TCONS_00067656-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00067656-protein
Unique NameTCONS_00067656-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1641

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00067656-protein ID=TCONS_00067656-protein|Name=TCONS_00067656-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1641bp
MLSPSKDVKNVICEDCLQIAVQLNKIEIVNLVCREAPNNMMHCASKALDY
GHHEIALLLLSYTATIHNNHEFLELLFGREPAVEESDCFHQYYSLTLTWS
DIEKLRCYTKNDSVSGMVKNLMFKCSGVKTKLGQKCLKVILLSKKYCCDS
RNKVNWEQLGLTHLEESYINDIANYHKLSLVDNLISHLPWNLEVLVNLTH
LDLSQNKVQEIPVTLLQLPCLRTLNLSCILIESLPQTNKWSPLLKALSLS
GNLLTSLPSKIDSKITYLSIANNKFKEFPMVICNMKTLETLDITGNKDIK
KLPIQLGYNTNLKEIYWEGLNVRDIPIRVHQSRETLLSHMRSKAFQAEPH
YTMKIAVLGQANHGKTTLIRRLLDVSGGNDSLGGENDIDVQELVLSGSNF
TDPRFHFNVWDFAGKEELYVAHKCFLTEDSLNILVFDVTEVQSGVRDIEP
WLVNLASYISKPNVIIIGTKLDRIPKKSFENGFKDYIEGYLKEFIKTFEP
KMRNVNLHIFEVMSLEDREAIKKLRETIYRIAKEMKITPSEKLTLFDHHE
RSKESVMGREIPKSFTIFEREVREKHSILWKPLIHHEDFRYIIRNDFIQE
QLVHYEIDEAIKDLTRFLKAKGTLVHFDCLLDDLDDFYFTDPSWLYQLLC
CAVKILHKTSQHGRMTLHSFKNDLKNEKINFSPLPFKTFLRILYKFQIII
PISADDVLVPSQLYNQPYPMPKQLEFKDMIIRRYVFLLVIPHGFMERLLS
RLVFFMKEMMTEKNLYVDATGSEAVLSNDVTIEKMLVDRSLICWKNGIQL
ELPNFHFSIRKEAVSGIEILETRVLSDPMGYRVLGYIIKHIQTVITEWFS
NFADIRNFAACPVCTRDGCQKVNFINIEDAFLKYNTKMNDNDAQLSCKGQ
HLLSRHDVEKMFPELFFKDLPKDLLIEKSTLHFTESDVFAQGAFGEMYHG
YHTTSKEKLTPVFIKTFNGSNKETNIRELLNAFFTARHETFFLNELQQNP
FIVRLIGISIQTPFLSLVTELASHGTLRDILYNNAGRLPIKRLLLFRIIK
QVANALVYMHQRNIVHRNIRSGSILISELDEQNLTIIVKLGDFEATDSLT
PDGMKKESGAYDFRDPEILLCKGEHDVSVDIYSFSMMIGEMINGRLPFHD
FDRSVLKNGQRPSYENTFAALYGLLPLTDLMTKMCXPSFRGIDPFALKDG
QPPSSYEDTFAALYGLLPLTDLRTKMWKEKGTDRPTAEQTLRQAQDCCFQ
LFYGKKTFPTKVIPLSAVGEKTLWIEYREGLRFIYFGIDMTDLSTSSIAS
NYYADHPNEHLIPFDGHSVAAIVKENDSVYIRVWTASMDSFSQEEQIDCT
IDEVSFYVHRGIIYIAFAQASIILGRVSLDSFTKGRFNKDVSKVNVSGLY
GEEARGKFTSLVVVQPSLELNIIIANGRRLYKTVTFDDSLVLRSSDLTVD
KKLTTSDRITDLILMPCDQKVAIGLSNGVVRIISIDSLVGVVEVKIDQFF
MERYPFEKSTTNLSIVSVCFVLDVMWVGLQNGLILIYDLGEVECPIFLTC
FKPYQERLRRLLLWKVTPVDCLYGVEYLIISIGDQLNSNAFGETGVCQLN
TLFPPRDAKETLKAEHSESTSTILFWQAVDAKAMRIIMQET
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_042246XLOC_042246Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00067656TCONS_00067656Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR003591Leu-rich_rpt_typical-subtyp
IPR013684MIRO-like
IPR032675L_dom-like
IPR000719Prot_kinase_dom
IPR025875Leu-rich_rpt_4
IPR032171COR
IPR015943WD40/YVTN_repeat-like_dom
IPR001611Leu-rich_rpt
IPR020859ROC_dom
IPR017986WD40_repeat_dom
IPR027417P-loop_NTPase
IPR011009Kinase-like_dom
Vocabulary: Biological Process
TermDefinition
GO:0007264small GTPase mediated signal transduction
GO:0006468protein phosphorylation
Vocabulary: Molecular Function
TermDefinition
GO:0005525GTP binding
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0005515protein binding
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006468 protein phosphorylation
biological_process GO:0007264 small GTPase mediated signal transduction
molecular_function GO:0005524 ATP binding
molecular_function GO:0005525 GTP binding
molecular_function GO:0005515 protein binding
molecular_function GO:0004672 protein kinase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003591Leucine-rich repeat, typical subtypeSMARTSM00369LRR_typ_2coord: 242..264
e-value: 45.0
score: 7.9
coord: 195..218
e-value: 0.01
score: 25.0
NoneNo IPR availableGENE3D3.30.200.20coord: 926..1026
e-value: 1.1E-11
score: 44.0
NoneNo IPR availableGENE3D3.40.50.300coord: 342..549
e-value: 7.2E-20
score: 70.5
NoneNo IPR availableGENE3D1.10.510.10coord: 1027..1253
e-value: 1.5E-30
score: 105.8
IPR013684Mitochondrial Rho-likePFAMPF08477Roccoord: 354..472
e-value: 1.5E-17
score: 63.9
IPR032675Leucine-rich repeat domain, L domain-likeGENE3D3.80.10.10coord: 253..341
e-value: 7.7E-14
score: 50.6
IPR032675Leucine-rich repeat domain, L domain-likeGENE3D3.80.10.10coord: 143..252
e-value: 4.5E-13
score: 48.2
IPR032675Leucine-rich repeat domain, L domain-likeSUPERFAMILY52058L domain-likecoord: 111..330
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 940..1242
e-value: 1.5E-28
score: 99.8
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 933..1253
score: 29.814
IPR025875Leucine rich repeat 4PFAMPF12799LRR_4coord: 197..234
e-value: 1.0E-6
score: 28.8
IPR032171C-terminal of Roc (COR) domainPFAMPF16095CORcoord: 605..759
e-value: 2.4E-12
score: 47.0
IPR015943WD40/YVTN repeat-like-containing domainGENE3D2.130.10.10coord: 1291..1566
e-value: 9.3E-5
score: 21.2
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 243..264
score: 7.134
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 220..241
score: 6.002
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 197..219
score: 7.889
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 174..196
score: 6.002
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 287..309
score: 5.34
IPR020859Roc domainPROSITEPS51424ROCcoord: 346..535
score: 31.612
IPR017986WD40-repeat-containing domainSUPERFAMILY50978WD40 repeat-likecoord: 1444..1540
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILY52540P-loop containing nucleoside triphosphate hydrolasescoord: 354..499
IPR011009Protein kinase-like domainSUPERFAMILY56112Protein kinase-like (PK-like)coord: 932..1242

Blast
BLAST of TCONS_00067656-protein vs. Swiss-Prot (Human)
Match: LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2 OS=Homo sapiens GN=LRRK2 PE=1 SV=2)

HSP 1 Score: 277.715 bits (709), Expect = 4.588e-75
Identity = 280/1105 (25.34%), Postives = 504/1105 (45.61%), Query Frame = 0
Query:  124 KCSGVKTKLGQKCLKVILLSKKYCCDSRNKVNWEQLGLTHLEESYINDIANYHKLSLVDNLISHLPWNLEVLVNLTHLDLSQNKVQEIPVTLLQLPCLRTLNLSCILIESLPQTNKWSPL-LKALSLSGNLLTSL----PSKIDSKITYLSIANNKFKEFPMVICNMKTLETLDITGNKDIKKLPIQLGYNTNLKEIYWEGLNVRDIPIRVHQSRETLLSHMRSKAFQAEPHYTMKIAVLGQANHGKTTLIRRLLDVSGGNDSLGGEN-DIDVQELVLSGSNFTDPRFHFNVWDFAGKEELYVAHKCFLTEDSLNILVFDVTEVQSGVRDIEPWLVNLASYISKPNVIIIGTKLDRIPKKSFENGFKDYIEGYLKEFI-KTFEPKMRNVNLHIFEVMSLEDREAIKKLRETIYRIAKEMKITPSEKLTLFDHHERSKESVMGREIPKSFTIFEREV--REKHSILWKPLIHHEDFRYIIRNDFIQEQLVHYEIDEAIKDLTRFLKAKGTLVHFDCLLDDLDDFYFTDPSWLYQLLCCAVKI-LHKTSQHGRMTLHSFKNDLK---NEKINFSPLPFKTFLRILYKFQIIIPISADDVLVPSQLYN-QPYPMPKQLEFKDMIIRRYVFLLVIPHGFMERLLSRLVFFMKEMMTEKNLYVDATGSEAVLSNDVTIEKMLVDRSLICWKNGIQLELPNFHFSIRKEAVSGIEILETR--------VLSDPMGYRVLGYIIKHIQTVITEWFSNFADIRNFAACPVCTRDGCQKVNFINIEDAFLKYN-----TKMNDNDAQLSCKGQHLLSRHD-------VEKMFPELFFKDLPKDLLIEKSTLHFTESDVF--AQGAFGEMYHGYHTTSKEKLTPVFIKTFNGSNKETNIRELLNAFFTARHETFFLNELQQNPFIVRLIGISIQTPFLSLVTELASHGTLRDILYNNAGRLPIKRLLLFRIIKQVANALVYMHQRNIVHRNIRSGSILISELDEQNLTIIVKLGDFEATDSLTPDGMKKESGAYDFRDPEILLCKGEHDVSVDIYSFSMMI-------GEMINGRLPFHDFDRSVLKNGQRPSYENTFAALYGLLPLTDLMTKMC 1185
            K SG+ + L  K LK++ LSK +              ++ L E+++         S   N ++ +P+   +  ++T L LSQNK   IP  +L LP LR+L++S   I+ LP    W  L L+ L  S N ++ L     + + S++  L +++NK KE P  I  ++ L +LD++ N +++  P ++G  + + ++  + L++      +    + ++  ++ +  +A P+  MK+ ++G    GKTTL+++L+     +  +      IDV++  +   +        NVWDFAG+EE Y  H  F+T+ +L + V+D+++ Q+ V  ++PWL N+ +  S   VI++GT LD     S E   K  +    KE + K   P +R+ +     V + E+ +A+ KLR+TI   +   KI                + V+G+ IP  +   E+ +    K+  +  P+I  +    ++R +  Q QL   E+  A+     FL   G L+HF      L D YF +P WL +++   + + +    +H +  +   + D++   ++K  F       + ++L KFQI +PI  + +LVPS L + +P       E  ++IIR Y  +   P GF  RL++RL+     M+         +G E  L  +            + W+ GI L     ++S     + G E+L+          V S   G  +LG ++ HI +++ EWF    +I           D C +   +  + A   +N      K+  +D     +   LL   D       + ++ P+L   DLP+++++    L F ++  F    G+FG +Y   +   +     V +K F   NK T++R L       R E   L  L  +P ++ L+   I+     LV ELAS G+L  +L  +   L   R L  RI   VA+ L Y+H   I++R+++  ++L+  L   N  II K+ D+         G+K   G   FR PE+      ++   D+YSF +++       G ++ G    ++FD   ++ G+ P     +       P+ + + K C
Sbjct: 1118 KISGICSPLRLKELKILNLSKNH--------------ISSLSENFLEACPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLD----VSDEKQRKACMSKITKELLNKRGFPAIRDYHF----VNATEESDALAKLRKTIINESLNFKI--------------RDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN--QLQLDENELPHAV----HFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIIS--RRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYE-MPYFPMGFWSRLINRLLEISPYML---------SGRERALRPN-----------RMYWRQGIYL-----NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEI-----------DICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEE-----VAVKIF---NKHTSLRLL-------RQELVVLCHL-HHPSLISLLAAGIRPRM--LVMELASKGSLDRLLQQDKASL--TRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL-YPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQ-GKLPDPVKEYGC--APWPMVEKLIKQC 2114          
The following BLAST results are available for this feature:
BLAST of TCONS_00067656-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
LRRK24.588e-7525.34Leucine-rich repeat serine/threonine-protein kinas... [more]
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