TCONS_00011539-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00011539-protein
Unique NameTCONS_00011539-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length694

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00011539-protein ID=TCONS_00011539-protein|Name=TCONS_00011539-protein|organism=Clytia hemisphaerica|type=polypeptide|length=694bp
MMADLDLLGNSKSPLKSPGKTLPKIPKKVKEEPQSPVKSPTKSPTTNGHS
NGSAKKEVKKEEMSDDEDMPLQSVKKESRKRKVKEEDEDFEDSKKKKKKK
DKKKVKKEAKEVKKESPKKRVKKEEVKEEVWRWWEETPHPEGIKWKTLEH
NGPYFPPAYERLPKNVKFYYDGELMELSEGAEEVATFYSKMLEHDYTKKD
IFNNNFFEDWRKEMTDQERKKIKKLEKCNFQEMCDYFKEQSEIRKNKTKE
EKLALKEENAAIAEQYGMCIMDGHKQKVGNFRIEPPGLFRGRGDHPKQGK
LKKRVKAKEVSINIGKAAPVPQPPEGQKWKAVQHDASVTWLACWTENITG
SNKYVMLNAATRIKGEKDWQKYETARKLKGCVHKIRENYKADWKSKEMRI
RQRAVAMYFIDKLALRAGHEKEEGESADTVGCCSLRVEHIKLYSEKDGEE
YVVEFDFLGKDSIRYTNSVPVEKRVYKNLELFKQNKQPGDDLFDRLNTGS
LNKFLGEQMPGLTAKVFRTYNASNTLQQQLDTLTEPDANVTAKFLQYNRA
NRAVAILCNHQRAPPKTFDKQMENLITKLKDKKKQMKTVKKEIKELKKEY
HNQGKSEKVKNMIEKKKKQAERLEEQYFKLEVNMTDKEENKEIALGTSKL
NYLDPRISIAWCKKNDVPIEKIYNKTQREKFQWAIDMTDETFVF
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_006465XLOC_006465Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00011539TCONS_00011539Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001631TopoI
IPR013499TopoI_euk
IPR025834TopoI_C_dom
IPR014727TopoI_cat_a/b-sub_euk
IPR013030TopoI_DNA-bd_mixed-a/b_euk
IPR013500TopoI_cat_euk
IPR008336TopoI_DNA-bd_euk
IPR013034DNA_topo_domain1
IPR014711TopoI_cat_a-hlx-sub_euk
IPR018521TopoI_AS
IPR011010DNA_brk_join_enz
Vocabulary: Molecular Function
TermDefinition
GO:0003677DNA binding
GO:0003917DNA topoisomerase type I activity
Vocabulary: Biological Process
TermDefinition
GO:0006265DNA topological change
Vocabulary: Cellular Component
TermDefinition
GO:0005694chromosome
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006265 DNA topological change
cellular_component GO:0005694 chromosome
molecular_function GO:0003677 DNA binding
molecular_function GO:0003917 DNA topoisomerase type I activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 572..640
NoneNo IPR availableCOILSCoilCoilcoord: 95..115
NoneNo IPR availableCOILSCoilCoilcoord: 238..265
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..121
NoneNo IPR availableCDDcd03488Topoisomer_IB_N_htopoI_likecoord: 144..358
e-value: 1.58368E-122
score: 365.894
NoneNo IPR availableSUPERFAMILY46596Eukaryotic DNA topoisomerase I, dispensable insert domaincoord: 569..641
IPR001631DNA topoisomerase IPRINTSPR00416EUTPISMRASEIcoord: 646..657
score: 72.92
coord: 426..440
score: 71.19
coord: 453..469
score: 64.08
coord: 511..525
score: 77.14
coord: 402..421
score: 66.25
coord: 288..297
score: 69.64
IPR013499DNA topoisomerase I, eukaryotic-typeSMARTSM00435topeucoord: 288..666
e-value: 2.6E-228
score: 774.4
IPR025834Topoisomerase I C-terminal domainPFAMPF14370Topo_C_assoccoord: 625..694
e-value: 2.4E-33
score: 113.8
IPR014727DNA topoisomerase I, catalytic core, alpha/beta subdomainGENE3D1.10.132.10coord: 515..694
e-value: 5.5E-69
score: 231.1
IPR013030DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-typeGENE3D2.170.11.10coord: 240..358
e-value: 5.3E-44
score: 148.8
IPR013500DNA topoisomerase I, catalytic core, eukaryotic-typePFAMPF01028Topoisom_Icoord: 362..592
e-value: 1.9E-98
score: 328.2
IPR013500DNA topoisomerase I, catalytic core, eukaryotic-typeCDDcd00659Topo_IB_Ccoord: 366..566
e-value: 7.50699E-84
score: 264.909
IPR008336DNA topoisomerase I, DNA binding, eukaryotic-typePFAMPF02919Topoisom_I_Ncoord: 143..357
e-value: 8.3E-96
score: 319.5
IPR008336DNA topoisomerase I, DNA binding, eukaryotic-typeSUPERFAMILY56741Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragmentcoord: 129..358
IPR013034DNA topoisomerase I, domain 1GENE3D1.10.10.41coord: 160..239
e-value: 7.1E-31
score: 105.6
IPR014711DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-typeGENE3D3.90.15.10coord: 359..507
e-value: 1.3E-57
score: 193.3
IPR018521DNA topoisomerase I, active sitePROSITEPS00176TOPOISOMERASE_I_EUKcoord: 639..657
IPR011010DNA breaking-rejoining enzyme, catalytic coreSUPERFAMILY56349DNA breaking-rejoining enzymescoord: 641..693
coord: 362..568

Blast
[Close]
BLAST of TCONS_00011539-protein vs. Swiss-Prot (Human)
Match: TOP1 (DNA topoisomerase 1 OS=Homo sapiens GN=TOP1 PE=1 SV=2)

HSP 1 Score: 785.793 bits (2028), Expect = 0.000e+0
Identity = 381/556 (68.53%), Postives = 448/556 (80.58%), Query Frame = 0 
Query:  139 HPEGIKWKTLEHNGPYFPPAYERLPKNVKFYYDGELMELSEGAEEVATFYSKMLEHDYTKKDIFNNNFFEDWRKEMTDQERKKIKKLEKCNFQEMCDYFKEQSEIRKNKTKEEKLALKEENAAIAEQYGMCIMDGHKQKVGNFRIEPPGLFRGRGDHPKQGKLKKRVKAKEVSINIGKAAPVPQPPEGQKWKAVQHDASVTWLACWTENITGSNKYVMLNAATRIKGEKDWQKYETARKLKGCVHKIRENYKADWKSKEMRIRQRAVAMYFIDKLALRAGHEKEEGESADTVGCCSLRVEHIKLYSEKDGEEYVVEFDFLGKDSIRYTNSVPVEKRVYKNLELFKQNKQPGDDLFDRLNTGSLNKFLGEQMPGLTAKVFRTYNASNTLQQQLDTLTEPDANVTAKFLQYNRANRAVAILCNHQRAPPKTFDKQMENLITKLKDKKKQMKTVKKEIKELKKEYHNQGKSEKVKNMIEKKKKQAERLEEQYFKLEVNMTDKEENKEIALGTSKLNYLDPRISIAWCKKNDVPIEKIYNKTQREKFQWAIDMTDETFVF 694
            +PEGIKWK LEH GP F P YE LP+NVKFYYDG++M+LS  AEEVATF++KML+H+YT K+IF  NFF+DWRKEMT++E+  I  L KC+F +M  YFK Q+E RK  +KEEKL +KEEN  + ++YG CIMD HK+++ NF+IEPPGLFRGRG+HPK G LK+R+  +++ IN  K A VP PP G KWK V+HD  VTWL  WTENI GS KY+MLN ++RIKGEKDWQKYETAR+LK CV KIR  Y+ DWKSKEM++RQRAVA+YFIDKLALRAG+EKEEGE+ADTVGCCSLRVEHI L+ E DG+EYVVEFDFLGKDSIRY N VPVEKRV+KNL+LF +NKQP DDLFDRLNTG LNK L + M GLTAKVFRTYNAS TLQQQL  LT PD N+ AK L YNRANRAVAILCNHQRAPPKTF+K M NL TK+  KK+Q+   ++++K  K +     K  K K ++E KKK  +RLEEQ  KLEV  TD+EENK+IALGTSKLNYLDPRI++AWCKK  VPIEKIYNKTQREKF WAIDM DE + F
Sbjct:  211 YPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVM-KDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 765
The following BLAST results are available for this feature:
BLAST of TCONS_00011539-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
TOP10.000e+068.53DNA topoisomerase 1 OS=Homo sapiens GN=TOP1 PE=1 S... [more]
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