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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00019329-protein ID=TCONS_00019329-protein|Name=TCONS_00019329-protein|organism=Clytia hemisphaerica|type=polypeptide|length=783bp
MMSLLVQHLVRFSHQKYLEVLLISVSTFLALFTRICAVDGKWNLQSENKL
VWLVAYDIVVFNVSIMHAFIQVSRVVHKTLASGKHIILLNLLFYCIANLV
CFFCIGLALFEDSSCMFRFGLSTMLFVFDWDLWGKFSRNLLLVLSKVSTS
EELIKKECILAEEILFKSFTKMVIITVPYYLGVAEFSVLCQITCLAILVN
SLTFITMLPAIINMQIHLYEKKYSSVNGRETQIYAETFLREIDELQSAKG
QFLSPLFLSSISIHVFNLVMIVVDSDIQEFVKKNIIAVLPDTSSLIPEQV
YMSVVIFMLAYKYLLHEMKKSIQHKPKFNNMANCNVQVPPPTTQHRIKET
EDLVNLSNEEILQLCKEKKLALHSLEATLNDHKRAVEIRRSFVTAEIGKE
ADALDDLPYENYNYEKVYGVCCENVIGYCTVPLGVAGPLLLDNNKFYVPM
ATTEGCLVASTNRGCSALRASGGVFSYLIGDGMTRGPVVRMTSAREACLV
REWIEEQDNFIILSEAFNQSSRFTELLEIKCAMAGKLLFLRFKASTGDAM
GMNMVSKGTEHALKYLKIQFPSMEVVSLSGNYCTDKKPSAINWIDGRGKG
VICEATIPGEIVRKTLKTNPEALIEVNISKNLIGSALAGSIGGQNAHAAN
IVAAIFIATGQDPAQTVVSSNCITVMELAGENMTDLYISCTMPSIETGTI
GGGTSLPSQKSALKLLGLDEIRGMPGKNSQQLARVICGTVLAGELSLLSA
LASNHLVKSHMKLNRQSTPSLTGDKPTTTCPVL Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0055114 | oxidation-reduction process |
| GO:0015936 | coenzyme A metabolic process |
| GO:0008299 | isoprenoid biosynthetic process |
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| GO:0050662 | coenzyme binding |
| GO:0050661 | NADP binding |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Vocabulary: Cellular Component
| Term | Definition |
|---|
| GO:0016021 | integral component of membrane |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0015936 |
coenzyme A metabolic process |
| biological_process |
GO:0008299 |
isoprenoid biosynthetic process |
| biological_process |
GO:0055114 |
oxidation-reduction process |
| cellular_component |
GO:0016021 |
integral component of membrane |
| molecular_function |
GO:0050662 |
coenzyme binding |
| molecular_function |
GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| molecular_function |
GO:0050661 |
NADP binding |
| molecular_function |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| None | No IPR available | COILS | Coil | Coil | coord: 365..385 |
| IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II | PRINTS | PR00071 | HMGCOARDTASE | coord: 579..604
score: 74.84
coord: 630..656
score: 71.37
coord: 685..706
score: 73.11
coord: 421..442
score: 67.05
coord: 539..557
score: 75.0
coord: 448..468
score: 85.02 |
| IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II | PFAM | PF00368 | HMG-CoA_red | coord: 385..765
e-value: 1.3E-141
score: 471.8 |
| IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II | PROSITE | PS50065 | HMG_COA_REDUCTASE_4 | coord: 358..765
score: 116.259 |
| IPR004554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | TIGRFAM | TIGR00533 | TIGR00533 | coord: 356..765
e-value: 5.9E-154
score: 510.8 |
| IPR004554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | CDD | cd00643 | HMG-CoA_reductase_classI | coord: 359..765
e-value: 0.0
score: 645.377 |
| IPR009023 | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain | GENE3D | 3.30.70.420 | | coord: 482..585
e-value: 6.6E-50
score: 168.0 |
| IPR009023 | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain | SUPERFAMILY | 55035 | NAD-binding domain of HMG-CoA reductase | coord: 482..598 |
| IPR023074 | Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain | GENE3D | 3.90.770.10 | | coord: 586..769
e-value: 8.9E-59
score: 198.3 |
| IPR023282 | Hydroxymethylglutaryl-CoA reductase, N-terminal | GENE3D | 1.10.3270.10 | | coord: 348..431
e-value: 5.8E-27
score: 93.2 |
| IPR023076 | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site | PROSITE | PS00066 | HMG_COA_REDUCTASE_1 | coord: 541..555 |
| IPR023076 | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site | PROSITE | PS01192 | HMG_COA_REDUCTASE_3 | coord: 750..763 |
| IPR009029 | Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain | SUPERFAMILY | 56542 | Substrate-binding domain of HMG-CoA reductase | coord: 347..479
coord: 596..755 |
Blast
BLAST of TCONS_00019329-protein vs. Swiss-Prot (Human)
Match: HMDH (3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Homo sapiens GN=HMGCR PE=1 SV=1) HSP 1 Score: 509.99 bits (1312), Expect = 7.131e-169 Identity = 239/411 (58.15%), Postives = 313/411 (76.16%), Query Frame = 0
Query: 356 LSNEEILQLCKEKKLALHSLEATLNDHKRAVEIRRSFVTAEIGKEADALDDLPYENYNYEKVYGVCCENVIGYCTVPLGVAGPLLLDNNKFYVPMATTEGCLVASTNRGCSALRASGGVFSYLIGDGMTRGPVVRMTSAREACLVREWIEEQDNFIILSEAFNQSSRFTELLEIKCAMAGKLLFLRFKASTGDAMGMNMVSKGTEHALKYLKIQFPSMEVVSLSGNYCTDKKPSAINWIDGRGKGVICEATIPGEIVRKTLKTNPEALIEVNISKNLIGSALAGSIGGQNAHAANIVAAIFIATGQDPAQTVVSSNCITVMELAGENMTDLYISCTMPSIETGTIGGGTSLPSQKSALKLLGLD-EIRGMPGKNSQQLARVICGTVLAGELSLLSALASNHLVKSHMKLNR 765
LS+ EI+QL K + + LE + H+R V IRR ++ ++ E +L LPY +YNY V G CCENVIGY +P+GVAGPL LD +F VPMATTEGCLVASTNRGC A+ GG S ++ DGMTRGPVVR+ A ++ V+ W+E + F ++ EAF+ +SRF L ++ ++AG+ L++RF++ +GDAMGMNM+SKGTE AL L FP M+++++SGNYCTDKKP+AINWI+GRGK V+CEA IP ++VR+ LKT EA+IEVNI+KNL+GSA+AGSIGG NAHAANIV AI+IA GQD AQ V SSNCIT+ME +G DLYISCTMPSIE GT+GGGT+L Q++ L++LG+ + PG+N++QLAR++CGTV+AGELSL++ALA+ HLVKSHM NR
Sbjct: 462 LSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKL-SEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNR 871
The following BLAST results are available for this feature:
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