TCONS_00052245-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00052245-protein
Unique NameTCONS_00052245-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1842

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00052245-protein ID=TCONS_00052245-protein|Name=TCONS_00052245-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1842bp
MNTAPAKNTDVPDGSHANKKNHRHSYASEPTCFPKRPSWNEESDESDADD
EVEIFKKSGIGRLDVSDNELTVIPPGLPCLAPNLSRLVISKNKITEVDSL
SSLPEHLMALDISDNHLKYFNLMAGKEAEIVNNICYALVRKHSRNSFPQG
KQRKTCLHRKHKQLTELNRLMLNKNSLESLQVCLRNTDKERPNVLFPDLK
ILDISHNKLSKVPPGIGRLKNLSSLILSHNNNLTVLPSELGLCNGLYELK
IESLHLKDPPKNVIENAMHDGRVDVRSLIGYLKSLHDNAQLYPNIKLMIV
GTHGIGKTTLLHALRKEGQGTFKDVDYQCHFNDRRRSQKCLDKGNKSTVG
VDVSDWIYGKKLQIKFSTWDFAGQTEYYATHQCFLSKRALYLVMWRLTDG
LDGIDSMQQWLLNIQERAPNCSVIIVGTFLDEAENKRKNYVEDMRKEIYK
RFVSTKCGGSVPDLAKKGLPKVVQVIEVNSKSQRSVARVRQLIYDTVVAL
KANKNSSTSLLETKIPKSYIDVEKAVTKIMDELNSRHDMPVLNEAKFRKK
VLEHLTLTGCDLRNGTEELDQAVQFLHDYGILLHYDDPALRDLYFVDPQW
LCDMLAHVVTVRSVNPFIKNGVLKISDLKSQIFKGEKRFPTDMVMKYVEL
MSKFEVAIKISEKFLLIPSLLPDKQKECTVIAENESEELRKAMNVNAYLN
GSVLRRQYLMSYVPSGFWARLLTRLIADNRIGKIVSQCCDIQQGKRTSIE
QMKADQETLMRAAPPEWACWKTGIELSCFGAKMLRVCQLGSNEPYYGGKN
SLTSVYVKSRNQESTARVGIEIVAPSLTLTIEKFNHRKPSANDADGEGQN
LVGFRVTGTNYASSQTACKLLVITTEHIDNLLGEWYPKIDTFVDLHGIKA
IRRISFCDRCLREAIEIKGRSGSQLSLNEQYYSNGEITGTEVLAETHEVG
AFASAYDVLDELGVESVTVRLEEGGEVKSKFDTFNNGQDEVDFGPFDLDE
EESDLMTEHRQQGQGKLIAFELEEASKLIRDNKPLLCPFHLQLEAKNVFP
DLCFMDLDKSHIIAHDQLKEGKFLGRGSYGDVFMAELTLDNHPNKNQDRH
NNQPKTIQVAMKIPMNSEKEKNRKMMATMFSYDTYRNVRQELSILGNINH
VNIIRFYGVSVSPFAMLLELAPMGAVDDRYKEYRRVGKRIHPFTIQKSLQ
QISSALKYLHRHHIIYRDLKAENVLVLAFPGPNLVDPIHHQVLLKLTDYG
ISRSVSLGGIKGFLGTPGFMAPEILRYTGKESYTDKVDCFSFGSLIYELI
ALHHPFSDVANDKARLAQIYMQNGKRPRLTSKEKRSPVLLLSLLYRCWAQ
HPEDRPSAAEINALCSLEEFPKLADTIGLAEDFNFQCVTTTNQSRIDSGV
VDSRSVVGSHLWFCGYRGFGAAVAARKEGFITVFSYHDGRYTHVNNIKIR
ERVVQICSVGSFVWIGTEAGHIQVFCALTYKPVAFGFFNLRVILKILHSP
VCGTVFVSLSDGSLHAFDDNISKYNNTIPQNDAVEIFHKADRTTVIRKLE
EKQHFTSQLKIHCMAGVTSFALRRYSQEADGGGDIAVTKRDNSSPRQGKS
RSPSPEAREPTLELWCGQDKGRISILEMKTLREMQTLPVTGTNQDNDFNE
VYNVILIETSRSYDSAINNNQGGSLKTPSPAQVMESAHVWVVAYPGTKIS
RWNVDKRVLEESMDVSQHSPWHDLNSAKPSKKSKSMRAPDAQIVSLVVVE
KQLYVGTTAGCLLVCDAMGHMVPRLSVRCYDEFVDAIIPLRMITSRNPDE
SRKRLVLTCGRKCLDAGIRIIDRKKSIVGKENTFLVWAHLKT
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_033063XLOC_033063Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00052245TCONS_00052245Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR003591Leu-rich_rpt_typical-subtyp
IPR015943WD40/YVTN_repeat-like_dom
IPR0110426-blade_b-propeller_TolB-like
IPR032171COR
IPR032675L_dom-like
IPR013684MIRO-like
IPR008271Ser/Thr_kinase_AS
IPR001611Leu-rich_rpt
IPR020859ROC_dom
IPR011047Quinoprotein_ADH-like_supfam
IPR011009Kinase-like_dom
IPR027417P-loop_NTPase
Vocabulary: Molecular Function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0005515protein binding
GO:0005525GTP binding
Vocabulary: Biological Process
TermDefinition
GO:0006468protein phosphorylation
GO:0007264small GTPase mediated signal transduction
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006468 protein phosphorylation
biological_process GO:0007264 small GTPase mediated signal transduction
molecular_function GO:0005524 ATP binding
molecular_function GO:0005525 GTP binding
molecular_function GO:0005515 protein binding
molecular_function GO:0004672 protein kinase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 430..450
NoneNo IPR availablePRINTSPR00449RASTRNSFRMNGcoord: 419..432
score: 28.44
coord: 357..379
score: 30.52
coord: 295..316
score: 35.93
NoneNo IPR availableGENE3D1.10.510.10coord: 1159..1381
e-value: 1.9E-37
score: 128.6
NoneNo IPR availableGENE3D3.30.200.20coord: 745..1158
e-value: 1.6E-11
score: 43.8
NoneNo IPR availableGENE3D3.40.50.300coord: 388..501
e-value: 6.7E-5
score: 22.4
NoneNo IPR availableGENE3D3.30.70.1390coord: 293..387
e-value: 6.2E-13
score: 48.0
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1582..1611
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..49
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 1068..1364
e-value: 3.4E-50
score: 182.7
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 1103..1361
e-value: 1.1E-40
score: 139.6
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 1068..1373
score: 35.51
IPR003591Leucine-rich repeat, typical subtypeSMARTSM00369LRR_typ_2coord: 196..218
e-value: 20.0
score: 10.8
coord: 219..243
e-value: 21.0
score: 10.7
coord: 58..80
e-value: 400.0
score: 0.1
coord: 164..186
e-value: 53.0
score: 7.3
IPR015943WD40/YVTN repeat-like-containing domainGENE3D2.130.10.10coord: 1382..1664
e-value: 1.2E-6
score: 27.2
IPR011042Six-bladed beta-propeller, TolB-likeGENE3D2.120.10.30coord: 1665..1837
e-value: 0.033
score: 12.8
IPR032171C-terminal of Roc (COR) domainPFAMPF16095CORcoord: 516..725
e-value: 5.7E-23
score: 81.6
IPR032675Leucine-rich repeat domain, L domain-likeGENE3D3.80.10.10coord: 14..286
e-value: 1.2E-22
score: 79.5
IPR032675Leucine-rich repeat domain, L domain-likeSUPERFAMILY52058L domain-likecoord: 155..264
coord: 62..117
IPR013684Mitochondrial Rho-likePFAMPF08477Roccoord: 338..431
e-value: 2.3E-16
score: 60.0
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 1214..1226
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 221..243
score: 6.672
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 166..187
score: 4.901
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 198..219
score: 7.242
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 59..80
score: 5.517
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 106..127
score: 4.901
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 83..104
score: 7.943
IPR020859Roc domainPROSITEPS51424ROCcoord: 288..500
score: 42.981
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilySUPERFAMILY50998Quinoprotein alcohol dehydrogenase-likecoord: 1405..1529
coord: 1673..1769
IPR011009Protein kinase-like domainSUPERFAMILY56112Protein kinase-like (PK-like)coord: 1055..1369
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILY52540P-loop containing nucleoside triphosphate hydrolasescoord: 295..504

Blast
[Close]
BLAST of TCONS_00052245-protein vs. Swiss-Prot (Human)
Match: LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2 OS=Homo sapiens GN=LRRK2 PE=1 SV=2)

HSP 1 Score: 273.092 bits (697), Expect = 1.841e-73
Identity = 221/754 (29.31%), Postives = 370/754 (49.07%), Query Frame = 0 
Query:   16 HANKKNHRHSYASEPTCFPKRPSWNEESDESDADDEVEI---FKKSGIGRLDVSDNELTVIPPGLPCLAPNLSRLVISKNKITEVDSLSSLPEHLMALDISDNHLKYFN---LMAGKEAEIVN---NICYAL--------VRKHSRNSFPQGKQRKTCLHRKHKQLTELNRLMLNKNSLESL-------QVCLRN----------TDKERPNVLFPDLKILDISHNKLSKVPPGIGRLKNLSSLILSHNNNLTVLPSELGLCNGLYELKIESLHLKDPPKNVIENAMHDGRVDVRSLIGYLKSLHDNAQLYPNIKLMIVGTHGIGKTTLLHALRKEGQGTFKDVDYQCHFNDRRRSQKCLDKGNKSTVGVDVSDWIY----GKKLQIKFSTWDFAGQTEYYATHQCFLSKRALYLVMWRLTDGLDGIDSMQQWLLNIQERAPNCSVIIVGTFLDEA-ENKRKNYVEDMRKEIYKRFVSTKCGGSVPDLAKKGLPKVVQVIEVNSKSQR-SVARVRQLIYDTVVALKANKNSSTSLLETKIPKSYIDVEKAVTKIMDELNSRHDMPVLNEAKFRKKVLEHLTLTGCDLRNGTEELDQAVQFLHDYGILLHYDDPALR--DLYFVDPQWLCDMLAHVVTVRSVN-PFIKNGVLKISDLKSQIFKGEKRFPTDMVMKYVELMSKFEVAIKISEKFLLIPSLLPDKQKECTVIAENESEELRKAMNVNAYLNGSVLRRQYLMSYVPSGFWARLLTRLI 726
            H+NK     SY  + +C       N +   +D    V +    K   + + ++S N+L+ +P  L  +   L +L++  NKI+ + S   L E L  L++S NH+   +   L A  + E  +   N   A+        + K S+N F       +C+      L  L  L ++ N ++ L        + LR            D      L+  ++ L +SHNKL ++PP IG L+NL+SL +S+N  L   P+E+G  + +++L ++ LHL    K++   A        + +I +L+     A  Y  +KLMIVG  G GKTTLL  L K  +    D+  Q                  +TVG+DV DW       +K  +  + WDFAG+ E+Y+TH  F+++RALYL ++ L+ G   +D+M+ WL NI+ RA +  VI+VGT LD + E +RK  +  + KE+               L K+G P +     VN+  +  ++A++R+ I +  +  K         L   IP  Y+++EK +      L+ R ++P+      RK++L+   +    L+    EL  AV FL++ G+LLH+ DPAL+  DLYFV+P+WLC ++A ++TV+    P    G++   D++ +    +++FP + + +Y +L+ KF++A+ I E++LL+PS L D                R  + +    N  ++ R Y M Y P GFW+RL+ RL+
Sbjct: 1043 HSNKFTSFPSYLLKMSCIA-----NLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE-LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKF-------SCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKA--------KDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKS---DLGMQ-----------------SATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKEL---------------LNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQL---IPDCYVELEKII------LSERKNVPIEFPVIDRKRLLQ--LVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVE-KFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDH---------------RPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLL 1713

HSP 2 Score: 122.479 bits (306), Expect = 1.456e-27
Identity = 107/419 (25.54%), Postives = 195/419 (46.54%), Query Frame = 0 
Query: 1023 EEASKLIRDNKPLLCPFHLQLEAKNVFPDLCFMDLDKSHIIAHDQLKEGK----FLGRGSYGDVFMAELTLDNHPNKNQDRHNNQPKTIQVAMKIPMNSEKEKNRKMMATMFSYDTYRNVRQELSILGNINHVNIIRFYGVSVSPFAMLLELAPMGAVDDRYKEYRRVGKRIHPFTIQKSLQ-QISSALKYLHRHHIIYRDLKAENVLVLAFPGPNLVDPIHHQVLLKLTDYGISRSVSLGGIKGFLGTPGFMAPEILRYTGKESYTDKVDCFSFGSLIYELIALHHPFSDVANDKARLAQIYMQNGKRPRLTSKEKRSPVLLLS-LLYRCWAQHPEDRPSAAEINALCSLEEFPKLADTIGLAEDFNFQCVTTTNQSRIDSGVVDSRSVVGSHLWF-CGY--RGFGAAVAARKEGFIT 1432
            EE   L+  ++P      L +    + PDL   DL ++ ++ +D+L+  +     LG GS+G V+ A    +                 +VA+KI                  + + R +RQEL +L +++H ++I      + P  +++ELA  G++D   ++ +    R    T+Q  +   ++  L+YLH   IIYRDLK  NVL+     PN        ++ K+ DYGI++     GIK   GTPGF APE+ R  G   Y  + D +SFG L+Y+++       +         ++ +Q GK P    +   +P  ++  L+ +C  ++P++RP++A++  + +  E   L   I L ++   +C+  T+         +SR+   + +W  CG+  RG  + +    EG+ +
Sbjct: 1835 EEGDLLVNPDQP-----RLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGE-----------------EVAVKI---------------FNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTR----TLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL-YPNAA------IIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQ-GKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH--------NSRN---ASIWLGCGHTDRGQLSFLDLNTEGYTS 2191
The following BLAST results are available for this feature:
BLAST of TCONS_00052245-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
LRRK21.841e-7329.31Leucine-rich repeat serine/threonine-protein kinas... [more]
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