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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00060554-protein ID=TCONS_00060554-protein|Name=TCONS_00060554-protein|organism=Clytia hemisphaerica|type=polypeptide|length=475bp MLRVSQRLMAPVKKFDYLVVGGGSGGIASARRATEFCKSDGSKLKVAVIE EKRLGGTCVNVGCVPKKVMFNTALHAEMLHDMKDYGFDVTYNGFDWSHVK TKRDAYVKRLNGMFATNLDKAEVEHIDGHAKFDSDGVCHVGDLQLQGEHT MIATGGKPLVPNVPGAEYGITSDGFFELEKLPKKTVVVGAGYIAVELAAI LQTLGSEVHHFIRNDKVLRNFDSLISESITNEHENNVGVKLHKFVDSKSM KITKCDNTGLLSIETLAGPNKETLQINDAECLLWAVGRVPNTTDLGLEGL GIKMNEKQEIVVDEFQNTSKPNFYALGDVCGKALLTPVAIAAGRRLSHRL FNNELDSKLNYDNIPTVVFSHPTIGTIGLTEREAREKYGEENIKIYQSKF TNMFYTFAENKPQTVLKLVCQLPTEKVVGLHCMGMGCDEMLQGFSVAVKM GATKKDFDNTVAIHPTSSEEFVTMR Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
Term | Definition |
GO:0050661 | NADP binding |
GO:0004362 | glutathione-disulfide reductase activity |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0016491 | oxidoreductase activity |
GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
Vocabulary: Biological Process
Term | Definition |
GO:0055114 | oxidation-reduction process |
GO:0006749 | glutathione metabolic process |
GO:0045454 | cell redox homeostasis |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category |
Term Accession |
Term Name |
biological_process |
GO:0045454 |
cell redox homeostasis |
biological_process |
GO:0006749 |
glutathione metabolic process |
biological_process |
GO:0055114 |
oxidation-reduction process |
molecular_function |
GO:0050660 |
flavin adenine dinucleotide binding |
molecular_function |
GO:0004362 |
glutathione-disulfide reductase activity |
molecular_function |
GO:0050661 |
NADP binding |
molecular_function |
GO:0016491 |
oxidoreductase activity |
molecular_function |
GO:0016668 |
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
None | No IPR available | PRINTS | PR00368 | FADPNR | coord: 147..165 score: 28.19 coord: 17..36 score: 35.72 coord: 279..295 score: 38.28 coord: 184..202 score: 40.55 coord: 308..330 score: 36.63 |
None | No IPR available | PRINTS | PR00411 | PNDRDTASEI | coord: 54..69 score: 70.89 coord: 184..209 score: 44.31 coord: 449..469 score: 41.32 coord: 280..294 score: 44.51 coord: 323..330 score: 54.04 coord: 427..442 score: 30.51 coord: 16..38 score: 38.45 coord: 360..381 score: 42.74 coord: 150..159 score: 43.82 |
None | No IPR available | GENE3D | 1.10.287.990 | | coord: 53..120 e-value: 8.2E-23 score: 80.3 |
None | No IPR available | PIRSF | PIRSF000350 | Hg-II_reductase_MerA | coord: 3..471 e-value: 3.8E-72 score: 241.6 |
None | No IPR available | SFLD | SFLDF00172 | glutathione_reductase | coord: 9..475 e-value: 0.0 score: 606.2 |
IPR006322 | Glutathione reductase, eukaryote/bacterial | TIGRFAM | TIGR01421 | TIGR01421 | coord: 13..475 e-value: 1.9E-197 score: 654.9 |
IPR023753 | FAD/NAD(P)-binding domain | PFAM | PF07992 | Pyr_redox_2 | coord: 15..343 e-value: 3.2E-55 score: 187.4 |
IPR023753 | FAD/NAD(P)-binding domain | GENE3D | 3.50.50.60 | | coord: 130..243 e-value: 9.7E-20 score: 70.3 |
IPR023753 | FAD/NAD(P)-binding domain | GENE3D | 3.50.50.60 | | coord: 244..362 e-value: 1.7E-12 score: 47.1 |
IPR023753 | FAD/NAD(P)-binding domain | SUPERFAMILY | 51905 | FAD/NAD(P)-binding domain | coord: 13..389 |
IPR004099 | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | PFAM | PF02852 | Pyr_redox_dim | coord: 364..474 e-value: 4.0E-35 score: 120.3 |
IPR016156 | FAD/NAD-linked reductase, dimerisation domain | GENE3D | 3.30.390.30 | | coord: 363..475 e-value: 1.0E-38 score: 131.8 |
IPR016156 | FAD/NAD-linked reductase, dimerisation domain | SUPERFAMILY | 55424 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | coord: 361..475 |
IPR012999 | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | PROSITE | PS00076 | PYRIDINE_REDOX_1 | coord: 55..65 |
Blast
BLAST of TCONS_00060554-protein vs. Swiss-Prot (Human)
Match: GSHR (Glutathione reductase, mitochondrial OS=Homo sapiens GN=GSR PE=1 SV=2) HSP 1 Score: 521.546 bits (1342), Expect = 0.000e+0 Identity = 273/471 (57.96%), Postives = 336/471 (71.34%), Query Frame = 0
Query: 12 VKKFDYLVVGGGSGGIASARRATEFCKSDGSKLKVAVIEEKRLGGTCVNVGCVPKKVMFNTALHAEMLHDMKDYGFDVTYNGFDWSHVKTKRDAYVKRLNGMFATNLDKAEVEHIDGHAKFDSDG--VCHVGDLQLQGEHTMIATGGKPLVPN---VPGAEYGITSDGFFELEKLPKKTVVVGAGYIAVELAAILQTLGSEVHHFIRNDKVLRNFDSLISESITNEHENNVGVKLHKFVDSKSMKITKCDNTGLLSIETLAGPNKETLQ--INDAECLLWAVGRVPNTTDLGLEGLGIKMNEKQEIVVDEFQNTSKPNFYALGDVCGKALLTPVAIAAGRRLSHRLFNNELDSKLNYDNIPTVVFSHPTIGTIGLTEREAREKYGEENIKIYQSKFTNMFYTFAENKPQTVLKLVCQLPTEKVVGLHCMGMGCDEMLQGFSVAVKMGATKKDFDNTVAIHPTSSEEFVTMR 475
V +DYLV+GGGSGG+ASARRA E + AV+E +LGGTCVNVGCVPKKVM+NTA+H+E +HD DYGF F+W +K KRDAYV RLN ++ NL K+ +E I GHA F SD V + H +IATGG P P+ +PGA GITSDGFF+LE+LP ++V+VGAGYIAVE+A IL LGS+ IR+DKVLR+FDS+IS + T E EN GV++ KF K +K T +GL A P + + I D +CLLWA+GRVPNT DL L LGI+ ++K I+VDEFQNT+ YA+GDVCGKALLTPVAIAAGR+L+HRLF + DSKL+Y+NIPTVVFSHP IGT+GLTE EA KYG EN+K Y + FT M++ + K + V+K+VC EKVVG+H G+GCDEMLQGF+VAVKMGATK DFDNTVAIHPTSSEE VT+R
Sbjct: 62 VASYDYLVIGGGSGGLASARRAAEL------GARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELEN-AGVEVLKFSQVKEVKKTL---SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522
The following BLAST results are available for this feature:
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