TCONS_00066769-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00066769-protein
Unique Name	TCONS_00066769-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	642

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00066769-protein ID=TCONS_00066769-protein|Name=TCONS_00066769-protein|organism=Clytia hemisphaerica|type=polypeptide|length=642bp
MVALEWQMAINWVRSTDIEPAKKQALNKIDDLLEFAQSLRDGYILCLVAN
SLRPGTIKDISKINNVNMHEFLCNRNIRAFLKACTTVFKLDDKKLFKAKE
LYEATNFEAVIKTLSHLSKTSIAKGAGLKPFPPDDYKKQNHQEQEEDIYG
SLGEILEEREEKTDYYNYDEQEEDIYDHVEVSEKIYDDIVQCTRQAHAAT
KPAASDKRSHIVNEIIETEDTYVNHLKVMVEQYIKPLKAHMSSQDKETIF
INTEPLYLFHMTFKRELSTRRTSTNVKLNLNAFDKYKDKFLIYATYCTGL
EEAQQHTIELSKESGFRDKVEQCNKTAKRKFPLQEQLMIPFQRILKYPLL
LRDLNKHTPETHEDKKAVEQAYDLMDDVARYINEYKRDAEAVKVLAQIEG
SIKYEMQAQGSKGGQYGRYVKCGEIQVKFDSQEKKVIKRFAFLFQKSILL
CKQRGDYYDVKEIFDMQKFKIADVPPVGKGKFSQGWSMQAHAPDGVTEHK
NCTMFAKTQQEKINWVSEISKCIEAVTLSQYEGKLDKHQFELTTFEKPQC
CTVCNKLLRGQVSQGYKCSNIECGAIVHKDCLVKCPRCKIAPSRPLNPKP
TSGRSMKSYEWSTTSIPNAHKSPPAQQVSQMQISDSFSKYHW

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_041754	XLOC_041754	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00066769	TCONS_00066769	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR001849	PH_domain
IPR002219	PE/DAG-bd
IPR000219	DH-domain
IPR001715	CH-domain
IPR011993	PH_dom-like

Vocabulary: **Biological Process**
Term	Definition
GO:0035556	intracellular signal transduction
GO:0035023	regulation of Rho protein signal transduction

Vocabulary: **Molecular Function**
Term	Definition
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0035556	intracellular signal transduction
biological_process	GO:0035023	regulation of Rho protein signal transduction
molecular_function	GO:0005515	protein binding
molecular_function	GO:0005089	Rho guanyl-nucleotide exchange factor activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001849	Pleckstrin homology domain	SMART	SM00233	PH_update	coord: 419..526 e-value: 1.8E-6 score: 37.5
IPR001849	Pleckstrin homology domain	PFAM	PF00169	PH	coord: 421..523 e-value: 7.1E-6 score: 26.4
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	SMART	SM00109	c1_12	coord: 538..588 e-value: 9.6E-8 score: 41.7
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	PFAM	PF00130	C1_1	coord: 538..586 e-value: 1.1E-7 score: 31.5
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	PROSITE	PS50081	ZF_DAG_PE_2	coord: 537..588 score: 10.328
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	CDD	cd00029	C1	coord: 538..584 e-value: 1.5694E-11 score: 59.428
IPR000219	Dbl homology (DH) domain	SMART	SM00325	RhoGEF_3	coord: 211..384 e-value: 2.3E-45 score: 166.7
IPR000219	Dbl homology (DH) domain	PFAM	PF00621	RhoGEF	coord: 211..383 e-value: 5.0E-41 score: 140.8
IPR000219	Dbl homology (DH) domain	PROSITE	PS50010	DH_2	coord: 207..385 score: 32.467
IPR000219	Dbl homology (DH) domain	SUPERFAMILY	48065	DBL homology domain (DH-domain)	coord: 201..402
IPR001715	Calponin homology domain	SMART	SM00033	ch_5	coord: 5..117 e-value: 4.8E-13 score: 59.3
IPR001715	Calponin homology domain	PFAM	PF00307	CH	coord: 5..120 e-value: 2.5E-11 score: 43.6
IPR001715	Calponin homology domain	GENE3D	1.10.418.10		coord: 2..180 e-value: 1.3E-29 score: 102.4
IPR001715	Calponin homology domain	PROSITE	PS50021	CH	coord: 3..121 score: 13.157
IPR001715	Calponin homology domain	SUPERFAMILY	47576	Calponin-homology domain, CH-domain	coord: 6..139
None	No IPR available	GENE3D	1.20.900.10		coord: 195..401 e-value: 4.2E-52 score: 176.2
None	No IPR available	GENE3D	3.30.60.20		coord: 532..601 e-value: 2.2E-12 score: 46.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 596..642
None	No IPR available	CDD	cd00160	RhoGEF	coord: 208..383 e-value: 2.55162E-41 score: 147.059
IPR011993	PH domain-like	GENE3D	2.30.29.30		coord: 403..531 e-value: 7.3E-15 score: 54.4
IPR011993	PH domain-like	SUPERFAMILY	50729	PH domain-like	coord: 414..561

Blast

[Close]

BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)
Match: VAV3 (Guanine nucleotide exchange factor VAV3 OS=Homo sapiens GN=VAV3 PE=1 SV=1)

HSP 1 Score: 299.286 bits (765), Expect = 1.131e-90
Identity = 208/649 (32.05%), Postives = 340/649 (52.39%), Query Frame = 0

Query:    6 WQMAINWVRSTDIEPAKKQALNKIDDLLEFAQSLRDGYILCLVANSLRPGTIKDISKIN-NVNMHEFLCNRNIRAFLKACTTVFKLDDKKLFKAKELYEATNFEAVIKTLSHLSKTSIAKGAGLKPFPPDDYKKQNHQEQEEDIYGSLGEILEEREEKTDYYNYDEQEEDIYDHV---EVSEKIYDDIVQCTRQAHAATKPAASDKRSHIVNEIIETEDTYVNHLKVMVEQYIKPLKAHMSSQDKETIFINTEPLYLFHMTFKRELSTRRTSTNVKLNLNAFDKYKDKFLIYATYCTGLEEAQQHTIELSK-ESGFRDKVEQCNKTAKR-KFPLQEQLMIPFQRILKYPLLLRDLNKHTPETHEDKKAVEQAYDLMDDVARYINEYKRDAEAVKVLAQIEGSIKYEMQAQGSKGGQYGRYVKCGEIQV-KFDSQEKKVIKRFAFLFQKSILLCKQRGDYYDVKEIFDMQKFKIADVPPVGK--GKFSQGWSM-QAHAPDGVTEHKNCTMFAKTQQEKINWVSEISKCIEAVTLSQYEGKLDKHQFELTTFEKPQCCTVCNKLLRGQVSQGYKCSNIECGAIVHKDCLVKCPRCKIAPSR-----PLNPKPTSG--RSMKSYE-----------WSTTSIPNAHKSPPAQ 626
            W+    W+    + P   +       + + AQ+LRDG +LC + N+LR  +I ++ +IN    M +FLC +NIR FL AC   F +   +LF+A +L++  +F  VI+TLS LS+T IA   G++PFP ++         +EDIY  L ++++E           E EED+YD V   +   ++Y+D+++   +AH    P  +D RS  + EI +TE+ Y   L+ + + ++ PLK  +++ + +++FIN   L   H    +E+     + N +     F  YK++ +IY  YC+G+E A      +SK +   + K+E+C+K A   KF L++ L++P QR+LKY LLL++L KHT +  E K  ++ A D M D+A+Y+NE KRD E ++ + Q + SI+   Q        +GR    GEI++   D   K+  +R  FLF  ++++CK++GD Y++KEI D+Q++KIA+ P   K   K+S G+ +      +G+        + KT+  K  W+ +    +  +     +     H F++ TF +   C VC  LLRG   QGY C   +CGA  HK+CL +   C    S       L  K T+G  R+ K  +           +S T  P  H+ PP Q
Sbjct:    4 WKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSI-NLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEE------SINDEDIYKGLPDLIDE--------TLVEDEEDLYDCVYGEDEGGEVYEDLMK-AEEAHQPKCP-ENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTE-KANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPV----LLFGRPQGDGEIRITTLDKHTKQ--ERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL------EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNF--HDFKMHTFTRVTSCKVCQMLLRGTFYQGYLC--FKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQ 618

The following BLAST results are available for this feature:

BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
VAV3	1.131e-90	32.05	Guanine nucleotide exchange factor VAV3 OS=Homo sa...	[more]

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TCONS_00066769-protein (polypeptide) - C. hemisphaerica