TCONS_00014711-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00014711-protein
Unique NameTCONS_00014711-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1254

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00014711-protein ID=TCONS_00014711-protein|Name=TCONS_00014711-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1254bp
MIETRQVKEEVKKTLLERIMIFDGGMGTMIQNLELEEDDFRGDEFKDHSK
LLRGNNDLLSLTQPEKIYEIHKAYLEAGADFIETNTFSGTSIAQADYALE
HLVYRLNKVSAELARKAADDVTEITGCQKYVAGAMGPTNRTLSISPSVEN
PGYRNVTFDELVDAYTEQAKGLLDGGADVLLVETIFDTANSKAALFAIES
LFEKEYRPVPIFVSGTIVDKSGRTLSGQTTEAFVTSVQHANPLCIGLNCA
LGAEDMRPFVERMGLSYEGFVLCYPNAGLPNAFGGYDETPEEMSATLKVF
AEDGLVNIVGGCCGTTPEHIHAIKEATKHCKPRSLPDPINQDCMVLSGLE
PKYITPESIFVNIGERCNVAGSRRFCNLIKKGKFEDALAIAKSQVENGAQ
ILDINMDDGLLDGEKCMTDFCKLIASEPDISKVPLCIDSSKFEVIEAGLK
CAQGKSIVNSISLKNGEEDFIEKALLIKKYGAAVVIMAFDEEGQAASLER
RIEICKRSYDILVDRVHFNANDIIFDSNILTIATGMEEHNEYAIDFIKAV
AEIKKLCPGSRCSGGLSNLSFSFRGMDVVRDALHAVFLYHAIKAGLDMAI
VNAGTIPLYDDIPQDLLNLCEDLIWNKNTEATDKMLEFAQKQSKTGNKPQ
TDEEWRKEHVCKRLEYALIKGIDKYVTNDVEEARQMKEDFPRPLNIIEGP
LMSGMSIVGDRFGAGKMFLPQVIKSARVMKKAVGYLVPFMEIEKAEMNAN
SGEETPDLSSLYSGTIVIATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVM
TPCEKILQTAIEENADIIGLSGLITPSLDEMIHVAKEMERKGMKTPLLIG
GATTSRTHTAVKIAPRYSNPTIHVLDASKSAVVAQALMDEDSRLELTEET
VEEYDEIREDFKDSIKDRKYTSIETARQSKFTLDWDGFEPVKPTFVGNKI
YKDLPIQQLVSYIDWKPFFDIWQLRGRYPNRGFPKIFKDKTVGEEAQRVY
NDAQSMLNKIISNKSMKAVGQVTFVEANSVEDDIHLYQRNEDGERIHFQT
FYGIRQQAEKETKEKSYMCISDFVAPLCANKTDYVGMFVVSCLGAEELAK
QYEDLFDDYSSIMVKAIADRLAEAFAEKLHEMVRRDLWGYSNEESLSESD
LLKVKYQGIRPAPGYPTQPDHLEKQTMWKIMEAEKNISVELTESLAMFPA
ASVSGLYFAHPKSHYFATGKICKDQVEDYANRKKKPIKEIETWLSPVLAY
EPDC
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_008233XLOC_008233Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00014711TCONS_00014711Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR003759Cbl-bd_cap
IPR003726HCY_dom
IPR011822MetH
IPR004223VitB12-dep_Met_synth_activ_dom
IPR000489Pterin-binding_dom
IPR006158Cobalamin-bd
IPR033706Met_synthase_B12-bd
IPR011005Dihydropteroate_synth-like
Vocabulary: Molecular Function
TermDefinition
GO:0008270zinc ion binding
GO:0031419cobalamin binding
GO:0008705methionine synthase activity
GO:0046872metal ion binding
Vocabulary: Biological Process
TermDefinition
GO:0009086methionine biosynthetic process
GO:0042558pteridine-containing compound metabolic process
GO:0044237cellular metabolic process
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0044237 cellular metabolic process
biological_process GO:0009086 methionine biosynthetic process
biological_process GO:0042558 pteridine-containing compound metabolic process
molecular_function GO:0031419 cobalamin binding
molecular_function GO:0046872 metal ion binding
molecular_function GO:0008705 methionine synthase activity
molecular_function GO:0008270 zinc ion binding
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003759Cobalamin (vitamin B12)-binding module, cap domainSMARTSM01018B12_binding_2_2coord: 658..744
e-value: 3.6E-37
score: 139.5
IPR003759Cobalamin (vitamin B12)-binding module, cap domainGENE3D1.10.1240.10coord: 653..741
e-value: 3.9E-32
score: 109.7
IPR003759Cobalamin (vitamin B12)-binding module, cap domainPFAMPF02607B12-binding_2coord: 661..736
e-value: 1.1E-21
score: 77.0
IPR003759Cobalamin (vitamin B12)-binding module, cap domainPROSITEPS51337B12_BINDING_NTERcoord: 651..748
score: 35.154
IPR003759Cobalamin (vitamin B12)-binding module, cap domainSUPERFAMILY47644Methionine synthase domaincoord: 653..741
NoneNo IPR availableGENE3D3.40.50.280coord: 744..922
e-value: 1.7E-54
score: 183.1
NoneNo IPR availableGENE3D3.20.20.20coord: 350..648
e-value: 2.7E-64
score: 216.6
NoneNo IPR availableCDDcd00740MeTrcoord: 360..616
e-value: 5.32806E-120
score: 373.651
IPR003726Homocysteine-binding domainGENE3D3.20.20.330coord: 3..343
e-value: 5.1E-109
score: 363.9
IPR003726Homocysteine-binding domainPFAMPF02574S-methyl_transcoord: 20..326
e-value: 2.2E-78
score: 263.7
IPR003726Homocysteine-binding domainPROSITEPS50970HCYcoord: 8..327
score: 56.101
IPR003726Homocysteine-binding domainSUPERFAMILY82282Homocysteine S-methyltransferasecoord: 12..403
IPR011822Cobalamin-dependent methionine synthasePIRSFPIRSF000381Met_synth_MetHcoord: 4..1221
e-value: 0.0
score: 1671.2
IPR011822Cobalamin-dependent methionine synthaseTIGRFAMTIGR02082TIGR02082coord: 17..1217
e-value: 0.0
score: 1722.6
IPR004223Vitamin B12-dependent methionine synthase, activation domainGENE3D3.10.196.10coord: 1106..1254
e-value: 3.6E-57
score: 192.9
coord: 979..1105
e-value: 7.8E-38
score: 129.5
IPR004223Vitamin B12-dependent methionine synthase, activation domainPFAMPF02965Met_synt_B12coord: 956..1234
e-value: 3.0E-111
score: 371.1
IPR004223Vitamin B12-dependent methionine synthase, activation domainPROSITEPS50974ADOMET_ACTIVATIONcoord: 914..1253
score: 88.88
IPR004223Vitamin B12-dependent methionine synthase, activation domainSUPERFAMILY56507Methionine synthase activation domain-likecoord: 918..1253
IPR000489Pterin-binding domainPFAMPF00809Pterin_bindcoord: 364..602
e-value: 4.7E-52
score: 177.0
IPR000489Pterin-binding domainPROSITEPS50972PTERIN_BINDINGcoord: 360..621
score: 28.059
IPR006158Cobalamin (vitamin B12)-binding domainPFAMPF02310B12-bindingcoord: 765..856
e-value: 1.1E-18
score: 67.3
IPR006158Cobalamin (vitamin B12)-binding domainPROSITEPS51332B12_BINDINGcoord: 763..898
score: 44.276
IPR006158Cobalamin (vitamin B12)-binding domainSUPERFAMILY52242Cobalamin (vitamin B12)-binding domaincoord: 764..910
IPR033706Methionine synthase, B12-binding domainCDDcd02069methionine_synthase_B12_BDcoord: 662..888
e-value: 1.99427E-118
score: 367.745
IPR011005Dihydropteroate synthase-likeSUPERFAMILY51717Dihydropteroate synthetase-likecoord: 360..634

Blast
[Close]
BLAST of TCONS_00014711-protein vs. Swiss-Prot (Human)
Match: METH (Methionine synthase OS=Homo sapiens GN=MTR PE=1 SV=2)

HSP 1 Score: 1722.21 bits (4459), Expect = 0.000e+0
Identity = 823/1255 (65.58%), Postives = 996/1255 (79.36%), Query Frame = 0 
Query:    5 RQVKEEVKKTLLERIMIFDGGMGTMIQNLELEEDDFRGDEFKDHSKLLRGNNDLLSLTQPEKIYEIHKAYLEAGADFIETNTFSGTSIAQADYALEHLVYRLNKVSAELARKAADDVTEITGCQKYVAGAMGPTNRTLSISPSVENPGYRNVTFDELVDAYTEQAKGLLDGGADVLLVETIFDTANSKAALFAIESLFEKEYRPVPIFVSGTIVDKSGRTLSGQTTEAFVTSVQHANPLCIGLNCALGAEDMRPFVERMGLSYEGFVLCYPNAGLPNAFGGYDETPEEMSATLKVFAEDGLVNIVGGCCGTTPEHIHAIKEATKHCKPRSLPDPINQDCMVLSGLEPKYITPESIFVNIGERCNVAGSRRFCNLIKKGKFEDALAIAKSQVENGAQILDINMDDGLLDGEKCMTDFCKLIASEPDISKVPLCIDSSKFEVIEAGLKCAQGKSIVNSISLKNGEEDFIEKALLIKKYGAAVVIMAFDEEGQAASLERRIEICKRSYDILVDRVHFNANDIIFDSNILTIATGMEEHNEYAIDFIKAVAEIKKLCPGSRCSGGLSNLSFSFRGMDVVRDALHAVFLYHAIKAGLDMAIVNAGTIPLYDDIPQDLLNLCEDLIWNKNTEATDKMLEFAQKQSKTGNKPQTDEEWRKEHVCKRLEYALIKGIDKYVTNDVEEARQMKEDFPRPLNIIEGPLMSGMSIVGDRFGAGKMFLPQVIKSARVMKKAVGYLVPFMEIEKAE---MNANSGEETPDLSSLYSGTIVIATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCEKILQTAIEENADIIGLSGLITPSLDEMIHVAKEMERKGMKTPLLIGGATTSRTHTAVKIAPRYSNPTIHVLDASKSAVVAQALMDEDSRLELTEETVEEYDEIREDFKDSIKDRKYTSIETARQSKFTLDW-DGFEPVKPTFVGNKIYKDLPIQQLVSYIDWKPFFDIWQLRGRYPNRGFPKIFKDKTVGEEAQRVYNDAQSMLNKIISNKSMKAVGQVTFVEANSVEDDIHLYQRNEDGERIH-FQTFYGIRQQAEKETKE-KSYMCISDFVAPLCANKTDYVGMFVVSCLGAEELAKQYEDLFDDYSSIMVKAIADRLAEAFAEKLHEMVRRDLWGYSNEESLSESDLLKVKYQGIRPAPGYPTQPDHLEKQTMWKIMEAEKNISVELTESLAMFPAASVSGLYFAHPKSHYFATGKICKDQVEDYANRKKKPIKEIETWLSPVLAYEPD 1253
            + +++E+   L +RIM+ DGGMGTMIQ  +L E+ FRG EFKDH++ L+GNND+LS+TQP+ IY+IHK YL AGAD IETNTFS TSIAQADY LEHL YR+N  SA +ARKAA++VT  TG +++VAGA+GPTN+TLS+SPSVE P YRN+TFDELV+AY EQAKGLLDGG D+LL+ETIFDTAN+KAALFA+++LFE++Y P PIF+SGTIVDKSGRTLSGQT E FV SV H  PLCIGLNCALGA +MRPF+E +G     +VLCYPNAGLPN FG YDETP  M+  LK FA DGLVNIVGGCCG+TP+HI  I EA K+CKPR  P    +  M+LSGLEP  I P + FVNIGERCNVAGSR+F  LI  G +E+AL +AK QVE GAQ+LD+NMDDG+LDG   MT FC LIASEPDI+KVPLCIDSS F VIEAGLKC QGK IVNSISLK GE+DF+EKA  IKKYGAA+V+MAFDEEGQA   + +I +C R+Y +LV ++ FN NDIIFD NILTI TGMEEHN YAI+FI A   IK+  PG+R SGGLSNLSFSFRGM+ +R+A+H VFLYHAIK+G+DM IVNAG +P+YDDI ++LL LCEDLIWNK+ EAT+K+L +AQ Q   G K    +EWR   V +RLEYAL+KGI+K++  D EEAR  ++ +PRPLNIIEGPLM+GM IVGD FGAGKMFLPQVIKSARVMKKAVG+L+PFME E+ E   +N    EE P     Y GTIV+ATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPC+KIL+ A++  ADIIGLSGLITPSLDEMI VAKEMER  ++ PLLIGGATTS+THTAVKIAPRYS P IHVLDASKS VV   L+DE+ + E  EE +EEY++IR+D  +S+K+R+Y  +  AR+S F +DW     PVKPTF+G ++++D  +Q+LV YIDWKPFFD+WQLRG+YPNRGFPKIF DKTVG EA++VY+DA +MLN +IS K ++A G V F  A S++DDIHLY      +      TFYG+RQQAEK++   + Y C+SDF+APL +   DY+G+F V+C G EEL+K YED  DDYSSIMVKA+ DRLAEAFAE+LHE VRR+LW Y   E L  +DL +++Y+GIRPAPGYP+QPDH EK TMW++ + E++  + LTESLAM PA++VSGLYF++ KS YFA GKI KDQVEDYA RK   + E+E WL P+L Y+ D
Sbjct:   16 KTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDP-----YQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 1265
The following BLAST results are available for this feature:
BLAST of TCONS_00014711-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
METH0.000e+065.58Methionine synthase OS=Homo sapiens GN=MTR PE=1 SV... [more]
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