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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00001125-protein ID=TCONS_00001125-protein|Name=TCONS_00001125-protein|organism=Clytia hemisphaerica|type=polypeptide|length=579bp MSFRSKERLLKLLPRRSPRLLAKSQSTSDISSSMVDLGLKGAKELHKSHS MVRPGHSFRPVIMKKQKAKQKEEANKTKSLKRMRESAVSLRSIENVMPTP MKRIKSSTSQKDIALKAIDAIKEHPPKKRFSTRVATFAKGLSPSNSFRRK RYQDSKLPASRSFDNNENDKIDKITVKKSSEVQRSTSLRLPRNQTAANNV FYQSQRKQRKTSCVTPARRRGSKLWVDSFEYDESDGWTPQQIKRQEAIYE LYCGETDMVEDLKLLQEVYFNPVAKLKLLTEEDLASIFGNIQVLLPLHED LVKRLEEVRTENGSIEEIGRILTEWIPTLRPYIPYCANQLQMKNMLLHKT KENKHFSDFLQRCLESPFSRKLDLWSFLDSPRSKLVKYPLLISNMHKYTP KEHPDNIILYQAIQELEVIIKEADKATGKSKSSFYKDRMYFLDEGDHREA LSQAQVLLCHGSLKNKNGGKIEAFLFDTVFLITRPASRNGMEMYQVLSQP LLTNDMEYANVSDGELRLGGSFRSSLTKGPTAKFAFRVNPKELTRGKSII LQANDQHDKKQWLNALSKVASMPSKGDPS Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Biological Process
Term | Definition |
GO:0035023 | regulation of Rho protein signal transduction |
GO:0035556 | intracellular signal transduction |
Vocabulary: Molecular Function
Term | Definition |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
GO:0005085 | guanyl-nucleotide exchange factor activity |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category |
Term Accession |
Term Name |
biological_process |
GO:0035556 |
intracellular signal transduction |
biological_process |
GO:0035023 |
regulation of Rho protein signal transduction |
molecular_function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
molecular_function |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
IPR000219 | Dbl homology (DH) domain | SMART | SM00325 | RhoGEF_3 | coord: 247..425 e-value: 9.2E-41 score: 151.4 |
IPR000219 | Dbl homology (DH) domain | PFAM | PF00621 | RhoGEF | coord: 248..422 e-value: 1.7E-35 score: 122.8 |
IPR000219 | Dbl homology (DH) domain | PROSITE | PS50010 | DH_2 | coord: 243..426 score: 29.485 |
IPR000219 | Dbl homology (DH) domain | SUPERFAMILY | 48065 | DBL homology domain (DH-domain) | coord: 228..430 |
None | No IPR available | GENE3D | 1.20.900.10 | | coord: 221..438 e-value: 2.1E-49 score: 167.3 |
None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 67..88 |
None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 144..166 |
None | No IPR available | CDD | cd00160 | RhoGEF | coord: 244..424 e-value: 2.68185E-36 score: 132.422 |
IPR011993 | PH domain-like | GENE3D | 2.30.29.30 | | coord: 442..572 e-value: 3.6E-14 score: 52.4 |
IPR011993 | PH domain-like | SUPERFAMILY | 50729 | PH domain-like | coord: 444..569 |
IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PROSITE | PS00741 | DH_1 | coord: 374..399 |
IPR001849 | Pleckstrin homology domain | PROSITE | PS50003 | PH_DOMAIN | coord: 533..571 score: 8.035 |
Blast
BLAST of TCONS_00001125-protein vs. Swiss-Prot (Human)
Match: ARHG8 (Neuroepithelial cell-transforming gene 1 protein OS=Homo sapiens GN=NET1 PE=1 SV=1) HSP 1 Score: 340.887 bits (873), Expect = 8.202e-110 Identity = 162/376 (43.09%), Postives = 245/376 (65.16%), Query Frame = 0 Query: 204 SQRKQRKTSCVTPARRRGSKLWVDSFEYDESDGWTPQQIKRQEAIYELYCGETDMVEDLKLLQEVYFNPVAKLKLLTEEDLASIFGNIQVLLPLHEDLVKRLEEVRTENGSIEEIGRILTEWIPTLRPYIPYCANQLQMKNMLLHKTKENKHFSDFLQRCLESPFSRKLDLWSFLDSPRSKLVKYPLLISNMHKYTPKEHPDNIILYQAIQELEVIIKEADKATGKSKSSFYKDRMYFLDEGDHREALSQAQVLLCHGSLKNKNGGKIEAFLFDTVFLITRPASRNGMEMYQVLSQPLLTNDMEYANVSDGELRLGGSFRSSLTKGPTAKFAFRVNPKELTRGKSIILQANDQHDKKQWLNAL-SKVASMPSKGDP 578
+Q+ +++ TPA+RR S LW + + + T ++I+RQEAIYE+ GE D++EDLKL ++ Y +P+ KL +++EE+L IFG++ +PLHEDL+ R+ E +G++E+IG IL W+P L Y YC+NQL K LL + K++ DFLQRCLESPFSRKLDLWSFLD PRS+LVKYPLL+ + K+TPKEHPD +L AI ++ ++ + + G+S+ +Y D++ +LDE + ++VLLCHG L++K+G K+ FLF + ++TRP +RN YQV QP+ ++ ++ DG++R+GGSFR + + AK FR+ + + +S LQAND K+QW N + + +A S G P
Sbjct: 135 AQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAK-ALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSP 509
The following BLAST results are available for this feature:
BLAST of TCONS_00001125-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 ( Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match Name | E-value | Identity | Description | |
ARHG8 | 8.202e-110 | 43.09 | Neuroepithelial cell-transforming gene 1 protein O... | [more] |
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