TCONS_00064881-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00064881-protein
Unique NameTCONS_00064881-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1536

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00064881-protein ID=TCONS_00064881-protein|Name=TCONS_00064881-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1536bp
MKGKQKTNDMRKQGVQRCVIVQRDENGYGLTVSGDNPVFVQSIKEGSAAA
KAGVQVNDQIIKVNGKLVAQSNHLEVVSLIKSGSFVALTLLGKDTNSSNS
STSSRPSSGHTRQRSIGNSIASILSGGNSNPSSPPPDSKSKSDGKVSELK
RMLALEHDVYKRYLEEYMRHPTAKAQQELADSQTRMHSMEQQLKTLTGSI
PPRPSGISIKTNSQRTTSPQSRSSPSPSPIPPQPANAPPQPPHSPPSTDS
TSKSSTPNHDNGSGIKSPKLTKVSQSSSSTSISSTNMTLINESSKSSSKT
PAFPPPDESDGHNFPFAMPQPVADINSAIADTSNSFDALFAQATHDNLNA
GIPLHSAASVISYEEDEFNSEDERFDDHGPFIDLETLKDRPAHLAVFLHF
LMSNNNPVPLLFWLTTDVYAQESGSTKELRKWAYEIYSTFIANNAPLKVM
VSEPEEFAIEESFNPKTSEDRIKGIFDVSRLRIFTEVNEQLADFRNKRAL
GLGGLFGDHQLEDLDRNKEFKVIEQTLVPHLDALMNDSDTDNEQNDRNYA
IAAALTTFLKQVGISKVERYPSFVEKEKGLFSGGFGMNKKKIYKINGHQF
SSTTYTNITMCNFCDKLLWGIAPQGFQCQTCEYNVHKQPCSESLVEMCTG
RKTRPAKGGPRNTVIGAGNSKPDKLLGTVPSMDKDTEGGDQANEKPGEQQ
EQQNADSSDDQENEKATTPGDDSFNYSVTNKAKTIGYKAPKNAKNVKNVG
RSESVKTTKDNVKLSKTKLALPAIKSDFGVYGAAPFKTHAERPDSSPTPE
PDSDNEPDSDLEVETENPNWQSTVVDKKILSKLKSKELKRQEVIHELIHT
ERTHVRNLKVLYRIFYKPLLKENIIPPETVKTIFPNLEELIEIHESLLKP
MKELVKKSEVIDAVGELMLTRFDGEKGLQVKEACATFCRSLSSSLALIKK
LQITKRTVQEFMTRQEANDYCRRLKFSDIMATSHQRLVKYPLLLDQINKS
TPAKHPDYSPVEQCSRCCRDXQINKSTPAKHPDYSPVEQCARCCRDILNH
VNNEIKIVDDKHRLEELSKFIEDKRVLDKDNDGEKEKEGEGKFDISKHKY
VMEGDLTWKVNPQKTLNLHVVLLDDLLVLLQVNDNGKFILKNHNTNMLGT
TGDNKGHSPIIKLTNVIIREVAVDKTAFFMVSTSITGPQIYELVAQSRTE
KIKWTGQINKAAELMKAKDTDRGRRGGLTTSTSIASPAEERRSITKQSSS
VDETQVENLVSPERLQELQNELASSDEELKKLLERRMNIIAEMRGQQSLG
AEKMDEKAPQQPRDIVLAAIAQTKILTESVNAFVLSTKDVSTAEQRNEVT
NSTTTIQGHLTTLLKTMKGGGSSNGKEKGSSHVTRSKSLEKPDRKSSRNA
LKNESSASTSAIIEPVISHARSHSSPAHVLDMNAVGPGMLITSDGNLSSG
GPSANSSTSELPPMKVEHLPLSDETSEAAAHAQQPPQFVSTPPTEQDDGQ
NNLLTNNPSSSSSSSPNETPHQQKLEPAPPIDYFDI
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_040690XLOC_040690Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00064881TCONS_00064881Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR002219PE/DAG-bd
IPR001849PH_domain
IPR000219DH-domain
IPR001478PDZ
IPR015212RGS-like_dom
IPR011993PH_dom-like
IPR016137RGS
Vocabulary: Biological Process
TermDefinition
GO:0035556intracellular signal transduction
GO:0035023regulation of Rho protein signal transduction
Vocabulary: Molecular Function
TermDefinition
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005515protein binding
Vocabulary: Cellular Component
TermDefinition
GO:0005737cytoplasm
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0035556 intracellular signal transduction
biological_process GO:0035023 regulation of Rho protein signal transduction
cellular_component GO:0005737 cytoplasm
molecular_function GO:0005515 protein binding
molecular_function GO:0005089 Rho guanyl-nucleotide exchange factor activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 172..192
NoneNo IPR availableCOILSCoilCoilcoord: 1265..1292
NoneNo IPR availableGENE3D1.10.167.10coord: 408..494
e-value: 1.1E-5
score: 24.9
NoneNo IPR availableGENE3D2.30.42.10coord: 1..109
e-value: 1.3E-19
score: 69.7
NoneNo IPR availableGENE3D1.20.900.10coord: 1022..1082
e-value: 5.3E-7
score: 28.8
NoneNo IPR availableGENE3D1.20.900.10coord: 810..1021
e-value: 3.6E-48
score: 163.3
NoneNo IPR availableGENE3D3.30.60.20coord: 591..658
e-value: 3.1E-15
score: 55.3
NoneNo IPR availableCDDcd00160RhoGEFcoord: 840..1024
e-value: 1.25577E-42
score: 154.763
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 17..91
e-value: 3.7331E-17
score: 77.9922
NoneNo IPR availableSUPERFAMILY57889Cysteine-rich domaincoord: 588..650
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainSMARTSM00109c1_12coord: 598..648
e-value: 1.7E-11
score: 54.2
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainPFAMPF00130C1_1coord: 598..649
e-value: 4.0E-12
score: 45.7
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainPROSITEPS50081ZF_DAG_PE_2coord: 597..648
score: 12.249
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainCDDcd00029C1coord: 598..648
e-value: 8.40095E-14
score: 67.5171
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 1100..1215
e-value: 8.0E-5
score: 32.0
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 1099..1213
score: 7.241
IPR000219Dbl homology (DH) domainSMARTSM00325RhoGEF_3coord: 843..1053
e-value: 1.9E-47
score: 173.6
IPR000219Dbl homology (DH) domainPFAMPF00621RhoGEFcoord: 843..1019
e-value: 2.0E-37
score: 129.1
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 839..1054
score: 30.248
IPR000219Dbl homology (DH) domainSUPERFAMILY48065DBL homology domain (DH-domain)coord: 1022..1073
IPR000219Dbl homology (DH) domainSUPERFAMILY48065DBL homology domain (DH-domain)coord: 822..1020
IPR001478PDZ domainSMARTSM00228pdz_newcoord: 26..94
e-value: 6.8E-18
score: 75.4
IPR001478PDZ domainPFAMPF00595PDZcoord: 22..89
e-value: 8.3E-12
score: 45.2
IPR001478PDZ domainPROSITEPS50106PDZcoord: 18..82
score: 15.26
IPR001478PDZ domainSUPERFAMILY50156PDZ domain-likecoord: 16..95
IPR015212Regulator of G protein signalling-like domainPFAMPF09128RGS-likecoord: 379..564
e-value: 1.8E-46
score: 158.1
IPR011993PH domain-likeGENE3D2.30.29.30coord: 1083..1218
e-value: 2.7E-16
score: 59.4
IPR011993PH domain-likeSUPERFAMILY50729PH domain-likecoord: 1092..1213
IPR016137RGS domainPROSITEPS50132RGScoord: 383..446
score: 10.091
IPR016137RGS domainSUPERFAMILY48097Regulator of G-protein signaling, RGScoord: 378..535

Blast
[Close]
BLAST of TCONS_00064881-protein vs. Swiss-Prot (Human)
Match: ARHGC (Rho guanine nucleotide exchange factor 12 OS=Homo sapiens GN=ARHGEF12 PE=1 SV=1)

HSP 1 Score: 261.922 bits (668), Expect = 1.394e-70
Identity = 163/412 (39.56%), Postives = 247/412 (59.95%), Query Frame = 0 
Query:  812 EVETENPNWQSTVVDKKILSKLKSKELKRQEVIHELIHTERTHVRNLKVLYRIFYKPLLKENIIPPETVKTIFPNLEELIEIHESLLKPMKELVKKSE--VIDAVGELMLTRFDGEKGLQVKEACATFCRSLSSSLALIKKLQITKRTVQEFMTRQEANDYCRRLKFSDIMATSHQRLVKYPLLLDQINKSTPAKHPDYSPVEQCSRCCRDXQINKSTPAKHPDYSPVEQCARCCRDILNHVNNEIKIVDDKHRLEELSKFIEDKRVLDKDNDGEKEKEGEGKFDISKHKYVMEGDLTWKVNPQKTLNLHVVLLDDLLVLLQVNDNGKFILKNHNTNMLGTTGDNK-GHSPIIKLTNVIIREVAVDKTAFFMVSTSITGPQIYELVAQSRTEKIKWTGQINKAAELMKAKDT 1220
            ++ET+ PNWQ  +V +++L  LK  E+KRQEVI+EL +TER HVR LKVL ++FY+ + +E I+ P  ++ IF NLE+++++H  L + MK + K++E  VID +GE +LT F G    ++K A ATFC +   +L +IK  Q      Q F+   E+N  CRRL+  DI+ T  QRL KYPLLLD I     AK+ ++ P E+                       V++ A  CR ILN+VN  +K  ++K RLE+  + ++   +   +    +E       D++K K + EG L WKVN  KT++L+ +LL+D+LVLLQ  D+ + +L+ H + +L +T D+K   SP+IKL+ V++R+VA D  A F++S S  G QIYELVAQ+ +EK  W   I + A  +K + T
Sbjct:  761 DLETDPPNWQQ-LVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNI-----AKYTEW-PTER---------------------EKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRN---LDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD-RLVLRCH-SKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQST 1139

HSP 2 Score: 145.976 bits (367), Expect = 7.199e-35
Identity = 94/220 (42.73%), Postives = 129/220 (58.64%), Query Frame = 0 
Query:   15 VQRCVIVQRDENGYGLTVSGDNPVFVQSIKEGSAAAKAGVQVNDQIIKVNGKLVAQSNHLEVVSLIKSGSFVALTLLGKDTNSSN---SSTSSRPSS-GHTRQRSIGNSIASILSGGNSNPSSPP----PDSKSKSDGKVSELKRMLALEHDVYKRYLEEYMRHPTAKAQQELADSQTRMHSMEQQLKTLTGS-------IPPRPSGISIKTNSQRTTSP 219
            VQRCVI+Q+D+NG+GLTVSGDNPVFVQS+KE  AA +AGVQ  D+IIKVNG LV  SNHLEVV LIKSGS+VALT+ G+   S     + +   PS  GH     I  S  S  + GN    + P     ++    + KV  L++ML  E +  +   E+Y R P  +  +E+ +++  +  +++QL   TGS        P RP G ++ T S+  T P
Sbjct:   69 VQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHM--SPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTL-TVSEAETDP 285

HSP 3 Score: 92.8189 bits (229), Expect = 1.102e-18
Identity = 67/232 (28.88%), Postives = 117/232 (50.43%), Query Frame = 0 
Query:  357 AASVISYEEDEFNSEDERFDDH-GPFIDLETLKDRPAHLAVFLHFLMSNNNPVPLLFWLTTDVYAQESGSTKELRKWAYEIYSTFIANNAPLKVMVSEPEEFAIEESFNPKTSEDRIKGIFDVSRLRIFTEVNEQLADFRNKRALGLGGLFGDHQLEDLD--RNKEFKVIE------QTLVPHLDALMNDSDTDNEQNDRNYAIAAALTTFLKQVGISKVERYPSFVEKEKG 579
            A  +I  E+D+F +E E+ +     F  +E LK RPAHLAVFLH ++S  +P  LL +L +D+Y     ++KE R+   E +  F+  +A LKV V +     +E+       ED  +      + R+  EV   L DFR KR++GL     + +L  LD  R+K+   +E      + +V  ++ ++  +    E  D++  +   +  ++K +G+   E  P  +E ++G
Sbjct:  347 APHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKH--TNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGL--TLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEE--DKSSTMQYVILMYMKHLGVKVKE--PRNLEHKRG 570
The following BLAST results are available for this feature:
BLAST of TCONS_00064881-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
ARHGC1.394e-7039.56Rho guanine nucleotide exchange factor 12 OS=Homo ... [more]
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