TCONS_00002349-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00002349-protein
Unique Name	TCONS_00002349-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	632

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00002349-protein ID=TCONS_00002349-protein|Name=TCONS_00002349-protein|organism=Clytia hemisphaerica|type=polypeptide|length=632bp
MGIKILEKFSFWNNKDGFTPIDVVCLLPNGICHTFPSLRADTPLSQIKEK
LWQEATRFAMASMLRSRNQYVFAVVSRNGGTEELINESLSLFDIKPVRPY
LKVVERQGDEQLKQLNSKINLLIGRPASTSAKDEQVNDLRTRCMLFCNRI
SEQRSRASWERRAIYTFPPDFEEDTDLPIALQRTLDTLDGFIAISIHYKY
NHVLHKQTHRVSHKLHPRDLIEKGLQKFNINNRTNEKPDDYVLKELGSEN
YFLGHVENETEIYRERPLIQYKYIRECLLWDRQICLKIVERSQLDVGKIE
RGSNEVPPPLPNKERESNRLSLWDITPSTMLRLKVHCALNIMADANMWKE
VQVGIFHGGEEVCESQITSRQRGIHPVWNEYLEFKLPVSNIPRMARVCVC
IVGWKKREERKKKEAVPLAWANISVFDYKAIMKQSTHRVNCKQHTARSIK
GDHSFFNPLGAVSTDAGSESKGLCIVIDFMKFAHTVVYPTEHYIRDCAMH
SPERRREVTVFNNRTWDSWRPQIEELIGHDALYDLYDDDKELLWEWREKC
LELYPESLPKILKCVKWDNHEDVKEIHFLLNKWNLSRMEVEIALELLDYK
FPDIEVRRLAVQVLDSLSDSQLEMYFLHLVQV

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_001239	XLOC_001239	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00002349	TCONS_00002349	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR000341	PI3K_Ras-bd_dom
IPR002420	PI3K_C2_dom
IPR001263	PInositide-3_kin_accessory_dom
IPR003113	PI3K_adapt-bd_dom
IPR000008	C2_dom
IPR016024	ARM-type_fold
IPR029071	Ubiquitin-rel_dom

Vocabulary: **Molecular Function**
Term	Definition
GO:0005488	binding

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
molecular_function	GO:0005488	binding

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	SMART	SM00144	pi3k_ras_2	coord: 177..293 e-value: 5.6E-5 score: 32.5
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	PFAM	PF00794	PI3K_rbd	coord: 189..292 e-value: 4.3E-8 score: 33.2
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	PROSITE	PS51546	PI3K_RBD	coord: 189..290 score: 20.181
IPR002420	Phosphatidylinositol 3-kinase, C2 domain	SMART	SM00142	pi3k_hr3_6	coord: 317..421 e-value: 9.4E-5 score: 31.8
IPR002420	Phosphatidylinositol 3-kinase, C2 domain	PFAM	PF00792	PI3K_C2	coord: 351..441 e-value: 6.8E-16 score: 58.5
IPR002420	Phosphatidylinositol 3-kinase, C2 domain	PROSITE	PS51547	PI3K_C2	coord: 327..489 score: 23.532
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	SMART	SM00145	pi3k_hr2_4	coord: 505..632 e-value: 3.1E-5 score: 12.9
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	PFAM	PF00613	PI3Ka	coord: 520..632 e-value: 3.4E-23 score: 81.9
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	PROSITE	PS51545	PIK_HELICAL	coord: 509..632 score: 18.766
IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain	SMART	SM00143	pi3k_nt_2	coord: 32..110 e-value: 1.1E-4 score: 30.8
IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain	PFAM	PF02192	PI3K_p85B	coord: 40..109 e-value: 1.0E-18 score: 66.7
IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain	PROSITE	PS51544	PI3K_ABD	coord: 17..107 score: 22.281
None	No IPR available	GENE3D	3.10.20.90		coord: 20..107 e-value: 3.6E-24 score: 84.0
None	No IPR available	GENE3D	3.10.20.90		coord: 108..321 e-value: 1.5E-35 score: 122.1
None	No IPR available	GENE3D	1.25.40.70		coord: 498..632 e-value: 1.4E-29 score: 102.5
IPR000008	C2 domain	GENE3D	2.60.40.150		coord: 328..489 e-value: 1.5E-28 score: 98.8
IPR000008	C2 domain	SUPERFAMILY	49562	C2 domain (Calcium/lipid-binding domain, CaLB)	coord: 320..446
IPR016024	Armadillo-type fold	SUPERFAMILY	48371	ARM repeat	coord: 518..632
IPR029071	Ubiquitin-related domain	SUPERFAMILY	54236	Ubiquitin-like	coord: 109..295

Blast

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BLAST of TCONS_00002349-protein vs. Swiss-Prot (Human)
Match: PK3CA (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Homo sapiens GN=PIK3CA PE=1 SV=2)

HSP 1 Score: 266.544 bits (680), Expect = 1.965e-77
Identity = 190/642 (29.60%), Postives = 315/642 (49.07%), Query Frame = 0

Query:   21 IDVVCLLPNGICHTFPSLRADTPLSQIKEKLWQEATRFAMASMLRSRNQYVFAVVSRNGGTEELINESLSLFDIKPVRPYLKVVERQGDEQLKQLNSKINLLIGRPAS--TSAKDEQVNDLRTRCMLFCNRISEQRSRASWERRAIYTFPPDFEEDTDLPIALQRTLDTLDGFIAISIHYKYNHVLHKQTHRVSHKLHPRDLIEKGLQKFNINNRTN---------EKPDDYVLKELGSENYFLGHVENETEIYRERPLIQYKYIRECLLWDRQICLKIVERSQL------DVGKIERGSNEVPPPLPNKERESNRLSLWDITPSTMLRLKVHCALNIMADANMWKEVQV--GIFHGGEEVCESQITSRQRGIHPVWNEYLEFKLPVSNIPRMARVCVCIVGWKKREERKKKEAVPLAWANISVFDYKAIMKQSTHRVNCKQHTARSIKGDHSFFNPLGAVSTDAGSESKGLCIVIDFMKFAHTVVYPTEHYIRDCAMHSPERRREVT----------VFNNRTWDSWRPQIEELIGHDALYDLYDDDKELLWEWREKCLELYPESLPKILKCVKWDNHEDVKEIHFLLNKWNLSRMEVEIALELLDYKFPDIEVRRLAVQVLDS-LSDSQLEMYFLHLVQV 632
            I V CLLPNG+  T   LR  T L  IK +L++EA ++ +  +L+  + Y+F  V++    EE  +E+  L D++  +P+LKV+E  G+ + K LN +I   IG P       KD +V D R   +  C    + R   S   RA+Y +PP+ E   +LP  +   LD     + I +    N+   K T +++H   P  +I + ++K   +   +         E    Y+LK  G + YFL           + PL QYKYIR C++  R   L ++ +  L      D   +   S  +    P    E++  SLW I  ++ LR+K+ CA  +  +     ++ V  GI+HGGE +C++  T R    +P WNE+L + + + ++PR AR+C+ I   K R+   K+E  PLAW NI++FDY   +      +N          G     NP+G   ++   E+   C+ ++F  F+  V +P    I + A  S  R    +            +N   ++ + Q++ +   D L ++ + +K+ LW  R  C+ + PE LPK+L  VKW++ ++V +++ L+  W    ++ E A+ELLD  +PD  VR  AV+ L+  L+D +L  Y + LVQV
Sbjct:   20 ILVECLLPNGMIVTLECLREAT-LITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFL----------EKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVI--NSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKG-AKEEHCPLAWGNINLFDYTDTLVSGKMALN----LWPVPHGLEDLLNPIGVTGSNPNKETP--CLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTI-PEILPKLLLSVKWNSRDEVAQMYCLVKDW--PPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQV 638

The following BLAST results are available for this feature:

BLAST of TCONS_00002349-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00002349-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
PK3CA	1.965e-77	29.60	Phosphatidylinositol 4,5-bisphosphate 3-kinase cat...	[more]

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TCONS_00002349-protein (polypeptide) - C. hemisphaerica