Incomplete threonine/tyrosine kinase protein (polypeptide) - C. hemisphaerica

Overview
NameIncomplete threonine/tyrosine kinase protein
Unique NameTCONS_00052593-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1309

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00052593-protein ID=TCONS_00052593-protein|Name=Incomplete threonine/tyrosine kinase protein|organism=Clytia hemisphaerica|type=polypeptide|length=1309bp
MSHPAKAITFYRKNTDDKLSKLVIDGSKYQLLNLQELVIYNVQNSDDAVY
VCRPENDVLQDKEIKLFINQFAQDAPFAKVEPTYLDLDFNAADNVTCTTY
GNNVAGEWLRTKQVNGQTELEKVPTEKIQGRFQLTPQGLYQREWTLMFKD
VTEADAGSYICKVTADTKPTFREVDVAVKPAQAPQIRKFPAQVTKENVRT
SLNCRSNGAPKPKIQFFKDGVEITSGSNGYVIDGRKLHIEKPKFPEHDGV
YTCSVTNMFGKATKKSSLTVTVAPIIEKKQSIVVVGSEDKLKIACNITRS
NPVPNITWQYQPWPCQESKGYNCDPISTRWQTADPAKLDIKPRTPNTMYS
VFKVPTSNVKRFFVRCTAKHKYGQDTHQVIGIIDKRNAENLLRSSPSFET
NEREPFKLECTGGAGLFLNLTWKKDDKEIQLTDRMTLRKTGSILENQQIV
LSVGNSTPADSGFYKCIGVPARPEDGLVIVGTQVVINKIYAPRLTSLKQA
EVRNDENAIITCYVDSHPTAAVTWFKEGKQLVVETIDSIDECSNRDEGKY
FELVDNSKNTKPKRHRLVICKSQWKINNGTYSCEAKNNLGMARQQTTVLV
FAPPKIVYAQFDEYPSPEKSYSRNCTTEGNPLPIVWWEKEINGNFVLFSS
NYTTGVSFLNITKFEGKHYGTYRCVASNVIDEVVDTMTLKKPVLVLGGYG
SNNGIAQTASLVAALVVAVLIIIILVVLAVILYKRKRLYGGFYILSIPPS
PDYFKKLDPTRPLSDQTNKLPYFPEWEYPRNKIKLKNCVGAGAFGEVYIA
DAIGICAFDPRYKIGAKHKPLLYKKRFSFTKSKLARQDSVASTRSSRSTK
SLLSKSGDRNAVVAVKKLKENASTVEYKDLIAELKILIHIGQNKHIVNLL
GACTKGIEMDSMVILEFCPHGNLLSFVKSRRQIFKPVWSKQHLGMEKEFT
LFDLCVAGYQVAKGLEFLADRKCVHRDVAARNVLVGENYVMKIADFGLAR
DVYEDERYVKVSGGLLPIKWMALESIVDRVFTHASDVWSFGVLMWEVMTL
GGGPYPGIAARELPEFLSSGGRMEQPPRCPNEVFQLMLETWNELPDHRPT
FNDIVMRLASVVEAHCNPQDIPHYLDKEHVSGNNSDYLRPVDSDVGSYKI
NSSSSYASSLGRNDDVFRRHDSSTQSERYVPDNRFNDNEVSERLLGDFSN
KDVNDGASDKSIEAKPKMDEMVSEKDYKKVNGKQNGYENDTGSLKKKNKK
NKQKSKETKLEMEENEKDINEKDGLLNGGDRTPSEVEEFSSFIDGEYEKM
DNNEGYING
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_033251XLOC_033251Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00052593TCONS_00052593Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR020635Tyr_kinase_cat_dom
IPR003598Ig_sub2
IPR003599Ig_sub
IPR013783Ig-like_fold
IPR013098Ig_I-set
IPR008266Tyr_kinase_AS
IPR007110Ig-like_dom
IPR000719Prot_kinase_dom
IPR011009Kinase-like_dom
Vocabulary: Molecular Function
TermDefinition
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0005524ATP binding
Vocabulary: Biological Process
TermDefinition
GO:0006468protein phosphorylation
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006468 protein phosphorylation
molecular_function GO:0005524 ATP binding
molecular_function GO:0004672 protein kinase activity
molecular_function GO:0004713 protein tyrosine kinase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 1245..1272
NoneNo IPR availablePFAMPF13927Ig_3coord: 184..257
e-value: 1.7E-9
score: 38.0
NoneNo IPR availableGENE3D3.30.200.20coord: 764..914
e-value: 1.2E-16
score: 60.0
NoneNo IPR availableGENE3D1.10.510.10coord: 915..1274
e-value: 1.6E-42
score: 144.6
NoneNo IPR availablePIRSFPIRSF000615TyrPK_CSF1-Rcoord: 938..1268
e-value: 8.2E-67
score: 224.0
coord: 3..395
e-value: 1.1E-12
score: 44.9
coord: 393..820
e-value: 3.6E-24
score: 82.9
coord: 848..949
e-value: 8.7E-21
score: 71.7
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1153..1285
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1290..1309
NoneNo IPR availableCDDcd00096Igcoord: 508..597
e-value: 2.76853E-7
score: 48.6395
NoneNo IPR availableCDDcd00096Igcoord: 624..688
e-value: 4.05383E-6
score: 45.1727
NoneNo IPR availableCDDcd00096Igcoord: 94..164
e-value: 0.00180433
score: 37.0835
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPRINTSPR00109TYRKINASEcoord: 1016..1026
score: 58.23
coord: 1079..1101
score: 43.36
coord: 967..985
score: 56.9
coord: 1035..1057
score: 66.44
coord: 915..928
score: 37.16
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPFAMPF07714Pkinase_Tyrcoord: 855..1108
e-value: 8.6E-81
score: 270.9
IPR020635Tyrosine-protein kinase, catalytic domainSMARTSM00219tyrkin_6coord: 783..1108
e-value: 3.6E-114
score: 395.3
IPR003598Immunoglobulin subtype 2SMARTSM00408igc2_5coord: 616..681
e-value: 0.19
score: 13.9
coord: 195..260
e-value: 1.1E-5
score: 34.9
coord: 503..590
e-value: 2.9E-4
score: 30.2
coord: 401..473
e-value: 4.6
score: 0.8
IPR003599Immunoglobulin subtypeSMARTSM00409IG_3ccoord: 84..179
e-value: 6.6
score: 13.0
coord: 395..487
e-value: 0.041
score: 23.0
coord: 189..271
e-value: 1.8
score: 17.5
coord: 617..692
e-value: 58.0
score: 4.8
coord: 497..601
e-value: 0.0016
score: 27.7
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 631..692
e-value: 1.9E-6
score: 27.5
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 272..387
e-value: 3.6E-5
score: 23.2
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 493..630
e-value: 4.3E-16
score: 58.6
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 1..69
e-value: 1.1E-4
score: 21.8
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 79..194
e-value: 9.3E-10
score: 38.1
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 388..470
e-value: 1.2E-7
score: 31.3
IPR013783Immunoglobulin-like foldGENE3D2.60.40.10coord: 195..271
e-value: 1.2E-16
score: 60.2
IPR013098Immunoglobulin I-setPFAMPF07679I-setcoord: 496..599
e-value: 1.1E-7
score: 31.7
IPR008266Tyrosine-protein kinase, active sitePROSITEPS00109PROTEIN_KINASE_TYRcoord: 973..985
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 389..466
score: 7.268
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 76..177
score: 8.593
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 184..271
score: 10.48
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 604..690
score: 9.083
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 492..599
score: 11.533
IPR007110Immunoglobulin-like domainSUPERFAMILY48726Immunoglobulincoord: 600..689
IPR007110Immunoglobulin-like domainSUPERFAMILY48726Immunoglobulincoord: 95..180
IPR007110Immunoglobulin-like domainSUPERFAMILY48726Immunoglobulincoord: 181..275
IPR007110Immunoglobulin-like domainSUPERFAMILY48726Immunoglobulincoord: 268..323
coord: 410..467
IPR007110Immunoglobulin-like domainSUPERFAMILY48726Immunoglobulincoord: 495..607
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 783..1112
score: 34.577
IPR011009Protein kinase-like domainSUPERFAMILY56112Protein kinase-like (PK-like)coord: 857..1106
coord: 761..807

Blast
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BLAST of Incomplete threonine/tyrosine kinase protein vs. Swiss-Prot (Human)
Match: VGFR2 (Vascular endothelial growth factor receptor 2 OS=Homo sapiens GN=KDR PE=1 SV=2)

HSP 1 Score: 295.434 bits (755), Expect = 4.492e-82
Identity = 236/731 (32.28%), Postives = 339/731 (46.37%), Query Frame = 0 
Query:  461 SGFYKCIGVPARPEDGLVIVGTQVV-INKIYAPRLTSLKQAEVRNDENAIITCYVDSHPTAAVTWFKEGKQLVVETIDSIDE--CSNRDEGKYFELVDNSKNTKPKRHRLVICKSQWKINNGTYSCEAKNNLGMAR----QQTTVLVFAPPKIVYAQFDEYPSPEKSYSRNCTTEGNPLPIVWWEKEINGNFVLFSS-NYTTGVSFLNITKFEGKHYGTYRCVASNVIDEVVDTMTLKKPVLVLGGYGSNNGIAQTASLVAALVVAVLIIIILVVLAVILYKRKRLYGGFY---ILSIPPSPDYFKKLDPTRPLSDQTNKLPY-FPEWEYPRNKIKLKNCVGAGAFGEVYIADAIGICAFDPRYKIGAKHKPLLYKKRFSFTKSKLARQDSVASTRSSRSTKSLLSKSGDRNAVVAVKKLKENASTVEYKDLIAELKILIHIGQNKHIVNLLGACTK-GIEMDSMVILEFCPHGNLLSFVKSRRQIFKPVWSK--------QHLG-----------------------------------------MEKEF-TLFDLCVAGYQVAKGLEFLADRKCVHRDVAARNVLVGENYVMKIADFGLARDVYEDERYVKVSGGLLPIKWMALESIVDRVFTHASDVWSFGVLMWEVMTLGGGPYPGIAARELPEF---LSSGGRMEQPPRCPNEVFQLMLETWNELPDHRPTFNDIVMRLASVVEAHCNPQDIPHYL 1125
            S  YKC  V        V  G +V+  +    P +T     +    E+  + C  D      +TW+K G Q +   +  +    C N D    ++L     +       ++  K+    + G Y C A++     R    +Q TVL    P I     ++  S  +S   +CT  GNP P + W K+ N   V  S      G   L I +   +  G Y C A +V+        ++   ++ G     N   +   LV   V+A+   ++LV+   IL   KR  GG      LSI   PD         PL +   +LPY   +WE+PR+++KL   +G GAFG+V  ADA GI                                D  A+ R+                 VAVK LKE A+  E++ L++ELKILIHIG + ++VNLLGACTK G  +  MVI+EFC  GNL ++++S+R  F P  +K         ++G                                         + K+F TL  L    +QVAKG+EFLA RKC+HRD+AARN+L+ E  V+KI DFGLARD+Y+D  YV+     LP+KWMA E+I DRV+T  SDVWSFGVL+WE+ +LG  PYPG+   E  EF   L  G RM  P     E++Q ML+ W+  P  RPTF+++V  L ++++A+   QD   Y+
Sbjct:  525 SALYKCEAV------NKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLD--TLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKD-NETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLG----CAKVEAFFIIEGAQEKTN--LEIIILVGTAVIAMFFWLLLVI---ILRTVKRANGGELKTGYLSIVMDPDEL-------PLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGI--------------------------------DKTATCRT-----------------VAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPL--MVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE--EFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQ-QDGKDYI 1176

HSP 2 Score: 83.1889 bits (204), Expect = 7.032e-16
Identity = 122/504 (24.21%), Postives = 195/504 (38.69%), Query Frame = 0 
Query:  145 TLMFKDVTEADAGSYICKVTAD--TKPTFREVDVAVKP--AQAPQIRKFPAQVTKENVRTSLNCRSNGAPKPKIQFFKDGVEITSGSNGYVIDGRKLHIEKPKFPEHD-GVYTCSVTNMFGKATKKS--SLTVTVAPIIEKKQSIVVVGSED---KLKIACNITRSNPVPNITWQYQ-----------------PWPCQESKGYNCDPISTRWQTADPAKLDIKPRTPNTMYSVFKVPTSNVKRFFVRCTAKHKYGQDTHQVIGIIDKRNAENLLRSSPSFETNEREPFKLECTGGAGLFLNLTW--------------------KKDDKEIQLTDRMTLRKTGSILENQQIVLSVGNSTPADSGFYKCIGVPARPEDGLVIVGTQVVINKIYAPRLT-SLKQAEVRNDENAIITCYVDSHPTAAVTWFKEGKQLVVETIDSIDECSNRDEGKYFELVDNSKNTKPKRHRLVICKSQWKINNGTYSCEAKNNLGMARQQTTVLV 600
            TL    VT +D G Y C  ++   TK     V V  KP  A    +         E VR  +  +  G P P+I+++K+G+ + S  N  +  G  L I +    E D G YT  +TN   K  +    SL V V P I +K  I  V S        + C +    P  +I W +Q                 P+PC+E +         + +        I+ +  N   S   +  +NV   + +C A +K G+   +VI     R  E  L+  P  +  E+E   L CT     F NLTW                    K  D   +L   M    T  IL     ++ + N++  D G Y C+    + +    +V    V+ ++ AP +T +L+       E+  ++C    +P   + WFK+ + LV             D G    L D ++N   +R R        K + G Y+C+A + LG A+ +   ++
Sbjct:  291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVR--IPAKYLGYPPPEIKWYKNGIPLES--NHTIKAGHVLTIME--VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGK--NKTVSTLVIQAANVSALY-KCEAVNKVGRG-ERVISFHVTRGPEITLQ--PDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDIL-----IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERV-APTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLV------------EDSG--IVLKDGNRNLTIRRVR--------KEDEGLYTCQACSVLGCAKVEAFFII 754
The following BLAST results are available for this feature:
BLAST of Incomplete threonine/tyrosine kinase protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
VGFR24.492e-8232.28Vascular endothelial growth factor receptor 2 OS=H... [more]
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