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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00020632-protein ID=TCONS_00020632-protein|Name=TCONS_00020632-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1111bp
MFTFGFGQKKFKMAAASLDDEGRGHEGFKSFFSKISESLSSAVASTTRTV
VDKRTFDKAWKSLDKVSRFCQNTKLNLKNSPPFMLDILPDTHQHLKLILQ
HYEEKLHILNECEYFKIYVDNLERKCKQVIRLFKDSGQRIFDEKDNSRRK
LTKLSLIFSHMLTDLKAIFPNGVYIGSNFKITKSDAAEFWNQSFGTSRTI
VPWKMFREHLQFVHPIGSNLEAIALKTTLDFVVNEHISIFEFDVFTRLFT
PWSTIISNWNLLAVTHPGYMAFLTYDEVKETLNRYISKPGSYIFRLSCTR
LGQWAIGYVTQEGAILQTIPQHKTLMQALVDGARDGIYLFPNGKEQNPDL
SPYLVETKQQHIQVTCEQYEIYVEMGSTFQLCKICAENDKDTKIEPCGHL
MCQACLRHWQDTGGTGCPFCRSDIKGIENIVIDPFNKKSTEEKKANVSTP
STPAELMKAPFSGHTSNDHLQRKISPPNGARPAEKLPPRNFQKSEPQNFT
RPQGPHPSTTQQQQHAPQEQQTSNNAYDTSRKNEIAETILLSGSLNPINS
VNSRQLSPPVILSPPPLPSRQPTMEGIWHSQSPRWTPTSSPKASPFNSPR
ASPCHTPGGSPSTTRRQSPDDLPPIPKPYNGNSSLLRHTPVDNAPPFSDM
DQNNELPPLPARNKRPNRPPPRNTASPIPNQIERKTSGSLKETARFQVHK
SSLHRRTRSDDQLDKSYDEGDFEEVPPLQRSLSVTKNKCYEPIFNSSSAF
LLPQISGKDDKSNSIESLEHYDSKSTKPIPNRSKLDPNRPVPLPPGPNGV
ENKVQRPNTLSVIPGSRPGSTSDSDAPTPTLPPKKNKIGGLVTPDYGLDC
HKSDIVELDEKVELSPFDDEKTKLVEDMLKVNLLDDAKENKDGDKPPNRK
QSDVYYPIESNNFVSGDIVSCHDFDNDDDSDSDAVDDYDAPVPVIHTPTV
EVAAAKWSPVSSDEASTPSSEFAKYIGTKDPFSDDEFFNRKGDVTEAPAS
SPPPPALPQRSTDYPKKSAETRKSHESIDSSASLMDLHHNQNHTGASSTL
PPLPSGRTGGRPDTSMKHYEEDYAILMSQGYSREDIRKALKVADNNFAIA
RNILKEFSHNK Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Cellular Component
| Term | Definition |
|---|
| GO:0005634 | nucleus |
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0004871 | signal transducer activity |
| GO:0005509 | calcium ion binding |
| GO:0001784 | phosphotyrosine binding |
| GO:0005515 | protein binding |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0007166 | cell surface receptor signaling pathway |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0007166 |
cell surface receptor signaling pathway |
| cellular_component |
GO:0005634 |
nucleus |
| molecular_function |
GO:0005509 |
calcium ion binding |
| molecular_function |
GO:0001784 |
phosphotyrosine binding |
| molecular_function |
GO:0005515 |
protein binding |
| molecular_function |
GO:0004871 |
signal transducer activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| IPR001841 | Zinc finger, RING-type | SMART | SM00184 | ring_2 | coord: 382..420
e-value: 3.5E-7
score: 39.9 |
| IPR001841 | Zinc finger, RING-type | PROSITE | PS50089 | ZF_RING_2 | coord: 382..421
score: 12.607 |
| IPR001841 | Zinc finger, RING-type | CDD | cd00162 | RING | coord: 382..424
e-value: 2.28903E-11
score: 59.7668 |
| IPR015940 | Ubiquitin-associated domain | SMART | SM00165 | uba_6 | coord: 1069..1106
e-value: 0.0029
score: 26.9 |
| IPR015940 | Ubiquitin-associated domain | PFAM | PF00627 | UBA | coord: 1069..1104
e-value: 2.6E-5
score: 23.9 |
| IPR015940 | Ubiquitin-associated domain | PROSITE | PS50030 | UBA | coord: 1067..1107
score: 8.956 |
| IPR003153 | Adaptor protein Cbl, N-terminal helical | PFAM | PF02262 | Cbl_N | coord: 51..174
e-value: 3.4E-50
score: 169.1 |
| IPR003153 | Adaptor protein Cbl, N-terminal helical | GENE3D | 1.20.930.20 | | coord: 50..174
e-value: 4.3E-53
score: 178.1 |
| IPR003153 | Adaptor protein Cbl, N-terminal helical | SUPERFAMILY | 47668 | N-terminal domain of cbl (N-cbl) | coord: 49..176 |
| IPR000980 | SH2 domain | GENE3D | 3.30.505.10 | | coord: 266..351
e-value: 1.6E-45
score: 152.2 |
| IPR000980 | SH2 domain | SUPERFAMILY | 55550 | SH2 domain | coord: 265..351 |
| None | No IPR available | PFAM | PF14447 | Prok-RING_4 | coord: 382..425
e-value: 1.7E-12
score: 46.9 |
| None | No IPR available | GENE3D | 1.10.8.10 | | coord: 1062..1108
e-value: 2.3E-5
score: 23.7 |
| None | No IPR available | GENE3D | 1.10.238.10 | | coord: 176..264
e-value: 1.1E-35
score: 121.7 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 921..942 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 750..842 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 439..528 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 554..734 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 954..1065 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 883..904 |
| None | No IPR available | SUPERFAMILY | 57850 | RING/U-box | coord: 359..435 |
| IPR014741 | Adaptor protein Cbl, EF hand-like | PFAM | PF02761 | Cbl_N2 | coord: 179..263
e-value: 1.6E-32
score: 111.9 |
| IPR014742 | Adaptor protein Cbl, SH2-like domain | PFAM | PF02762 | Cbl_N3 | coord: 265..350
e-value: 5.3E-44
score: 147.9 |
| IPR014742 | Adaptor protein Cbl, SH2-like domain | CDD | cd09920 | SH2_Cbl-b_TKB | coord: 258..353
e-value: 4.36404E-56
score: 189.184 |
| IPR013083 | Zinc finger, RING/FYVE/PHD-type | GENE3D | 3.30.40.10 | | coord: 364..539
e-value: 4.9E-11
score: 42.1 |
| IPR017907 | Zinc finger, RING-type, conserved site | PROSITE | PS00518 | ZF_RING_1 | coord: 397..406 |
| IPR024159 | Adaptor protein Cbl, PTB domain | PROSITE | PS51506 | CBL_PTB | coord: 45..352
score: 95.83 |
| IPR011992 | EF-hand domain pair | SUPERFAMILY | 47473 | EF-hand | coord: 179..264 |
| IPR009060 | UBA-like | SUPERFAMILY | 46934 | UBA-like | coord: 1065..1106 |
Blast
BLAST of TCONS_00020632-protein vs. Swiss-Prot (Human)
Match: CBLB (E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens GN=CBLB PE=1 SV=2) HSP 1 Score: 569.696 bits (1467), Expect = 0.000e+0 Identity = 258/418 (61.72%), Postives = 324/418 (77.51%), Query Frame = 0
Query: 35 ISESLSSAVASTTRTVVDKRTFDKAWKSLDKVSRFCQNTKLNLKNSPPFMLDILPDTHQHLKLILQHYE--EKLHILNECEYFKIYVDNLERKCKQVIRLFKDSGQRIFDEKDNSRRKLTKLSLIFSHMLTDLKAIFPNGVYIGSNFKITKSDAAEFWNQSFGTSRTIVPWKMFREHLQFVHPIGSNLEAIALKTTLDFVVNEHISIFEFDVFTRLFTPWSTIISNWNLLAVTHPGYMAFLTYDEVKETLNRYISKPGSYIFRLSCTRLGQWAIGYVTQEGAILQTIPQHKTLMQALVDGARDGIYLFPNGKEQNPDLSPYLVETKQQHIQVTCEQYEIYVEMGSTFQLCKICAENDKDTKIEPCGHLMCQACLRHWQDTGGTGCPFCRSDIKGIENIVIDPFNKKSTEEKKANVSTP 450
I +++ AV + D+RT +K WK +DKV R CQN KL LKNSPP++LDILPDT+QHL+LIL Y+ +KL L+E EYFKIY+D+L +K K+ IRLFK+ +R+++E+ RR LTKLSLIFSHML ++KAIFPNG + G NF+ITK+DAAEFW + FG +TIVPWK+FR+ L VH I S LEA+ALK+T+D N++IS+FEFD+FTRLF PW +I+ NWN LAVTHPGYMAFLTYDEVK L +Y +KPGSYIFRLSCTRLGQWAIGYVT +G ILQTIP +K L QAL+DG+R+G YL+P+G+ NPDL+ T HI+VT EQYE+Y EMGSTFQLCKICAENDKD KIEPCGHLMC +CL WQ++ G GCPFCR +IKG E I++DPF+ + + ++ P
Sbjct: 25 IIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFG-DKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDP 441
The following BLAST results are available for this feature:
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