ral GTPase activating protein subunit alpha (polypeptide) - C. hemisphaerica

Overview
Nameral GTPase activating protein subunit alpha
Unique NameTCONS_00004492-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length2252

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00004492-protein ID=TCONS_00004492-protein|Name=ral GTPase activating protein subunit alpha|organism=Clytia hemisphaerica|type=polypeptide|length=2252bp
MSMFHSSKKPGQEKNKNTTKFLDSRRDIHGRLKALRATLELLGDHEIKPF
FGSYSTEIYYVFYEEFTNLEFAGKSKGRQLKEELEELLDLFEKVLVFLPD
LIRSRWQFNSISLILRKLLHHGNVLTIREQGIKLFMIWLQVMQENIDEFN
LAIYASIVPGLANYMARINIPATYRSDKDIKFITSCINGHVNPGSPSLFS
VSIEEDGEWCIPEGCTPICPPQQGEKLPAPEELTKKFLDRILDYMMRPMF
DIQWNQRNMRGSAFYHVFGHFKRFYVPLVFPLWNLTDHLYKESEDIIKVP
LASSSAVSTNTNGYGNNAQLSLTLLQCQTSVIRWLIAFTLQLKSRTFTER
QSESGDSGVPRGSISSESAVINNEDLTSPRITMSSDSGVDSSLRQMGNLY
QAAEIVRSVLYASPDNVLTVYEIYRQCFLMPLTAVDLMSQVLQVFKEWLF
KDEKPLFVLEPKKSVSSLSPTGNLTEWDEMQMIRTPSYKEAVTSSENLFF
SNLPVQNSRAGFQANLRLFIAITGQIFFMKQNKDNVHKHADICKKVMKMY
RSLVLEKNLDKQTWRQLLTVLLDITQHILASRPPESRKSTLGGQLASYLI
QTLFVTWIRASLQVYLAPDLWDHLLLVCSTYTGWQELIKEWNGTMEILTR
VMAKTVYRIDLLDPPLQYLTRKGKVKKNFEGRARNTSNQQSFSTGWGGLN
TQSSGALGRNTSAGANNSPQHLAVKKSSLPRSASEPGIIQKTGKHHLHTL
HSDSCVSSSQSMQVHTTVEELIEHQEEDTDSGLENVDNFNDEHFNDHKKT
LAQIADDTPSTNIMSFDSVASENVFLASSLTSKDFRDSILPPLHSIDKDS
NDSESTNNSLGGISYKQLKEGGPDENEDSGDADDREMDDGQDSDRSSLNI
PVSHSAHSLHSLPGYLSESSQNLLGNDSDESDDNDGIDGNNDVDSEDIEI
ISTKDLDQTIIQFNQNTEQDVNLKPPVNENDSIDTESIQSSGAFTHSEEN
LLDLTLKPKASPHVSVSSDPESMRFDLDLGHKIISDVQSIDSHMFTMLDK
DKSLTMMNSDEVSEQHEGEGTSLTSDEGIQARVRFQDMSNEETSQEDEDR
MNDMTGDSQSLDAFNIETKPRSVIEGGTEVGWTPLSSVILWRRMLGIMGN
INHIKDPEIHATVFKHLIDLWQMLASICKNQGVSLDNKSSPDPPGLTPAL
FFPVSWCFQAMTQEFGGSHKPGRVLAFKLMCMLTTRSHRLKPSTEHIKHF
YRFLHEGLKGSDQNVINAIIGECSSFFTLNFPGASCLINDFIHGTKTIIS
TIYMQYPRKEAVTLLGSLLCFPAAFPSMKIFKLNAMSKQPDDFIRCKDLR
EKILLPLLKAAKNDPSCRARCIALNGLALFVIEVMQHGQNHNRIPECLSV
ILASLDFHSQTVSNVALDVLWSLSYYHDQLQTYDKDIPVKIIESMCLIAL
RLHTTKSSIEEGIPEEKLPEYISRLLLVLLDWVMVTPRDVLLRQRAGNQD
ELKLTYLSLIMRTFKDCIKTYDSNNKFERRQSLNINQMFTGEPRPIQLKR
VHNDLGMDDPQGITDEEDTETDFFMSAKTEQDNKKTILVLTARYCINQVL
NYYLHFPTIGGATCPTSKVHETDDAVHKPSDVGSTPNAPDEQTLLKLYEK
TTMLDSNNMQFLLLNGIALLTVVELPQEEDFLTRSGTEGQKSVCRMIIRD
TTGTHSWEVSNLFKMVQMNDILSQGESTPKRPSFERKHSRNLSVSSARLT
RTATADLPKWDSVDSKVDRIDQLLRYVGQSSPECLIYPDQQLNLPAPVPV
GLDAGIQSLAVTSVLKQHNEEENYIHEIASDARVTASEIQKPSCFDPSSP
FHLSKMLLHQLGYFTWENRKHFELLERNEKLLRQIKNLDKQGSREKHKMA
VFYVAPGQEDKHSILSNSKGSTKFEHFVSQLGWEVDLSTHAGFMGGLERN
LSTGVSAPYYATHSLELIFHVSTRMPGSEEESLKTKLRHLGNDEVHIVWS
EHSRDFRRGIVNTEFGDVLIVIYPMKNDLYRIQIDRHPKIQPFGPLFDGA
IINGDMLANLVRCTAVNAGRANRATLSMYYQHYEERARCIGEISRNCARP
TTFEDFCSKIFAPNLPPSGHTHKDDDGGLHRTFSAPSQSRSNSLKDSAGV
LRFMEMHETQTFRSRTQSALPKNSKPVDHKQVYRTASNTSLQNINEDSNL
LLSPDFCDASGSGDNKDSMSAKERRKSLSKRFRKKAASIDVSGFLMDKTI
GE
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_002531XLOC_002531Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00004492TCONS_00004492Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR000331Rap_GAP_dom
IPR011989ARM-like
IPR016024ARM-type_fold
Vocabulary: Biological Process
TermDefinition
GO:0051056regulation of small GTPase mediated signal transduction
Vocabulary: Molecular Function
TermDefinition
GO:0005096GTPase activator activity
GO:0005488binding
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0051056 regulation of small GTPase mediated signal transduction
molecular_function GO:0005488 binding
molecular_function GO:0005096 GTPase activator activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 1871..1891
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 2118..2145
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..20
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 2211..2230
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 703..736
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 842..945
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1059..1108
IPR000331Rap GTPase activating protein domainPFAMPF02145Rap_GAPcoord: 1914..2088
e-value: 4.0E-43
score: 147.1
IPR000331Rap GTPase activating protein domainPROSITEPS50085RAPGAPcoord: 1885..2093
score: 54.717
IPR000331Rap GTPase activating protein domainSUPERFAMILY111347Rap/Ran-GAPcoord: 1779..2106
IPR011989Armadillo-like helicalGENE3D1.25.10.10coord: 1161..1522
e-value: 2.9E-5
score: 22.5
IPR016024Armadillo-type foldSUPERFAMILY48371ARM repeatcoord: 1204..1427

Blast
BLAST of ral GTPase activating protein subunit alpha vs. Swiss-Prot (Human)
Match: RGPA1 (Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens GN=RALGAPA1 PE=1 SV=1)

HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0
Identity = 400/1026 (38.99%), Postives = 598/1026 (58.28%), Query Frame = 0
Query: 1122 SVIEGGTEVGWTPLSSVILWRRMLGIMGNINHIKDPEIHATVFKHLIDLWQMLASICKNQGVSLDNKSSPDPPGLTPALFFPVSWCFQAMTQEFGGSHKPGRVLAFKLMCMLTTRSHRLKPSTEHIKHFYRFLHEGLKGSDQNVINAIIGECS-SFFTLNFPGASCLINDFIHGTKTIISTIYMQYPRKEAVTLLGSLLCFPAAFPSMKIFKLNAMSKQPDDFI-RCKDLREKILLPLLKAAKNDPSCRARCIALNGLALFVIEVMQHGQNHNRIPECLSVILASLDFHSQTVSNVALDVLWSLSYYHDQLQTYDKDIPVKIIESMCLIALRLHTTKSSIEEGIPEEKLPEYISRLLLVLLDWVMVTPRDVLLR---QRAGNQDELKLTYLSLIMRTFKDCIKTYDSNNKFERRQSLNINQMFTGEPRP-IQLKRVHNDLGMDDPQGITDEEDTETDFFMSAKTEQDNKKTILVLTARYCINQVLNYYLHFPTIGGATCPTSKVHETDDAVHKPSDVGSTPNAPDEQTLLKLYEKTTMLDSNNMQFLLLNGIALLTVVELPQEEDFL---TRSGTEGQKSVCRMIIRDTTGTHSWEVSNLFKMVQMNDI---------LSQGESTPKRPSFERKHSRNLSVS---SARLTRTATADLPKWDSVDSKVDRIDQLLRYVGQSSPECLIYPDQQLNLPAPVPVGLDAGIQSLAVTSVLKQHNEEENYIHEIASDARVTASEIQKPSCFDPSSPFHLSKMLLHQLGYFTWENRKHFELLERNEKLLRQIKNLDKQGSREKHKMAVFYVAPGQEDKHSILSNSKGSTKFEHFVSQLGWEVDLSTHAGFMGGLERNLSTGVSAPYYATHSLELIFHVSTRMPGSEEESLKTKLRHLGNDEVHIVWSEHSRDFRRGIVNTEFGDVLIVIYPMKNDLYRIQIDRHPKIQPFGPLFDGAIINGDMLANLVRCTAVNAGRANRATLSMYYQHYEERARCIGEISRNCARPTTFEDFCSKIFAPNLPPSGHTHKDDD 2126
            SV+ GGT  GW    + ++WRRMLGI+G++N I DPEIHA VF +L +LWQ LA I  N G+S DN +SP PP L P L     W F+A        +K G++ A+KL+C    R   + P+ + + HFY  +H GL   DQ+++N II  CS  FF+L  PGA+ LI DFI     + S+ ++  PR EA  LLGSL+CFP  +  +     N     PD  + +  D++E I+  +L +A+++PS  ARC+AL  L +++ E + H  +H +I E L+VI  SL F ++TV++VA ++L  L +Y  +LQ Y  D P+KII+   LIA   H   S+  E    E     +  LLL LLDW+M  P   LL+         D+ + + L+ I +    C+      +   R   ++++ + + +  P + L+ +     +  P     E  ++       KT+  +   ++ + AR  I  ++N+  H+P  GG    TS+V E  D            N   E T L       + +S N+QF +LN   L++ +++  EE+       +G     S  R+I+RD +G +SW+ + L+    ++ +         LS  E  P+ P    +   +++V    S +  R     +P WD++  + D +D+LL+Y+G +SPECL      LN+PAP PV +    ++  + ++LKQH EE+ ++ +  +D  + A E  +P    P S F+  ++LL  LG  +W+ R+ F LL++NEKLLR+++NLD +  RE HK+AVFYVA GQEDKHSIL+N+ GS  +E FV+ LGWEV+L+ H GFMGGL++N STG++ PY+AT ++E+IFHVSTRMP   ++SL  KLRHLGNDEVHIVWSEH+RD+RRGI+ TEFGDVLIVIYPMKN ++ IQI + P++  FGPLFDGAI+NG +L  +VR TA+NA RA ++ + +Y   YEERAR +  I ++   PTTFEDF +++F+P   P  H   D D
Sbjct: 1046 SVMAGGTLTGWHADVATVMWRRMLGILGDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNLTSPSPPVLIPPLRILTPWLFKATM--LTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHIDQDIVNTIIKHCSPQFFSLGLPGATMLIMDFIVAAGRVASSAFLNAPRVEAQVLLGSLVCFPNLYCELPSLHPNI----PDVAVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEELVHESHHPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYVPRLQIYQPDSPLKIIQ--ILIATITHLLPST--EASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPFHATGAESDKTEKSVLNCIYKVLHGCVYGAQCFSN-PRYFPMSLSDLASVDYDPFMHLESLKEPEPLHSPDS---ERSSKLQPVTEVKTQMQHG--LISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHD------------NHYSESTELS----PELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANSNVRIIVRDLSGKYSWDSAILYGPPPVSGLSEPTSFMLSLSHQEK-PEEPPTSNECLEDITVKDGLSLQFKRFRET-VPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPVCISEKQENDVINAILKQHTEEKEFVEKHFNDLNMKAVEQDEPIPQKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLFDGAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFEDFAAQVFSPA--PYHHLPSDAD 2035          

HSP 2 Score: 374.785 bits (961), Expect = 1.278e-104
Identity = 257/767 (33.51%), Postives = 407/767 (53.06%), Query Frame = 0
Query:    7 SKKPGQEKNKNTTKFLDSRRDIHGRLKALRATLELLGDHEIKPFFGSYSTEIYYVFYEEFTNLEFAGKSKG-RQLKEELEELLDLFEKVLVFLPDLIRSRWQFNSISLILRKLLHHGNVLTIREQGIKLFMIWLQVMQENIDEFNLAIYASIVPGLANYMARINIPATYRSDKDIKFITSCINGHVNPGSPSLFSVSIEEDGEWCIPEGCTPICPPQQGEKLPAPEELTKKFLDRILDYMMRPMFDIQWNQRNMRGSAFYHVFGHFKRFYVPLVFPLWNLTDHLYKESEDIIKVPLASSSAVSTNTNGYGNNAQLSLT--LLQCQTSVIRWLIAFTLQLKSRTFTERQSESGD---SGVPRGS---ISSESAVINNED----LTSPRITMSSDSGV------DSSLRQMGNLYQA-AEIVRSVLYASPDNVLTVYEIYRQCFLMPLTAVDLMSQVLQVFKEWLFKDEKPLFVLEPKKSV---SSLSPTGNLTEWD----------------EMQMIRTPSYKEAVTSSENLFFSNLPV--QNSRAGFQANLRLFIAITGQIFFMK---QNKDNVHKHADICKKVMKMYRSLVLEKNLDKQTWRQLLTVLLDITQHILASRPPES-------RKSTLGGQLASYLIQTLFVTWIRASLQVYLAPDLWDHLLLVCSTYTGWQELIKEWNGTMEILTRVMAKTVYRIDLLDPPLQYLTRKGKVKKNFEGRA---RNTSNQQSFSTGWGGLNTQSSGALGRNTSAGANNSP 719
            SKKP  +  K+T K LD+++D   RLK LR  +E     ++K FF  + + IYYVF+E F  +E + K KG +  +EEL+ +L +FEK+L  LP+ I  RWQF+SI LIL+KLLH GN L IR +G++LF++WLQ +Q N  +  L +++ ++PG           +  +S+   + + + IN  +N        V+IEE          TP+ PPQ G+K    E+LT  FL+ +L Y++  +  ++W  +  +   F  +F HFK++Y+P +FP     + LY    DI ++       V    +   N A        ++ +  VIRWL++F L+ K  T        G+     + R +   +S E +  +N D     T P  + S+ S +       SSL  +   +    EIVR V  +   NV  V EI+RQ FL+P+     M +V++V++EW+ ++EKPLF+ EP++ V   S L    N+T+ D                    +R  S+ +  +    L  ++     QN RAG QA L++FI  +  IF ++   + K+ + +H D+CK+++ +YR +V++ ++DK+TW Q+L VLL +T+ +L   P ++       +  TL G+LA  L QTL V WI+A+L VY++ +LWD LL V S+ T W+EL  EW+ TME LT+V+A+ +Y +DL D PL  L+ + + K   +G     +  S  +SFS GW     Q   A  R  SA    SP
Sbjct:    3 SKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTIEASLKQKGHKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKIRREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGF----------SAPQSEHGPRTLDNLINPPLNLQET---QVTIEE---------ITPLVPPQSGDK--GQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSFLFSHFKKYYLPYIFPNICKENSLYHPILDIPQM-RPKPHYVVIKKDAETNEAIYCTKEPFIKARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDRTTEPEQSHSNTSTLTEREPSSSSLCSIDEEHLTDIEIVRRVFSSKRSNVNFVTEIFRQAFLLPICEAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGEKREEENGTNTADHVRNSSWAKNGSYQGALHNASEEATEQNIRAGTQAVLQVFIINSSNIFLLEPANEIKNLLDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVL-KMPSQAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATEWSLTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWS--RDQPGQAPMRQRSATTTGSP 741          
The following BLAST results are available for this feature:
BLAST of ral GTPase activating protein subunit alpha vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
RGPA11.278e-10438.99Ral GTPase-activating protein subunit alpha-1 OS=H... [more]
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