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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00047677-protein ID=TCONS_00047677-protein|Name=TCONS_00047677-protein|organism=Clytia hemisphaerica|type=polypeptide|length=700bp MSTRKVYSSQGKSSYHLGGAHKDISANAKPSDSVPHNGVSYDDLKKHCLK QGVLFEDPDFPAVDQSMFFSRKPPRPFVWKRPKELVSDPKMFVGGASRFD ITQGMLGDCWLLAAVAALCQYEGLLYQVVPPDQSFSSSDYCGIVRFRFWQ YGRWEEVVVDDRLPTYNNKLVFLHSAQNNEFWSALLEKAYAKLCGSYESL KGGQTSEAMEDFTGGVTETFNTAKPPAKFYSLLMKAQERQSLMCCSIEAK PNEIEAKLNNGLIKGHAYTITSVQKAHVRGQEIELIRIRNPWGNEREWTG AWSDGSNEWKMLSDSEKKELGISYDDDGEFWMSFQDFCANYTKVEVCMLS PDSAGESDKKRWEMQINQGTWQQHVSAGGCRNFPDSFHLNPQYIVKLEDG DDDDDNCTIVIGLIQKGRRKQKRVGAQNLTIGFSVYKLDDDKDEYMQDDR LSKDFFLYHKSHARSHNFVNSREVTGRFSFEPGEYVIIPSTFKANEEGDF IMRMFSEKAHAGGSMDTKTQIEYKPKVLSQSEKDSFDSKFKPFFEKVAGN DGEIDAFELQAVLNSAFKKEMNGKSFSLEACRSMVAMVDRDRNGKLDYEE FRTMWTTVMRYKANFAQYDKDQSGDMSATELRDALAKLGFKLSTPVLSSL TLRYANKKGQVNIDDYLQICCRVKSSFESYLSYQGKSFSLDDYIMSAVYT Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Cellular Component
Term | Definition |
GO:0005622 | intracellular |
Vocabulary: Biological Process
Term | Definition |
GO:0006508 | proteolysis |
Vocabulary: Molecular Function
Term | Definition |
GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
GO:0005509 | calcium ion binding |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category |
Term Accession |
Term Name |
biological_process |
GO:0006508 |
proteolysis |
cellular_component |
GO:0005622 |
intracellular |
molecular_function |
GO:0004198 |
calcium-dependent cysteine-type endopeptidase activity |
molecular_function |
GO:0005509 |
calcium ion binding |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
IPR022684 | Peptidase C2, calpain family | PRINTS | PR00704 | CALPAIN | coord: 140..165 score: 64.1 coord: 170..193 score: 78.75 coord: 103..119 score: 69.02 coord: 326..347 score: 59.39 coord: 479..507 score: 52.64 coord: 39..62 score: 47.08 coord: 195..222 score: 64.05 coord: 79..101 score: 55.07 coord: 376..393 score: 67.04 |
IPR022683 | Peptidase C2, calpain, domain III | SMART | SM00720 | 2cal | coord: 361..513 e-value: 1.2E-65 score: 234.1 |
IPR002048 | EF-hand domain | SMART | SM00054 | efh_1 | coord: 610..638 e-value: 1.3 score: 16.9 coord: 580..608 e-value: 0.0099 score: 25.1 |
IPR002048 | EF-hand domain | PFAM | PF13833 | EF-hand_8 | coord: 551..606 e-value: 2.7E-8 score: 33.4 |
IPR002048 | EF-hand domain | PROSITE | PS50222 | EF_HAND_2 | coord: 550..569 score: 5.726 |
IPR002048 | EF-hand domain | PROSITE | PS50222 | EF_HAND_2 | coord: 576..611 score: 12.17 |
IPR002048 | EF-hand domain | PROSITE | PS50222 | EF_HAND_2 | coord: 615..641 score: 10.078 |
IPR002048 | EF-hand domain | CDD | cd00051 | EFh | coord: 550..606 e-value: 3.05306E-8 score: 50.2389 |
IPR001300 | Peptidase C2, calpain, catalytic domain | SMART | SM00230 | cys_prot_2 | coord: 36..359 e-value: 8.6E-172 score: 586.7 |
IPR001300 | Peptidase C2, calpain, catalytic domain | PFAM | PF00648 | Peptidase_C2 | coord: 55..347 e-value: 6.3E-127 score: 422.6 |
IPR001300 | Peptidase C2, calpain, catalytic domain | PROSITE | PS50203 | CALPAIN_CAT | coord: 54..350 score: 77.521 |
IPR001300 | Peptidase C2, calpain, catalytic domain | CDD | cd00044 | CysPc | coord: 44..347 e-value: 3.57935E-138 score: 410.184 |
None | No IPR available | GENE3D | 1.10.238.10 | | coord: 595..624 e-value: 1.1E-11 score: 43.8 |
None | No IPR available | GENE3D | 3.90.70.10 | | coord: 215..360 e-value: 3.8E-54 score: 181.6 |
None | No IPR available | GENE3D | 2.60.120.380 | | coord: 361..508 e-value: 3.1E-43 score: 146.9 |
None | No IPR available | GENE3D | 1.10.238.10 | | coord: 625..680 e-value: 1.7E-8 score: 34.0 |
None | No IPR available | GENE3D | 1.10.238.10 | | coord: 552..594 e-value: 9.4E-11 score: 41.2 |
None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1..36 |
None | No IPR available | SUPERFAMILY | 54001 | Cysteine proteinases | coord: 33..354 |
IPR022682 | Peptidase C2, calpain, large subunit, domain III | PFAM | PF01067 | Calpain_III | coord: 369..509 e-value: 9.1E-47 score: 158.8 |
IPR022682 | Peptidase C2, calpain, large subunit, domain III | SUPERFAMILY | 49758 | Calpain large subunit, middle domain (domain III) | coord: 362..509 |
IPR018247 | EF-Hand 1, calcium-binding site | PROSITE | PS00018 | EF_HAND_1 | coord: 589..601 |
IPR018247 | EF-Hand 1, calcium-binding site | PROSITE | PS00018 | EF_HAND_1 | coord: 619..631 |
IPR000169 | Cysteine peptidase, cysteine active site | PROSITE | PS00139 | THIOL_PROTEASE_CYS | coord: 103..114 |
IPR033883 | Calpain subdomain III | CDD | cd00214 | Calpain_III | coord: 360..508 e-value: 5.83875E-58 score: 192.899 |
IPR011992 | EF-hand domain pair | SUPERFAMILY | 47473 | EF-hand | coord: 537..681 |
Blast
BLAST of TCONS_00047677-protein vs. Swiss-Prot (Human)
Match: CAN9 (Calpain-9 OS=Homo sapiens GN=CAPN9 PE=1 SV=1) HSP 1 Score: 640.188 bits (1650), Expect = 0.000e+0 Identity = 317/672 (47.17%), Postives = 455/672 (67.71%), Query Frame = 0
Query: 26 ANAKPSDS-VPHN-GVSYDDLKKHCLKQGVLFEDPDFPAVDQSMFFSRKPPRPFVWKRPKELVSDPKMFVGGASRFDITQGMLGDCWLLAAVAALCQYEGLLYQVVPPDQSFSSSDYCGIVRFRFWQYGRWEEVVVDDRLPTYNNKLVFLHSAQNNEFWSALLEKAYAKLCGSYESLKGGQTSEAMEDFTGGVTETFNTAKPPAKFYSLLMKAQERQSLMCCSIEAK-PNEIEAKLNNGLIKGHAYTITSVQKAHVRGQEIELIRIRNPWGNEREWTGAWSDGSNEWKMLSDSEKKELGISYDDDGEFWMSFQDFCANYTKVEVCMLSPDSAGESDKKRWEMQINQGTWQQHVSAGGCRNFPDSFHLNPQYIVKLEDGDDDDDNCTIVIGLIQKGRRKQKRVGAQNLTIGFSVYKLDDDKDEYMQDDRLSKDFFLYHKSHARSHNFVNSREVTGRFSFEPGEYVIIPSTFKANEEGDFIMRMFSEKAHAGGSMDTKTQIEYKPKVLSQS--EKDSFDSKFKPFFEKVAGNDGEIDAFELQAVLNSAFK--KEMNGKSFSLEACRSMVAMVDRDRNGKLDYEEFRTMWTTVMRYKANFAQYDKDQSGDMSATELRDALAKLGFKLSTPVLSSLTLRYANKKGQVNIDDYLQICCRVKSSFESY--LSYQGKSF 688
A+ P D+ + H+ G S++ +++ CL++G LFED DFPA + S+F+S +P PFVWKRP E+V +P+ +GGA+R DI QG LGDCWLLAA+A+L + L +V+P DQSF Y GI F+FWQ+ W +VV+DDRLPT+ ++LVFLHSA +NEFWSALLEKAYAKL GSYE+LKGG EAMEDFTGGV ETF T + P FY +L KA +R SL+ C I+ + E EA+ GLIKGHAY++T + + RGQ IELIRIRNPWG + EW G+WSD S EW+ + +E+K L + DDGEFWM+F+DF A++ KVE+C L+PD+ E +WE+ ++QG+W + +AGGCRNF D+F NPQ + L + D+ + C+ ++ L+QK RRK KR GA LTIG+++Y+ D +D+ L+KDFF YH S ARS F+N REV+ RF PGEY++IPSTF+ ++E DF +R+FSEK MD I+ ++ + +F+ FE+VAG D E+ A EL+ VLN+ + K++ K SL +C+++++++D NGKL+++EF+ W + ++ F ++D D+SG MS ELR AL GF+LS+ +L + LRYA+++ Q++ DD+L R++++ + LS + K F
Sbjct: 12 AHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPG-YAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWG-QVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD------KDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEF 675
The following BLAST results are available for this feature:
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