Putative tyrosine kinase receptor protein (polypeptide) - C. hemisphaerica

Overview


Name	Putative tyrosine kinase receptor protein
Unique Name	TCONS_00067023-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	989

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00067023-protein ID=TCONS_00067023-protein|Name=Putative tyrosine kinase receptor protein|organism=Clytia hemisphaerica|type=polypeptide|length=989bp
LDIIYILQLTMNGFHRHTALSLYLLCLKLFQLVVANTQADRATLYFASGK
AFDLPCRNETGGRFATVFWYTDAYTNDNRIRTDVYTYEEGKETIHSEYFE
NRLQRIKGTSLRIKDSKLTDSGKWTCDIVYEETTGGKTGLKVKTMAAYDV
HIVGQPSVIDLSINGLLLKKGESTNVKIPFCESQALSDFNITWTKLSGTM
SSNVKIGTSKPKKIPGPGPLTTYIRRVTLTFTNFSEQDVGQYQCMAKNIG
GELTKVMAARMRKPPLIFSRRVFNIDVGVVNGFLECKAKGYPSMDFTWRV
YPDTPKSNLMHPTEHIDDFKISKTVYDSVSEIGSSRLTISKIKKSHHGKY
ICIASTNDLESTQLEIQLEGKAPPDTPVIIQENTKIEENEVTLFWKVLDD
GGSAVTSVKIDYKNSSTLKDWSSVEVYDRQADSYTIQNLVKGTSYDFRIR
ASNIKGDSDYSEIFTLTTIGLDNGVPTSEPTTDDQILGNLDMTTMIGIFG
GVFIALVVGFICVCIFVRKMQKGEKEDTAPPQQSFASFAPSTTPGTQQRS
MVDGHAAAMEMQPLMMRQPDEWEFPRDRLTITTVLGAGAFGVVMRGLAQG
IKGSVGQITVAVKTVRDTTNEAATKDLIAELNLLKLIPEHQNVVGLLGCC
TYADPLYVIVEYCSNGDLQGFLRSSRGIYERYYRTSYGGAVPNLTSKMLL
TFAWQVAKGMNHLSSMKVIHRDLAARNVLVDDQLVCKVSDFGFARDIYVE
DHYLKRSAGGRFPIKWMAIESLLDGISTTKSDVWSFGVVFWELITLGASP
YPGMNSYEVVSFLQDGYRMDKPKHCADEIYQLMMDCWCVAPGRRPSFVDL
INKCQLLMDEADNKELINMNFYPDHLYVNFDGSNSSAVSTATTPHGTLTR
NHINSVNNKPSNMVDNHSGGGTLGSNHHVQQTPRSKLRSPSNHSMPSGRT
NSVPALSERSLTGASNHSFHANQHPSERVGLLSQMSQPS

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_041863	XLOC_041863	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00067023	TCONS_00067023	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR003599	Ig_sub
IPR003961	FN3_dom
IPR020635	Tyr_kinase_cat_dom
IPR003598	Ig_sub2
IPR013783	Ig-like_fold
IPR008266	Tyr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR007110	Ig-like_dom
IPR000719	Prot_kinase_dom
IPR011009	Kinase-like_dom

Vocabulary: **Molecular Function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

Vocabulary: **Biological Process**
Term	Definition
GO:0006468	protein phosphorylation

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006468	protein phosphorylation
molecular_function	GO:0005524	ATP binding
molecular_function	GO:0005515	protein binding
molecular_function	GO:0004672	protein kinase activity
molecular_function	GO:0004713	protein tyrosine kinase activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01

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IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PRINTS	PR00109	TYRKINASE	coord: 825..847 score: 43.96 coord: 762..772 score: 58.83 coord: 712..730 score: 62.62 coord: 660..673 score: 47.84 coord: 781..803 score: 63.23
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 580..852 e-value: 3.0E-91 score: 305.2
IPR003599	Immunoglobulin subtype	SMART	SM00409	IG_3c	coord: 41..143 e-value: 2.3 score: 17.0 coord: 274..367 e-value: 0.65 score: 19.0 coord: 163..257 e-value: 29.0 score: 7.4
IPR003961	Fibronectin type III	SMART	SM00060	FN3_2	coord: 374..458 e-value: 3.9E-7 score: 39.7
IPR003961	Fibronectin type III	PFAM	PF00041	fn3	coord: 385..461 e-value: 4.0E-9 score: 36.6
IPR003961	Fibronectin type III	PROSITE	PS50853	FN3	coord: 373..471 score: 21.254
IPR003961	Fibronectin type III	CDD	cd00063	FN3	coord: 373..468 e-value: 1.08107E-14 score: 70.6031
IPR003961	Fibronectin type III	SUPERFAMILY	49265	Fibronectin type III	coord: 368..476
IPR020635	Tyrosine-protein kinase, catalytic domain	SMART	SM00219	tyrkin_6	coord: 579..857 e-value: 1.4E-124 score: 429.8
IPR003598	Immunoglobulin subtype 2	SMART	SM00408	igc2_5	coord: 47..133 e-value: 3.2 score: 2.3 coord: 171..251 e-value: 0.0041 score: 26.4 coord: 283..359 e-value: 0.22 score: 13.3
IPR013783	Immunoglobulin-like fold	GENE3D	2.60.40.10		coord: 236..292 e-value: 0.052 score: 13.2
IPR013783	Immunoglobulin-like fold	GENE3D	2.60.40.10		coord: 158..235 e-value: 3.5E-4 score: 20.4
IPR013783	Immunoglobulin-like fold	GENE3D	2.60.40.10		coord: 371..469 e-value: 1.0E-19 score: 70.3
IPR013783	Immunoglobulin-like fold	GENE3D	2.60.40.10		coord: 32..157 e-value: 2.7E-8 score: 33.2
IPR013783	Immunoglobulin-like fold	GENE3D	2.60.40.10		coord: 293..370 e-value: 2.2E-9 score: 36.8
None	No IPR available	GENE3D	1.10.510.10		coord: 662..915 e-value: 1.2E-48 score: 164.7
None	No IPR available	GENE3D	3.30.200.20		coord: 561..661 e-value: 3.2E-20 score: 71.5
None	No IPR available	PFAM	PF13927	Ig_3	coord: 284..355 e-value: 1.5E-7 score: 31.8
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 526..549
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 888..989
None	No IPR available	CDD	cd00096	Ig	coord: 181..255 e-value: 4.238E-5 score: 41.7059
None	No IPR available	CDD	cd00096	Ig	coord: 284..367 e-value: 3.06086E-7 score: 48.2543
None	No IPR available	CDD	cd00192	PTKc	coord: 584..853 e-value: 4.91188E-125 score: 381.887
IPR008266	Tyrosine-protein kinase, active site	PROSITE	PS00109	PROTEIN_KINASE_TYR	coord: 718..730
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 585..613
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 156..262 score: 8.847
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 264..367 score: 9.482
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 49..143 score: 7.159
IPR007110	Immunoglobulin-like domain	SUPERFAMILY	48726	Immunoglobulin	coord: 181..254
IPR007110	Immunoglobulin-like domain	SUPERFAMILY	48726	Immunoglobulin	coord: 45..129
IPR007110	Immunoglobulin-like domain	SUPERFAMILY	48726	Immunoglobulin	coord: 283..379
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 579..858 score: 39.043
IPR011009	Protein kinase-like domain	SUPERFAMILY	56112	Protein kinase-like (PK-like)	coord: 559..852

Blast

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BLAST of Putative tyrosine kinase receptor protein vs. Swiss-Prot (Human)
Match: FGFR1 (Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3)

HSP 1 Score: 294.278 bits (752), Expect = 5.365e-86
Identity = 174/493 (35.29%), Postives = 267/493 (54.16%), Query Frame = 0

Query:  422 SSVEVYDRQADSYTIQNLVKGTSYDFRIRASNIKGDSDYSEIFTLTTIGLDNGVPTSEPTTDDQILGNLDMTTMIGIFGGVFIALVVGFICVCIFVRKMQKGEKEDTAPPQQSFASFAPSTTPGTQQRSMVDGHAAAMEMQPLMMRQ-------------------PDE--WEFPRDRLTITTVLGAGAFGVVMRGLAQGI-KGSVGQIT-VAVKTVRDTTNEAATKDLIAELNLLKLIPEHQNVVGLLGCCTYADPLYVIVEYCSNGDLQGFLRSSRGIYERYYRTSYGGAVPNLTSKMLLTFAWQVAKGMNHLSSMKVIHRDLAARNVLVDDQLVCKVSDFGFARDIYVEDHYLKRSAGGRFPIKWMAIESLLDGISTTKSDVWSFGVVFWELITLGASPYPGMNSYEVVSFLQDGYRMDKPKHCADEIYQLMMDCWCVAPGRRPSFVDLINKCQLLMDEADNKELINMNFYPDHLYVNFDGSNSSAVSTA 891
            + V   D++ +   ++N+    + ++   A N  G S +S   T+     +     + P         L +  +I   G   I+ +VG     + V KM+ G K+     Q +    A S  P  +Q ++    +A+M    L++R                    P++  WE PRDRL +   LG G FG V+   A G+ K    ++T VAVK ++    E    DLI+E+ ++K+I +H+N++ LLG CT   PLYVIVEY S G+L+ +L++ R     Y           L+SK L++ A+QVA+GM +L+S K IHRDLAARNVLV +  V K++DFG ARDI+  D+Y K++  GR P+KWMA E+L D I T +SDVWSFGV+ WE+ TLG SPYPG+   E+   L++G+RMDKP +C +E+Y +M DCW   P +RP+F  L+     ++    N+E ++++   D    +F  + SS  S+ 
Sbjct:  314 AGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSP---------LYLEIIIYCTGAFLISCMVG----SVIVYKMKSGTKKSDFHSQMAVHKLAKSI-PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY-KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSG 791

The following BLAST results are available for this feature:

BLAST of Putative tyrosine kinase receptor protein vs. Swiss-Prot (Human)

BLAST of Putative tyrosine kinase receptor protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1

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Match Name	E-value	Identity	Description
FGFR1	5.365e-86	35.29	Fibroblast growth factor receptor 1 OS=Homo sapien...	[more]

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Putative tyrosine kinase receptor protein (polypeptide) - C. hemisphaerica

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