Sequence
The following sequences are available for this feature:
polypeptide sequence
>TCONS_00066769-protein ID=TCONS_00066769-protein|Name=TCONS_00066769-protein|organism=Clytia hemisphaerica|type=polypeptide|length=642bp Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following
gene feature:
This polypeptide derives from the following
transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Biological Process
Term Definition
GO:0035556 intracellular signal transduction GO:0035023 regulation of Rho protein signal transduction
Vocabulary: Molecular Function
Term Definition
GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005515 protein binding
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category
Term Accession
Term Name
biological_process
GO:0035556 intracellular signal transduction
biological_process
GO:0035023 regulation of Rho protein signal transduction
molecular_function
GO:0005515 protein binding
molecular_function
GO:0005089 Rho guanyl-nucleotide exchange factor activity
InterPro
Analysis Name:
InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
50 100 150 200 250 300 350 400 450 500 550 600 Expect = 1.8E-6 / Score = 37.5 Expect = 7.1E-6 / Score = 26.4 Expect = 9.6E-8 / Score = 41.7 Expect = 1.1E-7 / Score = 31.5 Score = 10.328 Expect = 1.5694E-11 / Score = 59.428 Expect = 2.3E-45 / Score = 166.7 Expect = 5.0E-41 / Score = 140.8 Score = 32.467 Score = Expect = 4.8E-13 / Score = 59.3 Expect = 2.5E-11 / Score = 43.6 Expect = 1.3E-29 / Score = 102.4 Score = 13.157 Score = Expect = 4.2E-52 / Score = 176.2 Expect = 2.2E-12 / Score = 46.1 Score = Expect = 2.55162E-41 / Score = 147.059 Expect = 7.3E-15 / Score = 54.4 Score = Sequence SM00233 PF00169 SM00109 PF00130 PS50081 cd00029 SM00325 PF00621 PS50010 SSF48065 SM00033 PF00307 G3DSA:1.10.418.10 PS50021 SSF47576 G3DSA:1.20.900.10 G3DSA:3.30.60.20 mobidb-lite cd00160 G3DSA:2.30.29.30 SSF50729
IPR Term IPR Description Source Source Term Source Description Alignment
IPR001849 Pleckstrin homology domain SMART SM00233 PH_update coord: 419..526 IPR001849 Pleckstrin homology domain PFAM PF00169 PH coord: 421..523 IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain SMART SM00109 c1_12 coord: 538..588 IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain PFAM PF00130 C1_1 coord: 538..586 IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain PROSITE PS50081 ZF_DAG_PE_2 coord: 537..588 IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain CDD cd00029 C1 coord: 538..584 IPR000219 Dbl homology (DH) domain SMART SM00325 RhoGEF_3 coord: 211..384 IPR000219 Dbl homology (DH) domain PFAM PF00621 RhoGEF coord: 211..383 IPR000219 Dbl homology (DH) domain PROSITE PS50010 DH_2 coord: 207..385 IPR000219 Dbl homology (DH) domain SUPERFAMILY 48065 DBL homology domain (DH-domain) coord: 201..402 IPR001715 Calponin homology domain SMART SM00033 ch_5 coord: 5..117 IPR001715 Calponin homology domain PFAM PF00307 CH coord: 5..120 IPR001715 Calponin homology domain GENE3D 1.10.418.10 coord: 2..180 IPR001715 Calponin homology domain PROSITE PS50021 CH coord: 3..121 IPR001715 Calponin homology domain SUPERFAMILY 47576 Calponin-homology domain, CH-domain coord: 6..139 None No IPR available GENE3D 1.20.900.10 coord: 195..401 None No IPR available GENE3D 3.30.60.20 coord: 532..601 None No IPR available MOBIDB_LITE mobidb-lite disorder_prediction coord: 596..642 None No IPR available CDD cd00160 RhoGEF coord: 208..383 IPR011993 PH domain-like GENE3D 2.30.29.30 coord: 403..531 IPR011993 PH domain-like SUPERFAMILY 50729 PH domain-like coord: 414..561
Blast
BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)
Match:
VAV3 (Guanine nucleotide exchange factor VAV3 OS=Homo sapiens GN=VAV3 PE=1 SV=1)
HSP 1 Score: 299.286 bits (765), Expect = 1.131e-90
Identity = 208/649 (32.05%), Postives = 340/649 (52.39%), Query Frame = 0
Query: 6 WQMAINWVRSTDIEPAKKQALNKIDDLLEFAQSLRDGYILCLVANSLRPGTIKDISKIN-NVNMHEFLCNRNIRAFLKACTTVFKLDDKKLFKAKELYEATNFEAVIKTLSHLSKTSIAKGAGLKPFPPDDYKKQNHQEQEEDIYGSLGEILEEREEKTDYYNYDEQEEDIYDHV---EVSEKIYDDIVQCTRQAHAATKPAASDKRSHIVNEIIETEDTYVNHLKVMVEQYIKPLKAHMSSQDKETIFINTEPLYLFHMTFKRELSTRRTSTNVKLNLNAFDKYKDKFLIYATYCTGLEEAQQHTIELSK-ESGFRDKVEQCNKTAKR-KFPLQEQLMIPFQRILKYPLLLRDLNKHTPETHEDKKAVEQAYDLMDDVARYINEYKRDAEAVKVLAQIEGSIKYEMQAQGSKGGQYGRYVKCGEIQV-KFDSQEKKVIKRFAFLFQKSILLCKQRGDYYDVKEIFDMQKFKIADVPPVGK--GKFSQGWSM-QAHAPDGVTEHKNCTMFAKTQQEKINWVSEISKCIEAVTLSQYEGKLDKHQFELTTFEKPQCCTVCNKLLRGQVSQGYKCSNIECGAIVHKDCLVKCPRCKIAPSR-----PLNPKPTSG--RSMKSYE-----------WSTTSIPNAHKSPPAQ 626
W+ W+ + P + + + AQ+LRDG +LC + N+LR +I ++ +IN M +FLC +NIR FL AC F + +LF+A +L++ +F VI+TLS LS+T IA G++PFP ++ +EDIY L ++++E E EED+YD V + ++Y+D+++ +AH P +D RS + EI +TE+ Y L+ + + ++ PLK +++ + +++FIN L H +E+ + N + F YK++ +IY YC+G+E A +SK + + K+E+C+K A KF L++ L++P QR+LKY LLL++L KHT + E K ++ A D M D+A+Y+NE KRD E ++ + Q + SI+ Q +GR GEI++ D K+ +R FLF ++++CK++GD Y++KEI D+Q++KIA+ P K K+S G+ + +G+ + KT+ K W+ + + + + H F++ TF + C VC LLRG QGY C +CGA HK+CL + C S L K T+G R+ K + +S T P H+ PP Q
Sbjct: 4 WKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSI-NLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEE------SINDEDIYKGLPDLIDE--------TLVEDEEDLYDCVYGEDEGGEVYEDLMK-AEEAHQPKCP-ENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTE-KANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPV----LLFGRPQGDGEIRITTLDKHTKQ--ERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL------EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNF--HDFKMHTFTRVTSCKVCQMLLRGTFYQGYLC--FKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQ 618
The following BLAST results are available for this feature:
BLAST of TCONS_00066769-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (
Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens) )
Total hits: 1
M V A L E W Q M A I N W V R S T D I E P A K K Q A L N K I D D L L E F A Q S L R D G Y I L C L V A N S L R P G T I K D I S K I N N V N M H E F L C N R N I R A F L K A C T T V F K L D D K K L F K A K E L Y E A T N F E A V I K T L S H L S K T S I A K G A G L K P F P P D D Y K K Q N H Q E Q E E D I Y G S L G E I L E E R E E K T D Y Y N Y D E Q E E D I Y D H V E V S E K I Y D D I V Q C T R Q A H A A T K P A A S D K R S H I V N E I I E T E D T Y V N H L K V M V E Q Y I K P L K A H M S S Q D K E T I F I N T E P L Y L F H M T F K R E L S T R R T S T N V K L N L N A F D K Y K D K F L I Y A T Y C T G L E E A Q Q H T I E L S K E S G F R D K V E Q C N K T A K R K F P L Q E Q L M I P F Q R I L K Y P L L L R D L N K H T P E T H E D K K A V E Q A Y D L M D D V A R Y I N E Y K R D A E A V K V L A Q I E G S I K Y E M Q A Q G S K G G Q Y G R Y V K C G E I Q V K F D S Q E K K V I K R F A F L F Q K S I L L C K Q R G D Y Y D V K E I F D M Q K F K I A D V P P V G K G K F S Q G W S M Q A H A P D G V T E H K N C T M F A K T Q Q E K I N W V S E I S K C I E A V T L S Q Y E G K L D K H Q F E L T T F E K P Q C C T V C N K L L R G Q V S Q G Y K C S N I E C G A I V H K D C L V K C P R C K I A P S R P L N P K P T S G R S M K S Y E W S T T S I P N A H K S P P A Q Q V S Q M Q I S D S F S K Y H W 50 100 150 200 250 300 350 400 450 500 550 600 Expect = 1.13e-90 / Id = 32.05 Sequence VAV3
Match Name E-value Identity Description
VAV3 1.131e-90 32.05 Guanine nucleotide exchange factor VAV3 OS=Homo sa... [more]
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