TCONS_00066769-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00066769-protein
Unique NameTCONS_00066769-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length642

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00066769-protein ID=TCONS_00066769-protein|Name=TCONS_00066769-protein|organism=Clytia hemisphaerica|type=polypeptide|length=642bp
MVALEWQMAINWVRSTDIEPAKKQALNKIDDLLEFAQSLRDGYILCLVAN
SLRPGTIKDISKINNVNMHEFLCNRNIRAFLKACTTVFKLDDKKLFKAKE
LYEATNFEAVIKTLSHLSKTSIAKGAGLKPFPPDDYKKQNHQEQEEDIYG
SLGEILEEREEKTDYYNYDEQEEDIYDHVEVSEKIYDDIVQCTRQAHAAT
KPAASDKRSHIVNEIIETEDTYVNHLKVMVEQYIKPLKAHMSSQDKETIF
INTEPLYLFHMTFKRELSTRRTSTNVKLNLNAFDKYKDKFLIYATYCTGL
EEAQQHTIELSKESGFRDKVEQCNKTAKRKFPLQEQLMIPFQRILKYPLL
LRDLNKHTPETHEDKKAVEQAYDLMDDVARYINEYKRDAEAVKVLAQIEG
SIKYEMQAQGSKGGQYGRYVKCGEIQVKFDSQEKKVIKRFAFLFQKSILL
CKQRGDYYDVKEIFDMQKFKIADVPPVGKGKFSQGWSMQAHAPDGVTEHK
NCTMFAKTQQEKINWVSEISKCIEAVTLSQYEGKLDKHQFELTTFEKPQC
CTVCNKLLRGQVSQGYKCSNIECGAIVHKDCLVKCPRCKIAPSRPLNPKP
TSGRSMKSYEWSTTSIPNAHKSPPAQQVSQMQISDSFSKYHW
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_041754XLOC_041754Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00066769TCONS_00066769Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001849PH_domain
IPR002219PE/DAG-bd
IPR000219DH-domain
IPR001715CH-domain
IPR011993PH_dom-like
Vocabulary: Biological Process
TermDefinition
GO:0035556intracellular signal transduction
GO:0035023regulation of Rho protein signal transduction
Vocabulary: Molecular Function
TermDefinition
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005515protein binding
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0035556 intracellular signal transduction
biological_process GO:0035023 regulation of Rho protein signal transduction
molecular_function GO:0005515 protein binding
molecular_function GO:0005089 Rho guanyl-nucleotide exchange factor activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 419..526
e-value: 1.8E-6
score: 37.5
IPR001849Pleckstrin homology domainPFAMPF00169PHcoord: 421..523
e-value: 7.1E-6
score: 26.4
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainSMARTSM00109c1_12coord: 538..588
e-value: 9.6E-8
score: 41.7
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainPFAMPF00130C1_1coord: 538..586
e-value: 1.1E-7
score: 31.5
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainPROSITEPS50081ZF_DAG_PE_2coord: 537..588
score: 10.328
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainCDDcd00029C1coord: 538..584
e-value: 1.5694E-11
score: 59.428
IPR000219Dbl homology (DH) domainSMARTSM00325RhoGEF_3coord: 211..384
e-value: 2.3E-45
score: 166.7
IPR000219Dbl homology (DH) domainPFAMPF00621RhoGEFcoord: 211..383
e-value: 5.0E-41
score: 140.8
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 207..385
score: 32.467
IPR000219Dbl homology (DH) domainSUPERFAMILY48065DBL homology domain (DH-domain)coord: 201..402
IPR001715Calponin homology domainSMARTSM00033ch_5coord: 5..117
e-value: 4.8E-13
score: 59.3
IPR001715Calponin homology domainPFAMPF00307CHcoord: 5..120
e-value: 2.5E-11
score: 43.6
IPR001715Calponin homology domainGENE3D1.10.418.10coord: 2..180
e-value: 1.3E-29
score: 102.4
IPR001715Calponin homology domainPROSITEPS50021CHcoord: 3..121
score: 13.157
IPR001715Calponin homology domainSUPERFAMILY47576Calponin-homology domain, CH-domaincoord: 6..139
NoneNo IPR availableGENE3D1.20.900.10coord: 195..401
e-value: 4.2E-52
score: 176.2
NoneNo IPR availableGENE3D3.30.60.20coord: 532..601
e-value: 2.2E-12
score: 46.1
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 596..642
NoneNo IPR availableCDDcd00160RhoGEFcoord: 208..383
e-value: 2.55162E-41
score: 147.059
IPR011993PH domain-likeGENE3D2.30.29.30coord: 403..531
e-value: 7.3E-15
score: 54.4
IPR011993PH domain-likeSUPERFAMILY50729PH domain-likecoord: 414..561

Blast
[Close]
BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)
Match: VAV3 (Guanine nucleotide exchange factor VAV3 OS=Homo sapiens GN=VAV3 PE=1 SV=1)

HSP 1 Score: 299.286 bits (765), Expect = 1.131e-90
Identity = 208/649 (32.05%), Postives = 340/649 (52.39%), Query Frame = 0 
Query:    6 WQMAINWVRSTDIEPAKKQALNKIDDLLEFAQSLRDGYILCLVANSLRPGTIKDISKIN-NVNMHEFLCNRNIRAFLKACTTVFKLDDKKLFKAKELYEATNFEAVIKTLSHLSKTSIAKGAGLKPFPPDDYKKQNHQEQEEDIYGSLGEILEEREEKTDYYNYDEQEEDIYDHV---EVSEKIYDDIVQCTRQAHAATKPAASDKRSHIVNEIIETEDTYVNHLKVMVEQYIKPLKAHMSSQDKETIFINTEPLYLFHMTFKRELSTRRTSTNVKLNLNAFDKYKDKFLIYATYCTGLEEAQQHTIELSK-ESGFRDKVEQCNKTAKR-KFPLQEQLMIPFQRILKYPLLLRDLNKHTPETHEDKKAVEQAYDLMDDVARYINEYKRDAEAVKVLAQIEGSIKYEMQAQGSKGGQYGRYVKCGEIQV-KFDSQEKKVIKRFAFLFQKSILLCKQRGDYYDVKEIFDMQKFKIADVPPVGK--GKFSQGWSM-QAHAPDGVTEHKNCTMFAKTQQEKINWVSEISKCIEAVTLSQYEGKLDKHQFELTTFEKPQCCTVCNKLLRGQVSQGYKCSNIECGAIVHKDCLVKCPRCKIAPSR-----PLNPKPTSG--RSMKSYE-----------WSTTSIPNAHKSPPAQ 626
            W+    W+    + P   +       + + AQ+LRDG +LC + N+LR  +I ++ +IN    M +FLC +NIR FL AC   F +   +LF+A +L++  +F  VI+TLS LS+T IA   G++PFP ++         +EDIY  L ++++E           E EED+YD V   +   ++Y+D+++   +AH    P  +D RS  + EI +TE+ Y   L+ + + ++ PLK  +++ + +++FIN   L   H    +E+     + N +     F  YK++ +IY  YC+G+E A      +SK +   + K+E+C+K A   KF L++ L++P QR+LKY LLL++L KHT +  E K  ++ A D M D+A+Y+NE KRD E ++ + Q + SI+   Q        +GR    GEI++   D   K+  +R  FLF  ++++CK++GD Y++KEI D+Q++KIA+ P   K   K+S G+ +      +G+        + KT+  K  W+ +    +  +     +     H F++ TF +   C VC  LLRG   QGY C   +CGA  HK+CL +   C    S       L  K T+G  R+ K  +           +S T  P  H+ PP Q
Sbjct:    4 WKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSI-NLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEE------SINDEDIYKGLPDLIDE--------TLVEDEEDLYDCVYGEDEGGEVYEDLMK-AEEAHQPKCP-ENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTE-KANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPV----LLFGRPQGDGEIRITTLDKHTKQ--ERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL------EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNF--HDFKMHTFTRVTSCKVCQMLLRGTFYQGYLC--FKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQ 618
The following BLAST results are available for this feature:
BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
VAV31.131e-9032.05Guanine nucleotide exchange factor VAV3 OS=Homo sa... [more]
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