNTFGYDVYQFSIERRPAVKSPPVAEASTGKQTII
IVIISLAVGCIIILVVAALLWRHKSKRGFNNNNKFFSGTNIETVQLNLEP
TGRRIKYSSNRLSSCHTEKEYISDLVHYDEKWEVDYDNIELRGLLGEGAF
GRVMLSVVHGLPSNPNEPTVAAVKMLKDDATENELKDLLSEMQVMKNIGK
HINIVNLMGASTQQGKLCVIIEYCRYGNLRNYLKERRPTQPPNPPPIEQL
NLFHLTSFCLQVAKGLQYLASKKCIHRDIAARNVLVSENHVVKIADFGLA
RDVHQTDYYRKCTDGRLPVKWMAMEALFDRVYTIQSDIWSFGILAWEIVT
LGGSPYPGIPLERLFDLLKQGYRMERPVNCTEKMYELMLKCWSEQPLRRP
KYEDLIDDLEGQISEVSGIDYLDLQPPIIGYVHESVSSGRSASCSSENSA
PVFETEDDSPNQTRRQQEQAKLLSDRSDGT
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_025877XLOC_025877Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00041988TCONS_00041988Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR003598Ig_sub2
IPR020635Tyr_kinase_cat_dom
IPR013783Ig-like_fold
IPR013098Ig_I-set
IPR008266Tyr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR000719Prot_kinase_dom
IPR007110Ig-like_dom
IPR011009Kinase-like_dom
Vocabulary: Molecular Function
TermDefinition
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0005524ATP binding
Vocabulary: Biological Process
TermDefinition
GO:0006468protein phosphorylation
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006468 protein phosphorylation
molecular_function GO:0005524 ATP binding
molecular_function GO:0004672 protein kinase activity
molecular_function GO:0004713 protein tyrosine kinase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPRINTSPR00109TYRKINASEcoord: 421..434
score: 41.14
coord: 468..486
score: 64.01
coord: 517..527
score: 61.26
coord: 536..558
score: 63.08
coord: 580..602
score: 40.25
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPFAMPF07714Pkinase_Tyrcoord: 340..609
e-value: 1.6E-95
score: 319.2
IPR003598Immunoglobulin subtype 2SMARTSM00408igc2_5coord: 30..98
e-value: 9.8E-11
score: 51.7
IPR020635Tyrosine-protein kinase, catalytic domainSMARTSM00219tyrkin_6coord: 339..609
e-value: 2.2E-132
score: 455.8
NoneNo IPR availablePIRSFPIRSF000615TyrPK_CSF1-Rcoord: 1..260
e-value: 3.7E-4
score: 16.7
coord: 321..441
e-value: 8.1E-36
score: 121.4
coord: 443..678
e-value: 6.1E-76
score: 254.3
coord: 215..279
e-value: 35.0
score: 0.1
NoneNo IPR availableGENE3D3.30.200.20coord: 321..423
e-value: 4.5E-20
score: 71.0
NoneNo IPR availableGENE3D1.10.510.10coord: 424..678
e-value: 1.4E-49
score: 168.1
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 640..680
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 113..232
e-value: 0.36
score: 10.4
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 9..112
e-value: 9.3E-14
score: 50.7
IPR013098Immunoglobulin I-setPFAMPF07679I-setcoord: 34..106
e-value: 3.5E-10
score: 39.7
IPR008266Tyrosine-protein kinase, active sitePROSITEPS00109PROTEIN_KINASE_TYRcoord: 474..486
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 345..374
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 339..622
score: 39.679
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 18..107
score: 11.315
IPR007110Immunoglobulin-like domainSUPERFAMILY48726Immunoglobulincoord: 16..110
IPR011009Protein kinase-like domainSUPERFAMILY56112Protein kinase-like (PK-like)coord: 309..609

Blast
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BLAST of Putative FGF receptor vs. Swiss-Prot (Human)
Match: FGFR2 (Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1)

HSP 1 Score: 427.943 bits (1099), Expect = 2.170e-139
Identity = 255/673 (37.89%), Postives = 366/673 (54.38%), Query Frame = 0 
Query:    9 SDNKNDKTAP------RVISQVTSLPEIVLNDVEVDCSIEGALPVNVSWEKDGIPLSRVHRPGGFQYDNQRTILKLNKILPEDRGNYTCFIQNKYGSTSHSAEIEPLEKALTAPHFIGHNDAVIYGSIGESLNVTAQAVVFNTAHFQLILHHNHTNSTTNTTEQRLTVLSTPREIHLLGPETARESNDAYRYKLIFMFKNLNASDFAIYSIMAGNTFGYDVYQFSIERRPAVKSPPVAEASTGKQTIIIVIISLAVGCIIILVVAALLWRHKSKRGFNNNNKFFSGTNIETVQLNLEPTGRRIKYS----------------SNRLSSCHTEKEYISDLVHY----DEKWEVDYDNIELRGLLGEGAFGRVMLSVVHGLPSN-PNEPTVAAVKMLKDDATENELKDLLSEMQVMKNIGKHINIVNLMGASTQQGKLCVIIEYCRYGNLRNYLKERRP-----TQPPNPPPIEQLNLFHLTSFCLQVAKGLQYLASKKCIHRDIAARNVLVSENHVVKIADFGLARDVHQTDYYRKCTDGRLPVKWMAMEALFDRVYTIQSDIWSFGILAWEIVTLGGSPYPGIPLERLFDLLKQGYRMERPVNCTEKMYELMLKCWSEQPLRRPKYEDLIDDLEGQISEVSGIDYLDLQPPIIGYVHESVSSGRSASCSSENS 649
            S+N N+K AP      ++  ++ ++P    N V+  C   G     + W K+G    + HR GG++  NQ   L +  ++P D+GNYTC ++N+YGS +H+  ++ +E++   P       A     +G  +    +       H Q I H     S              P  +  L    A   N   +   +   +N+   D   Y+ +AGN+ G   +   +   PA       E +     + I I  + V  I  +VV  +L R K+         F S   +  +   + P  R++  S                + RLSS   +   ++ +  Y    D KWE   D + L   LGEG FG+V+++   G+  + P E    AVKMLKDDATE +L DL+SEM++MK IGKH NI+NL+GA TQ G L VI+EY   GNLR YL+ RRP     +   N  P EQ+    L S   Q+A+G++YLAS+KCIHRD+AARNVLV+EN+V+KIADFGLARD++  DYY+K T+GRLPVKWMA EALFDRVYT QSD+WSFG+L WEI TLGGSPYPGIP+E LF LLK+G+RM++P NCT ++Y +M  CW   P +RP ++ L++DL+  ++  +  +YLDL  P+  Y   S    RS+  S ++S
Sbjct:  145 SENSNNKRAPYWTNTEKMEKRLHAVP--AANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG-----------PDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGRE--KEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNT---TKKPDFSSQPAVHKLTKRI-PLRRQVTVSAESSSSMNSNTPLVRITTRLSST-ADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQY-SPSYPDTRSSCSSGDDS 796
The following BLAST results are available for this feature:
BLAST of Putative FGF receptor vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
FGFR22.170e-13937.89Fibroblast growth factor receptor 2 OS=Homo sapien... [more]
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