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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00060889-protein ID=TCONS_00060889-protein|Name=Rho GTPase subfamily member|organism=Clytia hemisphaerica|type=polypeptide|length=1204bp
MIENDPSEHLTLPKPPKPAQSHHNNRPLHKNNNAEDENDPELQVIREFLN
TANLDSSGFIDETELAAVVDLSPDEIRQIFWTLDNDGDGKISIEQFTHYY
KTLQEKQDVNENELPPADNAKPMPAHHQDMTRDSFRDSGYSMSEPTHRKK
KHPTTLSPKTQKDAAKYLGQEYLDDLYEVARSRDDPLLLESLENFLSATV
DNLLKKQADNERLDAALKHAKDQNTEIAAQIEDEMEEQVAIMEEKIRQEE
EQKLTQQKQEAHAQLQKANDELGDMEHKIIALEEKLNEQKIKEASIPDHF
IDKIQRKEQENQQLQAKLLEFHTQMSLMRTEVAALKSEYDEQSSRLHNER
GTVLSCVREQENLTRQLQMLHEANKRLHDTNDDLRSALDVKRSNSFMNES
SISPLKRSQSFAHQQNPLFKHDLQSSFRSDPGYARHHSTLNNTDFNDTDD
DSRQSFSRDDDVIDDLIDNDDVINQQSLMAELMSAEDQAFDHPPRRRTGS
ALSNLSGSNLSNISEREQFAQQLEMLAETNRRLGESNDDLRNALSLLTDH
VRSQSVSERSEGPLSRRDGSERSDILTSRRESPPGCYSTPSTPLKSEYTE
RPRPNSTSSPRKVILTKSGYHSQSDTSTAEDTTTNVVSNDDQTLAQTKET
SSFCTTCDGDTKSGLTNCPTCGEGDAPEDTAHILENVSWDETPPFSLRPD
TPISGRDRKNSVLSNQSNQSPSTSKIPTPRSMNSPRFRSGTLKSSPRTPL
RSGRSSLQNSPRVEDPLKPFGSGSSKSSPRTPLRSGRSSLKNSPRIEDPI
RAIRENNLESGLRPLLQEEDLIEPSEIALDESSAPETTTDDFFRKLEDIP
PSVCETCDQTIQVDFTGTEQCQCTLNERDRLLDTLLTDSDSDDSYTEQET
SHLGIRHRVQKPPLSSDNQMSMLSTSEISEDELENSDNDSVDDEELIRLV
DQAANEETGSITDEPITVEEKILDVETVPRGPGVGADTSSESGASVGDVS
SEPDEMFKLVLAGNAAVGKSSFILRLCKNKFYSALNATLGVDFQMKRMIV
DKKKIALQCWDTAGQERFRSIAKSYFRRVDGVVLLYDVTCENSFLDVREW
IESIESSSDNVPVILCGNKVDLRPDAERIGMPVISRDQGQQLAKDVGALF
IETSAKEGTNIHRACKDLIRMMQRNENPKPHPNGTVQLDPESEKPKKAGC
CGKS Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0005509 | calcium ion binding |
| GO:0005525 | GTP binding |
| GO:0003924 | GTPase activity |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| molecular_function |
GO:0005509 |
calcium ion binding |
| molecular_function |
GO:0003924 |
GTPase activity |
| molecular_function |
GO:0005525 |
GTP binding |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| None | No IPR available | COILS | Coil | Coil | coord: 523..543 |
| None | No IPR available | COILS | Coil | Coil | coord: 304..324 |
| None | No IPR available | COILS | Coil | Coil | coord: 203..292 |
| None | No IPR available | PRINTS | PR00449 | RASTRNSFRMNG | coord: 1030..1046
score: 26.42
coord: 1150..1172
score: 34.22
coord: 1048..1070
score: 49.33
coord: 1007..1028
score: 40.83
coord: 1109..1122
score: 54.1 |
| None | No IPR available | SMART | SM00174 | rho_sub_3 | coord: 1009..1175
e-value: 1.1E-12
score: 42.6 |
| None | No IPR available | SMART | SM00173 | ras_sub_4 | coord: 1004..1175
e-value: 5.8E-24
score: 95.6 |
| None | No IPR available | SMART | SM00175 | rab_sub_5 | coord: 1007..1175
e-value: 2.9E-61
score: 219.5 |
| None | No IPR available | SMART | SM00176 | ran_sub_2 | coord: 1012..1202
e-value: 1.9E-4
score: 14.4 |
| None | No IPR available | GENE3D | 3.30.70.1390 | | coord: 1005..1070
e-value: 7.1E-24
score: 83.1 |
| None | No IPR available | GENE3D | 1.20.5.340 | | coord: 297..404
e-value: 7.3E-6
score: 25.3 |
| None | No IPR available | GENE3D | 3.40.50.300 | | coord: 1071..1173
e-value: 1.3E-30
score: 104.9 |
| None | No IPR available | GENE3D | 1.10.238.10 | | coord: 16..88
e-value: 5.9E-10
score: 38.7 |
| None | No IPR available | GENE3D | 1.10.238.10 | | coord: 89..294
e-value: 3.8E-5
score: 23.3 |
| None | No IPR available | GENE3D | 1.20.5.400 | | coord: 437..549
e-value: 0.15
score: 11.6 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1174..1204 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 979..1000 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 686..801 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1..39 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 490..509 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 887..942 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 423..457 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 551..633 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 112..160 |
| None | No IPR available | PROSITE | PS51419 | RAB | coord: 1002..1201
score: 30.512 |
| None | No IPR available | CDD | cd00154 | Rab | coord: 1007..1170
e-value: 2.12662E-66
score: 220.79 |
| IPR002048 | EF-hand domain | SMART | SM00054 | efh_1 | coord: 44..72
e-value: 22.0
score: 6.9
coord: 75..103
e-value: 0.18
score: 20.9 |
| IPR002048 | EF-hand domain | PROSITE | PS50222 | EF_HAND_2 | coord: 71..106
score: 11.25 |
| IPR002048 | EF-hand domain | CDD | cd00051 | EFh | coord: 55..98
e-value: 5.97846E-6
score: 44.4609 |
| IPR001806 | Small GTPase superfamily | PFAM | PF00071 | Ras | coord: 1008..1172
e-value: 3.7E-47
score: 159.8 |
| IPR005225 | Small GTP-binding protein domain | TIGRFAM | TIGR00231 | TIGR00231 | coord: 1006..1165
e-value: 2.7E-24
score: 83.8 |
| IPR011992 | EF-hand domain pair | SUPERFAMILY | 47473 | EF-hand | coord: 42..108 |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase | SUPERFAMILY | 52540 | P-loop containing nucleoside triphosphate hydrolases | coord: 1003..1180 |
Blast
BLAST of Rho GTPase subfamily member vs. Swiss-Prot (Human)
Match: RASEF (Ras and EF-hand domain-containing protein OS=Homo sapiens GN=RASEF PE=1 SV=1) HSP 1 Score: 216.468 bits (550), Expect = 1.010e-58 Identity = 105/197 (53.30%), Postives = 140/197 (71.07%), Query Frame = 0
Query: 1007 FKLVLAGNAAVGKSSFILRLCKNKFYSALNATLGVDFQMKRMIVDKKKIALQCWDTAGQERFRSIAKSYFRRVDGVVLLYDVTCENSFLDVREWIESIESSS-DNVPVILCGNKVDLRPDAERIGMPVISRDQGQQLAKDVGALFIETSAKEGTNIHRACKDLIRMMQRNENPKPHPNGTVQLDPESEK-PKKAGCC 1201
+K+VLAG+AAVGKSSF++RLCKN+F ++ATLGVDFQMK +IVD ++ LQ WDTAGQERFRSIAKSYFR+ DGV+LLYDVTCE SFL++REW++ IE ++ + VP++L GNK D+R A G + G++LA GALF ETSAK+G+NI A L R +++ + + T S+K P+ CC
Sbjct: 542 YKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCC 738 HSP 2 Score: 98.9821 bits (245), Expect = 5.581e-21 Identity = 103/405 (25.43%), Postives = 202/405 (49.88%), Query Frame = 0
Query: 36 DENDPELQVIREFLNTANLDSSGFIDETELAAV---VDLSPDEIRQIFWTLDNDGDGKISIEQFTH-YYKTLQEKQDVNENELPPADN-AKPMPAHHQDMTRDSFRDSGYSMS------EPTHRKKKHPTTLSPKTQKDAAKYL-GQEYLDDLYEVARSRDDPLLLESLENFLSATVDNLLKKQADNERLDAALKHAKDQNTEIAAQIEDEMEEQVAIMEEKIRQEEEQKLTQQKQEAHAQLQKAND-ELGDMEHKIIALEEKLNEQKIKEASIPD--HFIDKIQRKEQENQQLQAKLLEFHTQMSLMRTEVAALKSEYDEQSSRLHNERGTVLSCVREQENLTRQLQMLHEANKRLHDTNDDLRSALD--VKRSNSFMNESSISP---LKRS--QSFAHQQNPL 418
D + EL +R + + SG ++ E A+ + + P + +F LD D DG I+ ++F + +L+ + + L PA ++ P H + D+ +++ P + L D AK++ +E + LY+ + +P L++ E+ + + + + + E L A+K A+D+ +++E+EM++++ E K R++E++K +EA + L++ + E+GD++ I L KL EQ + + D +I ENQ+++ LLE T ++ +++E+ ALKS+Y +QS + + + ++ +L RQ+++L AN++LHD+ND LRSAL+ + N ++ ++ISP + RS + H PL
Sbjct: 4 DGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCGPASPGRAWQDFQARLG-----DEAKFIPREEQVSTLYQNI-NLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRK----AEEALSDLRRQYETEVGDLQVTIKKLR-KLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPL 397
The following BLAST results are available for this feature:
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