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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00016517-protein ID=TCONS_00016517-protein|Name=TCONS_00016517-protein|organism=Clytia hemisphaerica|type=polypeptide|length=625bp
MKRWSLLFWIFCQIQGAFQTPVSRPRSITIESSQSTLNSISRIQLIRSTS
SPVKTTAQLNSTKRCNDKTCQQFHQSPTCSRVLGLTNQTTVKRDCRYGNN
ELEYHISRIIRLVDKDRSIDGACRNLTHWFLCSLVFPSCNVQNGSLLPCQ
ETCNQVNDCYSNIKEVILTHDRTFYEHLRTDCLLLGKQKDGKCAFKALQR
QMNTKPAPFKFVTLIVIGTVIWVVLIFLVILFIIYRRRHNNAFSRTLSLH
EVKNVHSNRTVQVNDNFENLGITNPKYESVISLVTTLGLTVFSKENLVFD
RNLGEGAFGKVVKCRTKSIDHPKLGTVEMVAVKYLKENAEAEMELTFQRE
LEILSNFDHPNVIPLVGVCLDKSGPMCLILEFMKYGDLNQYIRLRSGSFH
AVAGSCGDLPDGVEFQSPELSYHNLLSITSQIADGVSYLASKRFVHRDIA
TRNILVGENLKVKISDFGLAHDIYGSDYYRVSSQKLLPLRWLSPEALSLG
KFTVYSDTFAFGVTMWEIFTYGMQPYYGLNNEEVCNMIRGHKLLERPYCC
PPNIYALMKSCWKFEPRHRKDLVFIRDTIDSWLEADETFIRESWKRLMLP
PLSERRPTILKSKKFNRLIKRDITL Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0004672 | protein kinase activity |
| GO:0004713 | protein tyrosine kinase activity |
| GO:0005515 | protein binding |
| GO:0005524 | ATP binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0006468 | protein phosphorylation |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
Vocabulary: Cellular Component
| Term | Definition |
|---|
| GO:0016020 | membrane |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0006468 |
protein phosphorylation |
| biological_process |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
| cellular_component |
GO:0016020 |
membrane |
| molecular_function |
GO:0005524 |
ATP binding |
| molecular_function |
GO:0005515 |
protein binding |
| molecular_function |
GO:0004672 |
protein kinase activity |
| molecular_function |
GO:0004713 |
protein tyrosine kinase activity |
| molecular_function |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | PRINTS | PR00109 | TYRKINASE | coord: 506..528
score: 52.11
coord: 438..456
score: 59.67
coord: 550..572
score: 36.49
coord: 380..393
score: 38.05
coord: 487..497
score: 52.05 |
| IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | PFAM | PF07714 | Pkinase_Tyr | coord: 298..576
e-value: 2.7E-85
score: 285.7 |
| IPR020635 | Tyrosine-protein kinase, catalytic domain | SMART | SM00219 | tyrkin_6 | coord: 297..579
e-value: 1.7E-112
score: 389.7 |
| IPR020067 | Frizzled domain | PFAM | PF01392 | Fz | coord: 70..164
e-value: 1.5E-7
score: 32.0 |
| IPR020067 | Frizzled domain | GENE3D | 1.10.2000.10 | | coord: 49..190
e-value: 8.3E-10
score: 38.5 |
| IPR020067 | Frizzled domain | PROSITE | PS50038 | FZ | coord: 65..196
score: 10.149 |
| IPR020067 | Frizzled domain | SUPERFAMILY | 63501 | Frizzled cysteine-rich domain | coord: 69..166 |
| None | No IPR available | PIRSF | PIRSF000615 | TyrPK_CSF1-R | coord: 408..599
e-value: 9.6E-48
score: 160.9
coord: 118..240
e-value: 0.0027
score: 13.8
coord: 291..412
e-value: 2.2E-17
score: 60.4
coord: 1..120
e-value: 39.0
score: 0.0 |
| None | No IPR available | GENE3D | 3.30.200.20 | | coord: 291..387
e-value: 1.0E-22
score: 79.6 |
| None | No IPR available | GENE3D | 1.10.510.10 | | coord: 388..613
e-value: 2.7E-42
score: 144.3 |
| None | No IPR available | CDD | cd00192 | PTKc | coord: 303..569
e-value: 3.84616E-109
score: 330.655 |
| IPR017441 | Protein kinase, ATP binding site | PROSITE | PS00107 | PROTEIN_KINASE_ATP | coord: 303..333 |
| IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site | PROSITE | PS00239 | RECEPTOR_TYR_KIN_II | coord: 472..480 |
| IPR008266 | Tyrosine-protein kinase, active site | PROSITE | PS00109 | PROTEIN_KINASE_TYR | coord: 444..456 |
| IPR000719 | Protein kinase domain | PROSITE | PS50011 | PROTEIN_KINASE_DOM | coord: 297..583
score: 36.499 |
| IPR011009 | Protein kinase-like domain | SUPERFAMILY | 56112 | Protein kinase-like (PK-like) | coord: 278..571 |
Blast
BLAST of TCONS_00016517-protein vs. Swiss-Prot (Human)
Match: MUSK (Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens GN=MUSK PE=1 SV=1) HSP 1 Score: 261.922 bits (668), Expect = 5.907e-77 Identity = 133/303 (43.89%), Postives = 189/303 (62.38%), Query Frame = 0
Query: 292 FSKENLVFDRNLGEGAFGKVVKCRTKSIDHPKLGTVE---MVAVKYLKENAEAEMELTFQRELEILSNFDHPNVIPLVGVCLDKSGPMCLILEFMKYGDLNQYIRLRSGSFHAVAG-SCGDLPDGVEFQSP---ELSYHNLLSITSQIADGVSYLASKRFVHRDIATRNILVGENLKVKISDFGLAHDIYGSDYYRVSSQKLLPLRWLSPEALSLGKFTVYSDTFAFGVTMWEIFTYGMQPYYGLNNEEVCNMIRGHKLLERPYCCPPNIYALMKSCWKFEPRHRKDLVFIRDTIDSWLEADE 587
+ + N+ + R++GEGAFG+V + R P L E MVAVK LKE A A+M+ FQRE +++ FD+PN++ L+GVC PMCL+ E+M YGDLN++ LRS S H V S DL + SP LS L I Q+A G++YL+ ++FVHRD+ATRN LVGEN+ VKI+DFGL+ +IY +DYY+ + +P+RW+ PE++ ++T SD +A+GV +WEIF+YG+QPYYG+ +EEV +R +L P CP +Y LM+ CW P R I ++ E E
Sbjct: 570 YPRNNIEYVRDIGEGAFGRVFQARA-----PGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCA-VGKPMCLLFEYMAYGDLNEF--LRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 864
The following BLAST results are available for this feature:
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