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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00067023-protein ID=TCONS_00067023-protein|Name=Putative tyrosine kinase receptor protein|organism=Clytia hemisphaerica|type=polypeptide|length=989bp
LDIIYILQLTMNGFHRHTALSLYLLCLKLFQLVVANTQADRATLYFASGK
AFDLPCRNETGGRFATVFWYTDAYTNDNRIRTDVYTYEEGKETIHSEYFE
NRLQRIKGTSLRIKDSKLTDSGKWTCDIVYEETTGGKTGLKVKTMAAYDV
HIVGQPSVIDLSINGLLLKKGESTNVKIPFCESQALSDFNITWTKLSGTM
SSNVKIGTSKPKKIPGPGPLTTYIRRVTLTFTNFSEQDVGQYQCMAKNIG
GELTKVMAARMRKPPLIFSRRVFNIDVGVVNGFLECKAKGYPSMDFTWRV
YPDTPKSNLMHPTEHIDDFKISKTVYDSVSEIGSSRLTISKIKKSHHGKY
ICIASTNDLESTQLEIQLEGKAPPDTPVIIQENTKIEENEVTLFWKVLDD
GGSAVTSVKIDYKNSSTLKDWSSVEVYDRQADSYTIQNLVKGTSYDFRIR
ASNIKGDSDYSEIFTLTTIGLDNGVPTSEPTTDDQILGNLDMTTMIGIFG
GVFIALVVGFICVCIFVRKMQKGEKEDTAPPQQSFASFAPSTTPGTQQRS
MVDGHAAAMEMQPLMMRQPDEWEFPRDRLTITTVLGAGAFGVVMRGLAQG
IKGSVGQITVAVKTVRDTTNEAATKDLIAELNLLKLIPEHQNVVGLLGCC
TYADPLYVIVEYCSNGDLQGFLRSSRGIYERYYRTSYGGAVPNLTSKMLL
TFAWQVAKGMNHLSSMKVIHRDLAARNVLVDDQLVCKVSDFGFARDIYVE
DHYLKRSAGGRFPIKWMAIESLLDGISTTKSDVWSFGVVFWELITLGASP
YPGMNSYEVVSFLQDGYRMDKPKHCADEIYQLMMDCWCVAPGRRPSFVDL
INKCQLLMDEADNKELINMNFYPDHLYVNFDGSNSSAVSTATTPHGTLTR
NHINSVNNKPSNMVDNHSGGGTLGSNHHVQQTPRSKLRSPSNHSMPSGRT
NSVPALSERSLTGASNHSFHANQHPSERVGLLSQMSQPS Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0004672 | protein kinase activity |
| GO:0005515 | protein binding |
| GO:0004713 | protein tyrosine kinase activity |
| GO:0005524 | ATP binding |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0006468 | protein phosphorylation |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0006468 |
protein phosphorylation |
| molecular_function |
GO:0005524 |
ATP binding |
| molecular_function |
GO:0005515 |
protein binding |
| molecular_function |
GO:0004672 |
protein kinase activity |
| molecular_function |
GO:0004713 |
protein tyrosine kinase activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | PRINTS | PR00109 | TYRKINASE | coord: 825..847
score: 43.96
coord: 762..772
score: 58.83
coord: 712..730
score: 62.62
coord: 660..673
score: 47.84
coord: 781..803
score: 63.23 |
| IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | PFAM | PF07714 | Pkinase_Tyr | coord: 580..852
e-value: 3.0E-91
score: 305.2 |
| IPR003599 | Immunoglobulin subtype | SMART | SM00409 | IG_3c | coord: 41..143
e-value: 2.3
score: 17.0
coord: 274..367
e-value: 0.65
score: 19.0
coord: 163..257
e-value: 29.0
score: 7.4 |
| IPR003961 | Fibronectin type III | SMART | SM00060 | FN3_2 | coord: 374..458
e-value: 3.9E-7
score: 39.7 |
| IPR003961 | Fibronectin type III | PFAM | PF00041 | fn3 | coord: 385..461
e-value: 4.0E-9
score: 36.6 |
| IPR003961 | Fibronectin type III | PROSITE | PS50853 | FN3 | coord: 373..471
score: 21.254 |
| IPR003961 | Fibronectin type III | CDD | cd00063 | FN3 | coord: 373..468
e-value: 1.08107E-14
score: 70.6031 |
| IPR003961 | Fibronectin type III | SUPERFAMILY | 49265 | Fibronectin type III | coord: 368..476 |
| IPR020635 | Tyrosine-protein kinase, catalytic domain | SMART | SM00219 | tyrkin_6 | coord: 579..857
e-value: 1.4E-124
score: 429.8 |
| IPR003598 | Immunoglobulin subtype 2 | SMART | SM00408 | igc2_5 | coord: 47..133
e-value: 3.2
score: 2.3
coord: 171..251
e-value: 0.0041
score: 26.4
coord: 283..359
e-value: 0.22
score: 13.3 |
| IPR013783 | Immunoglobulin-like fold | GENE3D | 2.60.40.10 | | coord: 236..292
e-value: 0.052
score: 13.2 |
| IPR013783 | Immunoglobulin-like fold | GENE3D | 2.60.40.10 | | coord: 158..235
e-value: 3.5E-4
score: 20.4 |
| IPR013783 | Immunoglobulin-like fold | GENE3D | 2.60.40.10 | | coord: 371..469
e-value: 1.0E-19
score: 70.3 |
| IPR013783 | Immunoglobulin-like fold | GENE3D | 2.60.40.10 | | coord: 32..157
e-value: 2.7E-8
score: 33.2 |
| IPR013783 | Immunoglobulin-like fold | GENE3D | 2.60.40.10 | | coord: 293..370
e-value: 2.2E-9
score: 36.8 |
| None | No IPR available | GENE3D | 1.10.510.10 | | coord: 662..915
e-value: 1.2E-48
score: 164.7 |
| None | No IPR available | GENE3D | 3.30.200.20 | | coord: 561..661
e-value: 3.2E-20
score: 71.5 |
| None | No IPR available | PFAM | PF13927 | Ig_3 | coord: 284..355
e-value: 1.5E-7
score: 31.8 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 526..549 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 888..989 |
| None | No IPR available | CDD | cd00096 | Ig | coord: 181..255
e-value: 4.238E-5
score: 41.7059 |
| None | No IPR available | CDD | cd00096 | Ig | coord: 284..367
e-value: 3.06086E-7
score: 48.2543 |
| None | No IPR available | CDD | cd00192 | PTKc | coord: 584..853
e-value: 4.91188E-125
score: 381.887 |
| IPR008266 | Tyrosine-protein kinase, active site | PROSITE | PS00109 | PROTEIN_KINASE_TYR | coord: 718..730 |
| IPR017441 | Protein kinase, ATP binding site | PROSITE | PS00107 | PROTEIN_KINASE_ATP | coord: 585..613 |
| IPR007110 | Immunoglobulin-like domain | PROSITE | PS50835 | IG_LIKE | coord: 156..262
score: 8.847 |
| IPR007110 | Immunoglobulin-like domain | PROSITE | PS50835 | IG_LIKE | coord: 264..367
score: 9.482 |
| IPR007110 | Immunoglobulin-like domain | PROSITE | PS50835 | IG_LIKE | coord: 49..143
score: 7.159 |
| IPR007110 | Immunoglobulin-like domain | SUPERFAMILY | 48726 | Immunoglobulin | coord: 181..254 |
| IPR007110 | Immunoglobulin-like domain | SUPERFAMILY | 48726 | Immunoglobulin | coord: 45..129 |
| IPR007110 | Immunoglobulin-like domain | SUPERFAMILY | 48726 | Immunoglobulin | coord: 283..379 |
| IPR000719 | Protein kinase domain | PROSITE | PS50011 | PROTEIN_KINASE_DOM | coord: 579..858
score: 39.043 |
| IPR011009 | Protein kinase-like domain | SUPERFAMILY | 56112 | Protein kinase-like (PK-like) | coord: 559..852 |
Blast
BLAST of Putative tyrosine kinase receptor protein vs. Swiss-Prot (Human)
Match: FGFR1 (Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3) HSP 1 Score: 294.278 bits (752), Expect = 5.365e-86 Identity = 174/493 (35.29%), Postives = 267/493 (54.16%), Query Frame = 0
Query: 422 SSVEVYDRQADSYTIQNLVKGTSYDFRIRASNIKGDSDYSEIFTLTTIGLDNGVPTSEPTTDDQILGNLDMTTMIGIFGGVFIALVVGFICVCIFVRKMQKGEKEDTAPPQQSFASFAPSTTPGTQQRSMVDGHAAAMEMQPLMMRQ-------------------PDE--WEFPRDRLTITTVLGAGAFGVVMRGLAQGI-KGSVGQIT-VAVKTVRDTTNEAATKDLIAELNLLKLIPEHQNVVGLLGCCTYADPLYVIVEYCSNGDLQGFLRSSRGIYERYYRTSYGGAVPNLTSKMLLTFAWQVAKGMNHLSSMKVIHRDLAARNVLVDDQLVCKVSDFGFARDIYVEDHYLKRSAGGRFPIKWMAIESLLDGISTTKSDVWSFGVVFWELITLGASPYPGMNSYEVVSFLQDGYRMDKPKHCADEIYQLMMDCWCVAPGRRPSFVDLINKCQLLMDEADNKELINMNFYPDHLYVNFDGSNSSAVSTA 891
+ V D++ + ++N+ + ++ A N G S +S T+ + + P L + +I G I+ +VG + V KM+ G K+ Q + A S P +Q ++ +A+M L++R P++ WE PRDRL + LG G FG V+ A G+ K ++T VAVK ++ E DLI+E+ ++K+I +H+N++ LLG CT PLYVIVEY S G+L+ +L++ R Y L+SK L++ A+QVA+GM +L+S K IHRDLAARNVLV + V K++DFG ARDI+ D+Y K++ GR P+KWMA E+L D I T +SDVWSFGV+ WE+ TLG SPYPG+ E+ L++G+RMDKP +C +E+Y +M DCW P +RP+F L+ ++ N+E ++++ D +F + SS S+
Sbjct: 314 AGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSP---------LYLEIIIYCTGAFLISCMVG----SVIVYKMKSGTKKSDFHSQMAVHKLAKSI-PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY-KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSG 791
The following BLAST results are available for this feature:
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